Gz - ghrelin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 M 264 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM2 T 78 2x39 G.H5 I 352 G.H5.23
Hydrophobic ICL2 L 149 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic TM3 R 141 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM4 K 157 4x39 G.hns1 R 31 G.hns1.02
Polar TM6 H 258 6x30 G.H5 Q 346 G.H5.17
Van-der-waals TM6 H 258 6x30 G.H5 Q 346 G.H5.17
Hydrophobic ICL2 P 148 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 148 34x50 G.H5 I 344 G.H5.15
Hydrophobic C-term T 360 - G.H2 E 208 G.H2.03
Van-der-waals C-term T 360 - G.H2 E 208 G.H2.03
Hydrophobic ICL2 K 152 34x54 G.H5 I 344 G.H5.15
Ionic TM6 R 254 6x26 G.H5 D 342 G.H5.13
Polar TM6 R 254 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 R 254 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 254 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 238 5x64 G.H5 I 345 G.H5.16
Polar TM2 T 78 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM6 L 253 6x25 G.h4s6 K 318 G.h4s6.11
Hydrophobic C-term K 347 - G.h3s5 I 261 G.h3s5.01
Hydrophobic TM2 T 76 2x37 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 P 148 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 148 34x50 G.H5 T 341 G.H5.12
Ionic TM5 R 242 5x68 G.H5 D 342 G.H5.13
Polar TM5 R 242 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 R 242 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 242 5x68 G.H5 D 342 G.H5.13
Polar C-term W 359 - G.H3 S 253 G.H3.11
Hydrophobic C-term W 359 - G.H3 S 253 G.H3.11
Van-der-waals C-term W 359 - G.H3 S 253 G.H3.11
Hydrophobic TM5 L 239 5x65 G.H5 I 345 G.H5.16
Polar TM5 R 242 5x68 G.H5 T 341 G.H5.12
Hydrophobic TM5 R 242 5x68 G.H5 T 341 G.H5.12
Van-der-waals TM5 R 242 5x68 G.H5 T 341 G.H5.12
Hydrophobic TM7 M 326 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 M 326 7x56 G.H5 G 353 G.H5.24
Hydrophobic ICL2 L 149 34x51 G.S1 I 34 G.S1.02
Hydrophobic ICL3 V 248 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 V 248 - G.H4 Q 305 G.H4.12
Hydrophobic TM6 T 261 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 T 261 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM7 M 326 7x56 G.H5 C 355 G.H5.26
Hydrophobic TM6 R 254 6x26 G.S6 Y 321 G.S6.02
Polar C-term K 347 - G.H3 N 258 G.H3.16
Van-der-waals C-term K 347 - G.H3 N 258 G.H3.16
Hydrophobic TM5 R 242 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 242 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 K 152 34x54 G.S3 L 195 G.S3.01
Hydrophobic C-term W 359 - G.H2 K 210 G.H2.05
Van-der-waals C-term W 359 - G.H2 K 210 G.H2.05
Polar C-term W 359 - G.H2 R 209 G.H2.04
Aromatic C-term W 359 - G.H2 R 209 G.H2.04
Hydrophobic C-term W 359 - G.H2 R 209 G.H2.04
Van-der-waals C-term W 359 - G.H2 R 209 G.H2.04
Hydrophobic TM3 A 144 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 A 144 3x53 G.H5 I 352 G.H5.23
Hydrophobic H8 S 327 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM6 L 253 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 L 253 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic C-term W 359 - G.H3 N 257 G.H3.15
Van-der-waals C-term W 359 - G.H3 N 257 G.H3.15
Hydrophobic TM3 I 145 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 I 145 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM5 L 239 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM6 R 254 6x26 G.H5 Q 346 G.H5.17
Van-der-waals TM6 R 254 6x26 G.H5 Q 346 G.H5.17
Hydrophobic C-term S 349 - G.H3 W 259 G.H3.17
Van-der-waals C-term S 349 - G.H3 W 259 G.H3.17
Hydrophobic C-term A 358 - G.H3 R 249 G.H3.07
Van-der-waals C-term A 358 - G.H3 R 249 G.H3.07
Polar TM6 T 261 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 261 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 149 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 149 34x51 G.S3 L 195 G.S3.01
Polar H8 K 329 8x49 G.H5 Y 351 G.H5.22
Hydrophobic TM6 H 258 6x30 G.H5 L 349 G.H5.20
Hydrophobic TM3 I 145 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 349 G.H5.20
Ionic C-term E 361 - G.H2 R 209 G.H2.04
Polar C-term E 361 - G.H2 R 209 G.H2.04
Hydrophobic C-term E 361 - G.H2 R 209 G.H2.04
Van-der-waals C-term E 361 - G.H2 R 209 G.H2.04
Hydrophobic ICL2 V 153 34x55 G.S3 L 195 G.S3.01
Van-der-waals ICL2 V 153 34x55 G.S3 L 195 G.S3.01
Polar TM3 A 144 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 348 G.H5.19
Ionic TM6 R 254 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 254 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 254 6x26 G.h4s6 E 319 G.h4s6.12
Polar ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 153 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic C-term W 359 - G.H2 I 213 G.H2.08
Hydrophobic TM6 L 253 6x25 G.h4s6 T 317 G.h4s6.10
Polar TM3 R 141 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 I 145 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 265 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 148 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 V 153 34x55 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 V 153 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 L 149 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 149 34x51 G.H5 I 344 G.H5.15