Gs - GAL1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 227 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL3 M 234 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 M 234 - G.H5 D 381 G.H5.13
Hydrophobic TM6 V 249 6x37 G.H5 L 393 G.H5.25
Polar TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Polar TM3 I 137 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 230 5x68 G.H5 R 380 G.H5.12
Van-der-waals TM5 K 230 5x68 G.H5 R 380 G.H5.12
Polar H8 F 310 8x50 G.H5 E 392 G.H5.24
Polar H8 S 307 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 307 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 307 8x47 G.H5 E 392 G.H5.24
Polar TM6 K 237 6x25 G.h4s6 G 353 G.h4s6.09
Van-der-waals TM6 K 237 6x25 G.h4s6 G 353 G.h4s6.09
Hydrophobic TM2 T 70 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 70 2x39 G.H5 Y 391 G.H5.23
Polar TM3 D 132 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 132 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 132 3x49 G.H5 Y 391 G.H5.23
Polar H8 E 308 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 E 308 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 E 308 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 A 136 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 136 3x53 G.H5 Y 391 G.H5.23
Polar TM6 T 245 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 245 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 245 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 137 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 R 141 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 141 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL3 M 234 - G.S6 Y 360 G.S6.02
Hydrophobic TM7 L 306 7x56 G.H5 E 392 G.H5.24
Polar H8 N 309 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 N 309 8x49 G.H5 R 389 G.H5.21
Hydrophobic TM6 K 237 6x25 G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL2 R 141 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 R 141 34x51 G.H5 F 376 G.H5.08
Ionic H8 E 308 8x48 G.h4s6 R 356 G.h4s6.12
Polar TM3 A 136 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 136 3x53 G.H5 H 387 G.H5.19
Polar H8 N 309 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 N 309 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 N 309 8x49 G.H5 E 392 G.H5.24
Polar TM6 K 244 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 244 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 244 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL3 M 234 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 M 234 - G.H5 R 385 G.H5.17
Polar H8 N 309 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 N 309 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM6 T 248 6x36 G.H5 L 393 G.H5.25
Ionic H8 E 308 8x48 G.H5 R 389 G.H5.21
Polar H8 E 308 8x48 G.H5 R 389 G.H5.21
Hydrophobic H8 E 308 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 E 308 8x48 G.H5 R 389 G.H5.21
Hydrophobic TM3 R 133 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 245 6x33 G.H5 L 388 G.H5.20
Van-der-waals ICL2 S 143 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 231 5x69 G.H5 D 381 G.H5.13
Van-der-waals TM5 L 231 5x69 G.H5 D 381 G.H5.13
Hydrophobic TM3 I 137 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 137 3x54 G.H5 L 388 G.H5.20
Hydrophobic H8 K 312 8x52 G.h4s6 R 356 G.h4s6.12
Polar TM5 H 226 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 226 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 226 5x64 G.H5 Q 384 G.H5.16
Polar TM6 S 238 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 S 238 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 S 238 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 K 237 6x25 G.h4s6 Y 358 G.h4s6.20
Ionic ICL2 R 141 34x51 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 141 34x51 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 141 34x51 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 141 34x51 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM6 S 241 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 S 241 6x29 G.H5 L 394 G.H5.26
Polar ICL2 R 147 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 147 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 147 34x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 S 140 34x50 G.H5 I 383 G.H5.15
Polar ICL2 R 147 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 147 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 147 34x57 G.H5 Y 391 G.H5.23