G13 - GAL3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 R 131 34x54 G.S1 V 49 G.S1.02
Van-der-waals ICL2 R 131 34x54 G.S1 V 49 G.S1.02
Hydrophobic ICL2 P 127 34x50 G.H5 I 366 G.H5.15
Van-der-waals ICL2 P 127 34x50 G.H5 I 366 G.H5.15
Polar ICL2 R 131 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 R 131 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 R 131 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic TM6 A 233 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 233 6x33 G.H5 M 375 G.H5.24
Hydrophobic TM6 A 233 6x33 G.H5 L 371 G.H5.20
Polar ICL2 P 127 34x50 G.H5 N 370 G.H5.19
Polar ICL2 R 134 34x57 G.H5 N 370 G.H5.19
Hydrophobic TM2 I 61 2x43 G.H5 L 376 G.H5.25
Hydrophobic ICL2 L 128 34x51 G.H5 F 359 G.H5.08
Van-der-waals ICL2 L 128 34x51 G.H5 F 359 G.H5.08
Polar TM6 R 232 6x32 G.H5 Q 377 G.H5.26
Hydrophobic TM6 R 232 6x32 G.H5 Q 377 G.H5.26
Van-der-waals TM6 R 232 6x32 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 L 128 34x51 G.S3 V 216 G.S3.01
Polar ICL2 R 131 34x54 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 R 131 34x54 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 R 131 34x54 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 V 124 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM3 V 124 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 124 3x54 G.H5 L 367 G.H5.16
Hydrophobic ICL2 L 128 34x51 G.S3 F 218 G.S3.03
Hydrophobic TM6 M 237 6x37 G.H5 L 374 G.H5.23
Hydrophobic TM6 A 236 6x36 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 236 6x36 G.H5 M 375 G.H5.24
Polar ICL2 R 129 34x52 G.s2s3 K 214 G.s2s3.01
Van-der-waals ICL2 R 129 34x52 G.s2s3 K 214 G.s2s3.01
Ionic TM2 E 52 2x34 G.HN K 42 G.HN.51
Polar TM2 E 52 2x34 G.HN K 42 G.HN.51
Van-der-waals TM2 E 52 2x34 G.HN K 42 G.HN.51
Hydrophobic ICL2 P 127 34x50 G.H5 L 367 G.H5.16
Hydrophobic TM6 T 230 6x30 G.H5 L 371 G.H5.20
Polar TM3 A 123 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 123 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 A 123 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM6 A 229 6x29 G.H5 H 368 G.H5.17
Polar H8 S 295 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 S 295 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 S 295 8x47 G.H5 L 376 G.H5.25
Polar TM2 G 54 2x36 G.hns1 K 46 G.hns1.02
Van-der-waals TM2 G 54 2x36 G.hns1 K 46 G.hns1.02
Hydrophobic TM4 T 135 4x38 G.HN T 43 G.HN.52
Van-der-waals TM4 T 135 4x38 G.HN T 43 G.HN.52
Hydrophobic TM7 Y 291 7x53 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 291 7x53 G.H5 L 376 G.H5.25
Hydrophobic TM6 R 232 6x32 G.H5 M 375 G.H5.24
Van-der-waals TM6 R 232 6x32 G.H5 M 375 G.H5.24
Polar ICL2 R 131 34x54 G.hns1 V 45 G.hns1.01
Polar H8 H 297 8x49 G.H5 Q 377 G.H5.26
Hydrophobic TM7 A 292 7x54 G.H5 L 376 G.H5.25
Hydrophobic ICL2 R 131 34x54 G.H5 I 366 G.H5.15
Hydrophobic TM3 V 124 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 V 124 3x54 G.H5 L 374 G.H5.23
Hydrophobic TM5 L 211 5x65 G.H5 L 371 G.H5.20
Polar H8 R 296 8x48 G.H5 L 376 G.H5.25
Van-der-waals H8 R 296 8x48 G.H5 L 376 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 K 363 G.H5.12
Van-der-waals ICL2 P 127 34x50 G.H5 K 363 G.H5.12
Polar ICL2 R 131 34x54 G.S1 L 48 G.S1.01
Hydrophobic ICL2 R 131 34x54 G.S1 L 48 G.S1.01
Van-der-waals ICL2 R 131 34x54 G.S1 L 48 G.S1.01
Hydrophobic H8 R 296 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 R 296 8x48 G.H5 Q 377 G.H5.26
Hydrophobic TM3 A 123 3x53 G.H5 L 374 G.H5.23
Polar H8 H 297 8x49 G.H5 L 376 G.H5.25
Van-der-waals H8 H 297 8x49 G.H5 L 376 G.H5.25
Hydrophobic ICL2 R 129 34x52 G.S3 V 216 G.S3.01
Hydrophobic ICL2 L 128 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 128 34x51 G.H5 I 366 G.H5.15
Hydrophobic ICL2 L 128 34x51 G.S1 V 49 G.S1.02
Polar ICL2 A 132 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 A 132 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 A 132 34x55 G.hns1 R 47 G.hns1.03
Ionic TM2 E 52 2x34 G.hns1 K 46 G.hns1.02
Hydrophobic TM5 F 210 5x64 G.H5 L 367 G.H5.16
Hydrophobic ICL2 L 128 34x51 G.H5 V 362 G.H5.11
Polar TM3 R 120 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 L 374 G.H5.23
Hydrophobic ICL2 L 128 34x51 G.H5 K 363 G.H5.12
Hydrophobic TM7 V 290 7x52 G.H5 L 376 G.H5.25
Van-der-waals TM7 V 290 7x52 G.H5 L 376 G.H5.25
Ionic TM6 R 226 6x26 G.H5 D 364 G.H5.13
Polar TM6 R 226 6x26 G.H5 D 364 G.H5.13
Hydrophobic TM6 R 226 6x26 G.H5 D 364 G.H5.13
Van-der-waals TM6 R 226 6x26 G.H5 D 364 G.H5.13