GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.6
PAE mean: 24.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | A | 685 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | L | 899 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | L | 899 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | ICL3 | L | 686 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL3 | L | 686 | - | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | L | 896 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | I | 591 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | H8 | F | 762 | 8x57 | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | C-term | I | 898 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | I | 898 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | ICL2 | M | 587 | - | G.S1 | E | 39 | G.S1.01 |
Hydrophobic | C-term | P | 897 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Ionic | H8 | R | 758 | 8x53 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | H8 | R | 758 | 8x53 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | H8 | R | 758 | 8x53 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | H8 | R | 758 | 8x53 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | C-term | L | 896 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | C-term | L | 892 | - | G.H3 | A | 253 | G.H3.07 |
Van-der-waals | C-term | L | 892 | - | G.H3 | A | 253 | G.H3.07 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | I | 581 | 3x57 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL1 | K | 510 | 12x48 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL1 | K | 510 | 12x48 | G.H5 | V | 359 | G.H5.26 |
Polar | C-term | N | 883 | - | G.s4h3 | N | 244 | G.s4h3.13 |
Van-der-waals | C-term | N | 883 | - | G.s4h3 | N | 244 | G.s4h3.13 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL2 | K | 590 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | K | 590 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | K | 590 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL1 | K | 513 | 12x51 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | I | 888 | - | G.H3 | E | 249 | G.H3.03 |
Hydrophobic | C-term | L | 896 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | L | 896 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | Q | 895 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | Q | 895 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | L | 349 | G.H5.16 |
Polar | C-term | L | 899 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 899 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 899 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Polar | C-term | Q | 895 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | Q | 895 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | Q | 895 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | ICL3 | I | 683 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL3 | I | 683 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | L | 892 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | L | 892 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | C-term | I | 888 | - | G.H3 | E | 250 | G.H3.04 |
Van-der-waals | C-term | I | 888 | - | G.H3 | E | 250 | G.H3.04 |
Hydrophobic | C-term | I | 882 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Van-der-waals | C-term | I | 882 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Hydrophobic | TM2 | S | 516 | 2x35 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | S | 516 | 2x35 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL2 | K | 588 | - | G.HN | K | 33 | G.HN.51 |
Van-der-waals | ICL2 | K | 588 | - | G.HN | K | 33 | G.HN.51 |
Hydrophobic | H8 | F | 762 | 8x57 | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | C-term | L | 896 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | L | 896 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | TM4 | K | 593 | 4x28 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | R | 891 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | R | 891 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | N | 883 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Van-der-waals | C-term | N | 883 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | C-term | L | 896 | - | G.H3 | I | 258 | G.H3.12 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | L | 351 | G.H5.18 |
Polar | C-term | Q | 889 | - | G.H3 | R | 256 | G.H3.10 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | K | 589 | - | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | M | 587 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | M | 587 | - | G.hns1 | R | 37 | G.hns1.02 |
Ionic | C-term | R | 891 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Polar | C-term | R | 891 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Van-der-waals | C-term | R | 891 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Hydrophobic | ICL2 | M | 587 | - | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | M | 587 | - | G.hns1 | R | 38 | G.hns1.03 |
Polar | C-term | L | 896 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 896 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 896 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL3 | A | 685 | - | G.H5 | L | 353 | G.H5.20 |
Polar | ICL2 | K | 588 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | K | 588 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | K | 588 | - | G.hns1 | R | 37 | G.hns1.02 |
Ionic | ICL2 | K | 589 | - | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | K | 589 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | K | 589 | - | G.H5 | E | 355 | G.H5.22 |
Polar | TM4 | D | 594 | 4x29 | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | Q | 895 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | Q | 895 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | Q | 895 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | ICL2 | K | 588 | - | G.HN | R | 34 | G.HN.52 |
Van-der-waals | ICL2 | K | 588 | - | G.HN | R | 34 | G.HN.52 |
Hydrophobic | C-term | L | 892 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | L | 892 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | ICL2 | M | 587 | - | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | M | 587 | - | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL3 | I | 683 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL3 | I | 683 | - | G.H5 | L | 353 | G.H5.20 |
Polar | TM3 | R | 577 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 577 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 577 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | I | 898 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | I | 898 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | TM3 | R | 577 | 3x53 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | R | 577 | 3x53 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | F | 582 | 3x58 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | F | 582 | 3x58 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | V | 359 | G.H5.26 |
Ionic | ICL1 | K | 510 | 12x48 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | ICL1 | K | 510 | 12x48 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | ICL1 | K | 510 | 12x48 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | ICL2 | M | 587 | - | G.S3 | V | 199 | G.S3.01 |
Van-der-waals | ICL2 | M | 587 | - | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | I | 591 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | I | 888 | - | G.H3 | A | 253 | G.H3.07 |
Van-der-waals | C-term | I | 888 | - | G.H3 | A | 253 | G.H3.07 |
Hydrophobic | H8 | R | 758 | 8x53 | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | ICL2 | I | 592 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | I | 592 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | I | 592 | - | G.H5 | Y | 356 | G.H5.23 |
Polar | H8 | R | 758 | 8x53 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | H8 | R | 758 | 8x53 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | H8 | R | 758 | 8x53 | G.h4s6 | S | 320 | G.h4s6.11 |
Polar | C-term | N | 883 | - | G.s4h3 | N | 246 | G.s4h3.15 |
Van-der-waals | C-term | N | 883 | - | G.s4h3 | N | 246 | G.s4h3.15 |
Hydrophobic | H8 | F | 760 | 8x55 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL3 | L | 686 | - | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | P | 897 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | ICL1 | K | 513 | 12x51 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL1 | K | 513 | 12x51 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | V | 585 | - | G.H5 | K | 345 | G.H5.12 |