G13 -
GAL1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | R | 133 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | F | 110 | 3x27 | G.HN | L | 5 | G.HN.05 |
Van-der-waals | TM3 | F | 110 | 3x27 | G.HN | L | 5 | G.HN.05 |
Polar | TM4 | V | 170 | 4x61 | G.HN | A | 2 | G.HN.02 |
Hydrophobic | TM4 | V | 170 | 4x61 | G.HN | A | 2 | G.HN.02 |
Van-der-waals | TM4 | V | 170 | 4x61 | G.HN | A | 2 | G.HN.02 |
Polar | TM6 | S | 241 | 6x29 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM6 | S | 241 | 6x29 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM6 | S | 241 | 6x29 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM6 | V | 249 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | V | 249 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Polar | TM5 | K | 230 | 5x68 | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | TM5 | K | 230 | 5x68 | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | TM5 | K | 230 | 5x68 | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | TM3 | K | 109 | 3x26 | G.HN | A | 2 | G.HN.02 |
Hydrophobic | TM3 | K | 109 | 3x26 | G.HN | A | 2 | G.HN.02 |
Van-der-waals | TM3 | K | 109 | 3x26 | G.HN | A | 2 | G.HN.02 |
Polar | ICL2 | S | 140 | 34x50 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | S | 140 | 34x50 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | S | 140 | 34x50 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM6 | T | 245 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | T | 245 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | F | 106 | 3x23 | G.HN | L | 5 | G.HN.05 |
Hydrophobic | TM3 | F | 106 | 3x23 | G.HN | D | 3 | G.HN.03 |
Van-der-waals | TM6 | T | 245 | 6x33 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM6 | T | 248 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Polar | TM2 | T | 69 | 2x38 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM3 | F | 110 | 3x27 | G.HN | D | 3 | G.HN.03 |
Hydrophobic | ICL2 | S | 144 | 34x54 | G.HN | Y | 44 | G.HN.53 |
Polar | H8 | K | 312 | 8x52 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | H8 | K | 312 | 8x52 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | H8 | K | 312 | 8x52 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | TM3 | C | 108 | 3x25 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | C | 108 | 3x25 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | ECL1 | W | 101 | 23x50 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | ECL1 | W | 101 | 23x50 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | ICL3 | M | 234 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | M | 234 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL2 | S | 144 | 34x54 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | S | 144 | 34x54 | G.HN | T | 43 | G.HN.52 |
Polar | TM6 | K | 237 | 6x25 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | TM6 | K | 237 | 6x25 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | TM6 | K | 237 | 6x25 | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | TM6 | K | 242 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | K | 242 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | K | 242 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ECL2 | C | 187 | 45x50 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | ECL2 | C | 187 | 45x50 | G.HN | M | 1 | G.HN.01 |
Polar | ICL2 | S | 140 | 34x50 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | S | 140 | 34x50 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | S | 140 | 34x50 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | TM5 | L | 227 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 227 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL2 | S | 144 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Polar | ICL1 | P | 66 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL1 | P | 66 | - | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ICL1 | P | 66 | - | G.HN | K | 42 | G.HN.51 |
Polar | TM6 | S | 238 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | S | 238 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | S | 238 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM3 | H | 112 | 3x29 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | H | 112 | 3x29 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 137 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM4 | A | 171 | 4x62 | G.HN | A | 2 | G.HN.02 |
Van-der-waals | TM4 | A | 171 | 4x62 | G.HN | A | 2 | G.HN.02 |
Polar | ICL2 | S | 140 | 34x50 | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ICL2 | S | 143 | 34x53 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | S | 143 | 34x53 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | S | 143 | 34x53 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM5 | K | 230 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | K | 230 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Aromatic | TM3 | Y | 113 | 3x30 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM3 | Y | 113 | 3x30 | G.HN | F | 4 | G.HN.04 |
Van-der-waals | TM3 | Y | 113 | 3x30 | G.HN | F | 4 | G.HN.04 |
Polar | H8 | N | 309 | 8x49 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM3 | Y | 113 | 3x30 | G.HN | A | 2 | G.HN.02 |
Van-der-waals | TM3 | Y | 113 | 3x30 | G.HN | A | 2 | G.HN.02 |
Polar | TM6 | K | 237 | 6x25 | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM6 | K | 237 | 6x25 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | TM6 | K | 237 | 6x25 | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM5 | V | 223 | 5x61 | G.H5 | M | 375 | G.H5.24 |
Polar | H8 | E | 308 | 8x48 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM4 | V | 148 | 4x38 | G.HN | S | 39 | G.HN.48 |
Van-der-waals | TM4 | V | 148 | 4x38 | G.HN | S | 39 | G.HN.48 |
Polar | ICL2 | R | 141 | 34x51 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 141 | 34x51 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 141 | 34x51 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL3 | M | 234 | - | G.H5 | D | 361 | G.H5.10 |
Polar | ICL2 | R | 147 | 34x57 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | R | 147 | 34x57 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | R | 147 | 34x57 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL1 | K | 65 | - | G.HN | K | 42 | G.HN.51 |
Polar | TM2 | T | 70 | 2x39 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM5 | L | 231 | 5x69 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM4 | A | 171 | 4x62 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | TM6 | T | 248 | 6x36 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM7 | L | 306 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | I | 111 | 3x28 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM6 | K | 244 | 6x32 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM6 | K | 244 | 6x32 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | H8 | N | 309 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | N | 309 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM3 | R | 133 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Ionic | ICL2 | R | 141 | 34x51 | G.S2 | E | 212 | G.S2.07 |
Polar | ICL2 | R | 141 | 34x51 | G.S2 | E | 212 | G.S2.07 |
Hydrophobic | ICL2 | R | 141 | 34x51 | G.S2 | E | 212 | G.S2.07 |
Van-der-waals | ICL2 | R | 141 | 34x51 | G.S2 | E | 212 | G.S2.07 |
Hydrophobic | ICL2 | S | 143 | 34x53 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | S | 143 | 34x53 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM2 | T | 70 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | T | 70 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Polar | H8 | K | 312 | 8x52 | G.h3s5 | S | 282 | G.h3s5.01 |
Polar | TM4 | V | 170 | 4x61 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM4 | V | 170 | 4x61 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM4 | V | 170 | 4x61 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM5 | L | 231 | 5x69 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | L | 231 | 5x69 | G.H5 | D | 364 | G.H5.13 |
Ionic | TM3 | K | 109 | 3x26 | G.HN | D | 3 | G.HN.03 |
Polar | TM3 | K | 109 | 3x26 | G.HN | D | 3 | G.HN.03 |
Hydrophobic | TM3 | K | 109 | 3x26 | G.HN | D | 3 | G.HN.03 |
Van-der-waals | TM3 | K | 109 | 3x26 | G.HN | D | 3 | G.HN.03 |
Hydrophobic | TM2 | I | 74 | 2x43 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | I | 74 | 2x43 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | S | 140 | 34x50 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | S | 140 | 34x50 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | S | 140 | 34x50 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM4 | Q | 174 | 4x65 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM4 | Q | 174 | 4x65 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM4 | Q | 174 | 4x65 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM4 | I | 164 | 4x54 | G.HN | F | 4 | G.HN.04 |
Polar | TM2 | S | 68 | 2x37 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM2 | S | 68 | 2x37 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM2 | S | 68 | 2x37 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | H8 | S | 307 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM3 | A | 136 | 3x53 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | A | 136 | 3x53 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | A | 136 | 3x53 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM6 | S | 241 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | S | 241 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | S | 241 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Polar | TM3 | H | 139 | 3x56 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | H | 139 | 3x56 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | H | 139 | 3x56 | G.hns1 | R | 47 | G.hns1.03 |
Polar | H8 | S | 307 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | S | 307 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | S | 307 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM4 | A | 171 | 4x62 | G.HN | M | 1 | G.HN.01 |
Polar | H8 | E | 308 | 8x48 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | H8 | E | 308 | 8x48 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | H8 | E | 308 | 8x48 | G.h3s5 | N | 283 | G.h3s5.02 |
Polar | ICL2 | R | 141 | 34x51 | G.hns1 | R | 47 | G.hns1.03 |
Polar | H8 | E | 308 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | V | 135 | 3x52 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | V | 135 | 3x52 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL3 | M | 234 | - | G.H5 | T | 365 | G.H5.14 |
Van-der-waals | ICL3 | M | 234 | - | G.H5 | T | 365 | G.H5.14 |
Hydrophobic | TM3 | K | 109 | 3x26 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | K | 109 | 3x26 | G.HN | M | 1 | G.HN.01 |