G15 -
GAL1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | A | 136 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 136 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM2 | S | 68 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM2 | S | 68 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | S | 68 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | I | 137 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | S | 307 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | S | 307 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | S | 307 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Polar | TM6 | S | 241 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Polar | TM6 | T | 245 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | T | 245 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | T | 245 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | V | 223 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | N | 309 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Polar | C-term | T | 347 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | T | 347 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM5 | L | 227 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Polar | C-term | T | 347 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | V | 349 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | V | 349 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | ICL2 | S | 140 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | T | 344 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | T | 344 | - | G.S2 | I | 192 | G.S2.01 |
Polar | TM3 | R | 133 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | P | 342 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | ICL3 | M | 234 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | M | 234 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | T | 344 | - | G.S2 | E | 194 | G.S2.03 |
Polar | C-term | C | 346 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | C | 346 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | C | 346 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM4 | V | 148 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | V | 148 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM5 | H | 226 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | K | 230 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | K | 230 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | N | 345 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | N | 345 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | N | 345 | - | G.S2 | N | 193 | G.S2.02 |
Polar | ICL2 | R | 141 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | R | 141 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | R | 141 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | R | 141 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | R | 141 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Ionic | H8 | E | 308 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | H8 | E | 308 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | H8 | E | 308 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | H8 | E | 308 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | TM6 | T | 248 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | P | 342 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | P | 342 | - | G.H2 | H | 221 | G.H2.09 |
Polar | ICL2 | R | 141 | 34x51 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | ICL2 | R | 141 | 34x51 | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 141 | 34x51 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | TM6 | V | 249 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | T | 347 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | T | 347 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | H8 | E | 308 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | E | 308 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | A | 136 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | A | 136 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM6 | K | 244 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | P | 342 | - | G.S2 | I | 192 | G.S2.01 |
Polar | ICL2 | S | 145 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM5 | K | 230 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Polar | C-term | V | 349 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | V | 349 | - | G.S2 | C | 196 | G.S2.05 |
Polar | ICL2 | S | 144 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Ionic | ICL2 | R | 147 | 34x57 | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | R | 147 | 34x57 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | R | 147 | 34x57 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL2 | R | 147 | 34x57 | G.H5 | E | 370 | G.H5.22 |
Polar | TM6 | K | 244 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 244 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 244 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | V | 349 | - | G.S2 | F | 197 | G.S2.06 |
Polar | TM2 | T | 70 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | T | 70 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | R | 141 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | V | 349 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | V | 349 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | C-term | N | 345 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | N | 345 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | P | 341 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | ICL2 | R | 147 | 34x57 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | R | 147 | 34x57 | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | S | 140 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | S | 140 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | S | 140 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM5 | L | 227 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | L | 227 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | N | 345 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | N | 345 | - | G.S2 | E | 194 | G.S2.03 |
Polar | ICL2 | S | 144 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | S | 144 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | S | 144 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Ionic | H8 | E | 308 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | H8 | E | 308 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | H8 | E | 308 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | H8 | E | 308 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL2 | S | 145 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | TM6 | S | 241 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | S | 241 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL2 | R | 142 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | ICL2 | S | 143 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | S | 143 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | S | 143 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | H | 348 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | H | 348 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | L | 368 | G.H5.20 |