Gz - GAL1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 A 136 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 136 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 R 141 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 R 141 34x51 G.S3 L 195 G.S3.01
Polar TM6 K 237 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 K 237 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 K 237 6x25 G.h4s6 E 316 G.h4s6.09
Ionic ICL2 R 142 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 142 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 142 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 142 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM5 L 227 5x65 G.H5 I 345 G.H5.16
Van-der-waals TM5 L 227 5x65 G.H5 I 345 G.H5.16
Hydrophobic ICL2 R 141 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 R 141 34x51 G.H5 F 337 G.H5.08
Polar TM6 S 238 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 T 245 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 245 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 245 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL3 M 234 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 M 234 - G.S6 Y 321 G.S6.02
Polar TM6 S 235 6x23 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 235 6x23 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 235 6x23 G.h4s6 E 319 G.h4s6.12
Polar TM2 S 68 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 S 68 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 S 68 2x37 G.H5 Y 351 G.H5.22
Polar TM6 K 237 6x25 G.h4s6 T 317 G.h4s6.10
Hydrophobic TM6 K 237 6x25 G.h4s6 T 317 G.h4s6.10
Van-der-waals TM6 K 237 6x25 G.h4s6 T 317 G.h4s6.10
Van-der-waals TM6 S 241 6x29 G.H5 C 355 G.H5.26
Hydrophobic ICL2 R 141 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 R 141 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic H8 S 307 8x47 G.H5 G 353 G.H5.24
Polar TM6 S 241 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM3 A 136 3x53 G.H5 I 352 G.H5.23
Polar H8 N 309 8x49 G.H5 Y 351 G.H5.22
Polar ICL2 S 144 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 144 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 144 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 137 3x54 G.H5 I 352 G.H5.23
Hydrophobic ICL3 M 234 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 M 234 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 I 137 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM5 L 231 5x69 G.H5 D 342 G.H5.13
Van-der-waals TM5 L 231 5x69 G.H5 D 342 G.H5.13
Hydrophobic TM6 K 244 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 244 6x32 G.H5 C 355 G.H5.26
Polar ICL2 S 145 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 145 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 145 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL1 P 66 - G.HN R 24 G.HN.48
Hydrophobic TM3 R 133 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 R 147 34x57 G.H5 Y 351 G.H5.22
Hydrophobic TM4 V 148 4x38 G.HN Q 28 G.HN.52
Hydrophobic TM5 H 226 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM3 I 137 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM6 K 237 6x25 G.h4s6 E 319 G.h4s6.12
Polar TM3 R 133 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 I 352 G.H5.23
Hydrophobic ICL3 M 234 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 M 234 - G.H5 Q 346 G.H5.17
Hydrophobic TM2 T 70 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM5 L 227 5x65 G.H5 L 349 G.H5.20
Polar ICL2 R 141 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 R 141 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 R 147 34x57 G.H5 I 352 G.H5.23
Van-der-waals ICL2 R 147 34x57 G.H5 I 352 G.H5.23
Hydrophobic TM5 L 231 5x69 G.H5 I 345 G.H5.16
Polar H8 N 309 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 N 309 8x49 G.H5 K 350 G.H5.21
Hydrophobic ICL2 S 144 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 S 144 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 I 137 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 137 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 T 248 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 248 6x36 G.H5 L 354 G.H5.25
Polar ICL1 P 66 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 S 140 34x50 G.H5 I 345 G.H5.16
Polar TM6 K 237 6x25 G.h4s6 K 318 G.h4s6.11
Van-der-waals TM6 K 237 6x25 G.h4s6 K 318 G.h4s6.11
Hydrophobic TM6 V 249 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL2 S 140 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM6 T 245 6x33 G.H5 L 349 G.H5.20