GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 73.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 21.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | A | 685 | - | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | H8 | F | 760 | 8x55 | G.H5 | K | 341 | G.H5.17 |
Polar | C-term | H | 900 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | H | 900 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | ICL2 | M | 587 | - | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | M | 587 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | C-term | R | 799 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Van-der-waals | C-term | R | 799 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Polar | ICL2 | K | 588 | - | G.HN | A | 23 | G.HN.51 |
Hydrophobic | ICL2 | K | 588 | - | G.HN | A | 23 | G.HN.51 |
Van-der-waals | ICL2 | K | 588 | - | G.HN | A | 23 | G.HN.51 |
Hydrophobic | C-term | L | 899 | - | G.H2 | I | 208 | G.H2.08 |
Polar | ICL2 | I | 592 | - | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | I | 592 | - | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | ICL2 | I | 592 | - | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | C-term | I | 898 | - | G.H2 | W | 207 | G.H2.07 |
Van-der-waals | C-term | I | 898 | - | G.H2 | W | 207 | G.H2.07 |
Polar | C-term | L | 899 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | C-term | L | 899 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | C-term | L | 899 | - | G.H3 | H | 252 | G.H3.15 |
Polar | C-term | Q | 895 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | C-term | Q | 895 | - | G.H3 | H | 244 | G.H3.07 |
Van-der-waals | C-term | Q | 895 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | L | 896 | - | G.H3 | L | 245 | G.H3.08 |
Van-der-waals | C-term | L | 896 | - | G.H3 | L | 245 | G.H3.08 |
Hydrophobic | ICL3 | L | 686 | - | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | H8 | F | 760 | 8x55 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | H8 | F | 760 | 8x55 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | ICL2 | M | 587 | - | G.h2s4 | T | 215 | G.h2s4.05 |
Ionic | ICL2 | K | 589 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | ICL2 | K | 589 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | M | 587 | - | G.hns1 | R | 28 | G.hns1.03 |
Polar | H8 | F | 760 | 8x55 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | C-term | Q | 764 | - | G.H5 | K | 329 | G.H5.05 |
Hydrophobic | C-term | Q | 764 | - | G.H5 | K | 329 | G.H5.05 |
Van-der-waals | C-term | Q | 764 | - | G.H5 | K | 329 | G.H5.05 |
Hydrophobic | C-term | R | 891 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | TM4 | D | 594 | 4x29 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | K | 586 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | C-term | T | 803 | - | G.H3 | N | 251 | G.H3.14 |
Hydrophobic | ICL3 | I | 683 | - | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | ICL3 | I | 683 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | H8 | R | 759 | 8x54 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | C-term | Q | 817 | - | G.H2 | K | 205 | G.H2.05 |
Van-der-waals | C-term | Q | 817 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | C-term | H | 900 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | C-term | L | 899 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Van-der-waals | C-term | L | 899 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | C-term | P | 897 | - | G.H2 | K | 205 | G.H2.05 |
Van-der-waals | C-term | P | 897 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | ICL2 | M | 587 | - | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | M | 587 | - | G.hns1 | A | 27 | G.hns1.02 |
Polar | C-term | L | 899 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | ICL1 | M | 514 | 12x52 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | ICL1 | M | 514 | 12x52 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | C-term | I | 898 | - | G.H2 | K | 205 | G.H2.05 |
Van-der-waals | C-term | I | 898 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | C-term | I | 898 | - | G.H2 | K | 206 | G.H2.06 |
Van-der-waals | C-term | I | 898 | - | G.H2 | K | 206 | G.H2.06 |
Hydrophobic | ICL2 | M | 587 | - | G.S1 | T | 29 | G.S1.01 |
Van-der-waals | ICL2 | M | 587 | - | G.S1 | T | 29 | G.S1.01 |
Hydrophobic | ICL2 | K | 588 | - | G.HN | E | 24 | G.HN.52 |
Van-der-waals | ICL2 | K | 588 | - | G.HN | E | 24 | G.HN.52 |
Hydrophobic | C-term | A | 902 | - | G.H2 | I | 208 | G.H2.08 |
Van-der-waals | C-term | A | 902 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | C-term | F | 934 | - | G.HN | A | 7 | G.HN.31 |
Hydrophobic | C-term | H | 929 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | C-term | H | 929 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | C-term | K | 807 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | C-term | L | 894 | - | G.H2 | R | 201 | G.H2.01 |
Polar | C-term | H | 796 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Hydrophobic | C-term | H | 796 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Van-der-waals | C-term | H | 796 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Hydrophobic | TM3 | R | 577 | 3x53 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | R | 577 | 3x53 | G.H5 | L | 349 | G.H5.25 |
Ionic | ICL2 | K | 589 | - | G.H5 | E | 342 | G.H5.18 |
Polar | ICL2 | K | 589 | - | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | E | 342 | G.H5.18 |
Van-der-waals | ICL2 | K | 589 | - | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM3 | I | 581 | 3x57 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | I | 581 | 3x57 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | TM4 | K | 593 | 4x28 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM4 | K | 593 | 4x28 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | K | 586 | - | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | K | 586 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | C-term | I | 898 | - | G.H2 | R | 204 | G.H2.04 |
Van-der-waals | C-term | I | 898 | - | G.H2 | R | 204 | G.H2.04 |
Hydrophobic | C-term | I | 898 | - | G.H2 | I | 208 | G.H2.08 |
Van-der-waals | C-term | I | 898 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | ICL3 | A | 685 | - | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | ICL3 | A | 685 | - | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | C-term | I | 898 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Van-der-waals | C-term | I | 898 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Polar | C-term | A | 902 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | C-term | A | 902 | - | G.H3 | Y | 254 | G.H3.17 |
Van-der-waals | C-term | A | 902 | - | G.H3 | Y | 254 | G.H3.17 |
Van-der-waals | C-term | L | 899 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | C-term | L | 896 | - | G.H2 | W | 207 | G.H2.07 |
Polar | H8 | N | 757 | 8x52 | G.h4s6 | R | 310 | G.h4s6.08 |
Hydrophobic | C-term | I | 882 | - | G.H3 | H | 240 | G.H3.03 |
Van-der-waals | C-term | I | 882 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | ICL2 | M | 587 | - | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | M | 587 | - | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | TM2 | S | 516 | 2x35 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM2 | S | 516 | 2x35 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | M | 800 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Van-der-waals | C-term | M | 800 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Hydrophobic | H8 | N | 757 | 8x52 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | N | 757 | 8x52 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL2 | I | 591 | - | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | ICL2 | I | 591 | - | G.H5 | D | 346 | G.H5.22 |
Polar | ICL2 | K | 588 | - | G.HN | K | 20 | G.HN.48 |
Hydrophobic | C-term | K | 807 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | K | 807 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | C-term | H | 901 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | ICL2 | K | 589 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | K | 589 | - | G.H5 | N | 343 | G.H5.19 |
Polar | C-term | Y | 903 | - | G.H3 | Y | 254 | G.H3.17 |
Aromatic | C-term | Y | 903 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | C-term | Y | 903 | - | G.H3 | Y | 254 | G.H3.17 |
Van-der-waals | C-term | Y | 903 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | ICL2 | K | 588 | - | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | K | 588 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | C-term | Y | 903 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | Y | 903 | - | G.H3 | R | 253 | G.H3.16 |
Ionic | C-term | R | 890 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Polar | C-term | R | 890 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Van-der-waals | C-term | R | 890 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Hydrophobic | ICL3 | I | 683 | - | G.H5 | L | 344 | G.H5.20 |
Polar | TM4 | D | 594 | 4x29 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | F | 582 | 3x58 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | TM3 | F | 582 | 3x58 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | ICL2 | V | 585 | - | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | C-term | R | 891 | - | G.s4h3 | V | 236 | G.s4h3.14 |
Hydrophobic | C-term | L | 899 | - | G.H3 | F | 255 | G.H3.18 |
Hydrophobic | C-term | L | 896 | - | G.H2 | R | 204 | G.H2.04 |
Van-der-waals | C-term | L | 896 | - | G.H2 | R | 204 | G.H2.04 |
Hydrophobic | H8 | F | 760 | 8x55 | G.H5 | F | 350 | G.H5.26 |
Polar | H8 | N | 757 | 8x52 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | H8 | N | 757 | 8x52 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | C-term | T | 803 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Van-der-waals | C-term | T | 803 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Ionic | C-term | E | 811 | - | G.H3 | R | 253 | G.H3.16 |
Polar | C-term | E | 811 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | E | 811 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | ICL2 | V | 585 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | ICL2 | M | 587 | - | G.S1 | V | 30 | G.S1.02 |
Van-der-waals | ICL2 | M | 587 | - | G.S1 | V | 30 | G.S1.02 |