Gt2 -
GHRH receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 24.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | K | 310 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | K | 310 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | K | 310 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Polar | TM3 | A | 232 | 3x59 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | A | 232 | 3x59 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM3 | A | 232 | 3x59 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | S | 235 | - | G.S1 | T | 33 | G.S1.01 |
Van-der-waals | ICL2 | S | 235 | - | G.S1 | T | 33 | G.S1.01 |
Hydrophobic | H8 | T | 385 | 8x52 | G.h4s6 | V | 316 | G.h4s6.10 |
Polar | ICL2 | T | 234 | - | G.HN | A | 27 | G.HN.51 |
Polar | ICL2 | S | 237 | - | G.hns1 | E | 30 | G.hns1.01 |
Polar | TM3 | S | 233 | 3x60 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | S | 233 | 3x60 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM3 | S | 233 | 3x60 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM5 | I | 303 | 5x57 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | T | 234 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | T | 234 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | L | 227 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | S | 330 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 330 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | R | 161 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | K | 310 | 5x64 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | L | 307 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | W | 408 | - | G.hgh4 | F | 287 | G.hgh4.02 |
Hydrophobic | TM3 | L | 227 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | L | 227 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL2 | T | 234 | - | G.HN | K | 29 | G.HN.53 |
Hydrophobic | ICL2 | T | 234 | - | G.HN | K | 29 | G.HN.53 |
Van-der-waals | ICL2 | T | 234 | - | G.HN | K | 29 | G.HN.53 |
Polar | ICL2 | S | 235 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | S | 235 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | S | 235 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM2 | R | 161 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | R | 161 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | R | 161 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM6 | L | 334 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 334 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Polar | H8 | R | 403 | 8x70 | G.H3 | N | 251 | G.H3.10 |
Hydrophobic | H8 | R | 403 | 8x70 | G.H3 | N | 251 | G.H3.10 |
Van-der-waals | H8 | R | 403 | 8x70 | G.H3 | N | 251 | G.H3.10 |
Aromatic | C-term | W | 408 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | C-term | W | 408 | - | G.H3 | H | 244 | G.H3.03 |
Van-der-waals | C-term | W | 408 | - | G.H3 | H | 244 | G.H3.03 |
Ionic | C-term | R | 413 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | TM6 | R | 326 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | L | 230 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | L | 230 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | S | 233 | 3x60 | G.HN | A | 27 | G.HN.51 |
Van-der-waals | TM3 | S | 233 | 3x60 | G.HN | A | 27 | G.HN.51 |
Hydrophobic | TM2 | R | 161 | 2x46 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | R | 161 | 2x46 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | R | 403 | 8x70 | G.h4s6 | M | 312 | G.h4s6.03 |
Van-der-waals | H8 | R | 403 | 8x70 | G.h4s6 | M | 312 | G.h4s6.03 |
Polar | H8 | R | 403 | 8x70 | G.h4s6 | L | 310 | G.h4s6.01 |
Hydrophobic | H8 | R | 403 | 8x70 | G.h4s6 | L | 310 | G.h4s6.01 |
Van-der-waals | H8 | R | 403 | 8x70 | G.h4s6 | L | 310 | G.h4s6.01 |
Polar | TM3 | S | 233 | 3x60 | G.HN | D | 28 | G.HN.52 |
Hydrophobic | TM3 | S | 233 | 3x60 | G.HN | D | 28 | G.HN.52 |
Van-der-waals | TM3 | S | 233 | 3x60 | G.HN | D | 28 | G.HN.52 |
Polar | ICL2 | T | 234 | - | G.HN | D | 28 | G.HN.52 |
Van-der-waals | ICL2 | T | 234 | - | G.HN | D | 28 | G.HN.52 |
Polar | TM7 | Y | 376 | 7x57 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM7 | Y | 376 | 7x57 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | Y | 376 | 7x57 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL2 | S | 235 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | ICL2 | S | 235 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | ICL2 | S | 235 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | TM3 | L | 231 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | L | 231 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Polar | TM3 | S | 233 | 3x60 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | S | 233 | 3x60 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM3 | S | 233 | 3x60 | G.hns1 | A | 31 | G.hns1.02 |
Aromatic | TM6 | K | 329 | 6x40 | G.H5 | F | 354 | G.H5.26 |
Polar | H8 | Q | 381 | 8x48 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | H8 | Q | 381 | 8x48 | G.H5 | K | 349 | G.H5.21 |
Polar | ICL2 | S | 235 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | S | 235 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | S | 235 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | L | 230 | 3x57 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM3 | L | 230 | 3x57 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM5 | L | 307 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | L | 307 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | T | 234 | - | G.S1 | T | 33 | G.S1.01 |
Hydrophobic | ICL2 | T | 234 | - | G.S1 | T | 33 | G.S1.01 |
Van-der-waals | ICL2 | T | 234 | - | G.S1 | T | 33 | G.S1.01 |
Polar | ICL2 | P | 236 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | P | 236 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | P | 236 | - | G.hns1 | K | 32 | G.hns1.03 |
Polar | TM2 | R | 161 | 2x46 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM2 | R | 161 | 2x46 | G.H5 | K | 349 | G.H5.21 |
Polar | ICL2 | T | 234 | - | G.S3 | N | 195 | G.S3.02 |
Hydrophobic | ICL2 | T | 234 | - | G.S3 | N | 195 | G.S3.02 |
Van-der-waals | ICL2 | T | 234 | - | G.S3 | N | 195 | G.S3.02 |
Ionic | TM5 | R | 309 | 5x63 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | TM5 | R | 309 | 5x63 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | TM5 | R | 309 | 5x63 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | T | 234 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | T | 234 | - | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL2 | T | 234 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | ICL2 | T | 234 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | ICL2 | T | 234 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | TM3 | L | 231 | 3x58 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM3 | L | 231 | 3x58 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | H8 | T | 385 | 8x52 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | ICL2 | P | 236 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | P | 236 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | P | 236 | - | G.hns1 | A | 31 | G.hns1.02 |