G15 -
ghrelin receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 87.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | L | 265 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | W | 359 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | W | 359 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | W | 359 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Ionic | TM5 | R | 242 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | R | 242 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | R | 242 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | R | 242 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM6 | H | 258 | 6x30 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | W | 359 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | W | 359 | - | G.H3 | L | 264 | G.H3.15 |
Ionic | TM6 | R | 254 | 6x26 | G.H5 | D | 361 | G.H5.13 |
Polar | TM6 | R | 254 | 6x26 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | T | 360 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | L | 351 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | L | 351 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | ICL2 | K | 152 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | K | 152 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Hydrophobic | TM7 | M | 326 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | A | 151 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | A | 151 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | A | 151 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM7 | Y | 323 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM7 | Y | 323 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | Y | 323 | 7x53 | G.H5 | N | 372 | G.H5.24 |
Polar | TM6 | T | 261 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | T | 261 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | S | 362 | - | G.H3 | A | 256 | G.H3.07 |
Van-der-waals | C-term | S | 362 | - | G.H3 | A | 256 | G.H3.07 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Polar | H8 | K | 328 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | H8 | K | 328 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | H8 | K | 328 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | C-term | T | 360 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | T | 360 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | T | 360 | - | G.H2 | K | 213 | G.H2.01 |
Ionic | H8 | K | 329 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | K | 329 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | H8 | K | 329 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | K | 329 | 8x49 | G.H5 | D | 369 | G.H5.21 |
Polar | C-term | S | 362 | - | G.H3 | E | 253 | G.H3.04 |
Hydrophobic | C-term | S | 362 | - | G.H3 | E | 253 | G.H3.04 |
Van-der-waals | C-term | S | 362 | - | G.H3 | E | 253 | G.H3.04 |
Hydrophobic | C-term | W | 359 | - | G.H3 | I | 261 | G.H3.12 |
Hydrophobic | TM5 | L | 239 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | W | 359 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Van-der-waals | C-term | W | 359 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Aromatic | C-term | W | 359 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | C-term | W | 359 | - | G.H2 | W | 219 | G.H2.07 |
Van-der-waals | C-term | W | 359 | - | G.H2 | W | 219 | G.H2.07 |
Polar | ICL2 | P | 148 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM2 | T | 78 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 144 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM2 | T | 76 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Polar | ICL2 | K | 152 | 34x54 | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | ICL2 | K | 152 | 34x54 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | TM4 | T | 156 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | T | 156 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Polar | H8 | K | 328 | 8x48 | G.h4s6 | K | 331 | G.h4s6.13 |
Van-der-waals | H8 | K | 328 | 8x48 | G.h4s6 | K | 331 | G.h4s6.13 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 149 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | C-term | W | 359 | - | G.H3 | L | 257 | G.H3.08 |
Polar | H8 | K | 328 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Polar | H8 | K | 328 | 8x48 | G.h4s6 | G | 333 | G.h4s6.15 |
Polar | TM2 | T | 78 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Ionic | TM5 | D | 246 | 5x72 | G.H5 | K | 357 | G.H5.09 |
Polar | TM5 | D | 246 | 5x72 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM5 | D | 246 | 5x72 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | D | 246 | 5x72 | G.H5 | K | 357 | G.H5.09 |
Polar | ICL2 | K | 152 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | K | 152 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | K | 152 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | K | 152 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Polar | TM3 | R | 141 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 141 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM5 | R | 242 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | R | 242 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Polar | H8 | S | 327 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | S | 327 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | S | 327 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | M | 326 | 7x56 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | R | 254 | 6x26 | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | TM6 | R | 254 | 6x26 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | R | 254 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | R | 254 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM6 | M | 264 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | M | 264 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Polar | TM7 | N | 324 | 7x54 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | N | 324 | 7x54 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | R | 242 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | R | 242 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Polar | TM2 | N | 79 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM2 | N | 79 | 2x40 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 149 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Polar | ICL2 | K | 152 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | K | 152 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | K | 152 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | I | 364 | - | G.H3 | K | 252 | G.H3.03 |
Polar | C-term | S | 356 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | S | 356 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | S | 356 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | L | 351 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | L | 351 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | I | 364 | - | G.H3 | A | 256 | G.H3.07 |
Van-der-waals | C-term | I | 364 | - | G.H3 | A | 256 | G.H3.07 |
Hydrophobic | TM6 | T | 261 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | L | 351 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | L | 351 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | V | 153 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | V | 153 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | V | 153 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |