G12 -
GIP receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | G | 249 | - | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | ICL2 | G | 249 | - | G.s2s3 | K | 220 | G.s2s3.02 |
Van-der-waals | ICL2 | G | 249 | - | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | TM6 | T | 345 | 6x44 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | T | 345 | 6x44 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | K | 324 | 5x64 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | K | 324 | 5x64 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL2 | V | 248 | - | G.S2 | I | 218 | G.S2.08 |
Van-der-waals | ICL2 | V | 248 | - | G.S2 | I | 218 | G.S2.08 |
Ionic | TM5 | K | 324 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | K | 324 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | K | 324 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | K | 324 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Ionic | TM6 | R | 338 | 6x37 | G.H5 | E | 373 | G.H5.18 |
Polar | TM6 | R | 338 | 6x37 | G.H5 | E | 373 | G.H5.18 |
Polar | TM2 | R | 169 | 2x46 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM2 | R | 169 | 2x46 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM2 | R | 169 | 2x46 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM3 | L | 244 | 3x57 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | H8 | E | 398 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | E | 398 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM3 | L | 241 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | L | 241 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM5 | L | 321 | 5x61 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM5 | L | 321 | 5x61 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | L | 321 | 5x61 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL2 | V | 248 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | V | 248 | - | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | ICL2 | G | 249 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | G | 249 | - | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | ICL3 | M | 330 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | M | 330 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | TM3 | L | 245 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | L | 245 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | K | 324 | 5x64 | G.H5 | T | 369 | G.H5.14 |
Polar | TM2 | C | 167 | 2x44 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM2 | C | 167 | 2x44 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM2 | C | 167 | 2x44 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM3 | L | 244 | 3x57 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | L | 321 | 5x61 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM5 | L | 321 | 5x61 | G.H5 | K | 376 | G.H5.21 |
Ionic | TM5 | R | 328 | 5x68 | G.H5 | E | 373 | G.H5.18 |
Polar | TM5 | R | 328 | 5x68 | G.H5 | E | 373 | G.H5.18 |
Hydrophobic | TM5 | R | 328 | 5x68 | G.H5 | E | 373 | G.H5.18 |
Van-der-waals | TM5 | R | 328 | 5x68 | G.H5 | E | 373 | G.H5.18 |
Polar | TM6 | S | 342 | 6x41 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM6 | S | 342 | 6x41 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | ICL3 | M | 330 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | M | 330 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | TM2 | T | 168 | 2x45 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM2 | T | 168 | 2x45 | G.HN | R | 52 | G.HN.52 |
Ionic | ICL2 | E | 253 | - | G.HN | R | 52 | G.HN.52 |
Polar | ICL2 | E | 253 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL2 | E | 253 | - | G.HN | R | 52 | G.HN.52 |
Van-der-waals | ICL2 | E | 253 | - | G.HN | R | 52 | G.HN.52 |
Polar | TM7 | Y | 392 | 7x57 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM7 | Y | 392 | 7x57 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM7 | Y | 392 | 7x57 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | V | 248 | - | G.s2s3 | K | 220 | G.s2s3.02 |
Van-der-waals | ICL2 | V | 248 | - | G.s2s3 | K | 220 | G.s2s3.02 |
Polar | TM5 | R | 328 | 5x68 | G.H5 | T | 369 | G.H5.14 |
Hydrophobic | TM5 | R | 328 | 5x68 | G.H5 | T | 369 | G.H5.14 |
Van-der-waals | TM5 | R | 328 | 5x68 | G.H5 | T | 369 | G.H5.14 |
Hydrophobic | TM6 | L | 346 | 6x45 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | L | 346 | 6x45 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | V | 248 | - | G.s2s3 | K | 219 | G.s2s3.01 |
Van-der-waals | ICL2 | V | 248 | - | G.s2s3 | K | 219 | G.s2s3.01 |
Polar | ICL2 | S | 251 | - | G.hns1 | R | 56 | G.hns1.03 |
Polar | H8 | N | 396 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | N | 396 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | N | 396 | 8x47 | G.H5 | Q | 381 | G.H5.26 |
Ionic | H8 | E | 398 | 8x49 | G.hns1 | R | 55 | G.hns1.02 |
Polar | H8 | E | 398 | 8x49 | G.hns1 | R | 55 | G.hns1.02 |
Polar | TM3 | S | 243 | 3x56 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | G | 249 | - | G.S3 | P | 222 | G.S3.02 |
Ionic | ICL2 | E | 252 | - | G.hns1 | R | 56 | G.hns1.03 |
Polar | ICL2 | E | 252 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | E | 252 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | E | 252 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | C-term | Y | 465 | - | G.H3 | E | 278 | G.H3.10 |
Van-der-waals | C-term | Y | 465 | - | G.H3 | E | 278 | G.H3.10 |
Polar | TM2 | R | 169 | 2x46 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM2 | R | 169 | 2x46 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM2 | R | 169 | 2x46 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | L | 241 | 3x54 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM3 | L | 241 | 3x54 | G.H5 | M | 379 | G.H5.24 |
Aromatic | TM5 | R | 328 | 5x68 | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | TM5 | R | 328 | 5x68 | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | TM5 | R | 328 | 5x68 | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | TM3 | L | 244 | 3x57 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM4 | F | 256 | 4x43 | G.HN | R | 52 | G.HN.52 |
Polar | TM5 | I | 320 | 5x60 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | I | 320 | 5x60 | G.H5 | Q | 372 | G.H5.17 |
Polar | ICL3 | Q | 329 | - | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | H8 | N | 396 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | Y | 392 | 7x57 | G.H5 | Q | 381 | G.H5.26 |
Ionic | ICL2 | E | 253 | - | G.HN | R | 49 | G.HN.49 |
Polar | ICL2 | E | 253 | - | G.HN | R | 49 | G.HN.49 |
Hydrophobic | ICL2 | E | 253 | - | G.HN | R | 49 | G.HN.49 |
Van-der-waals | ICL2 | E | 253 | - | G.HN | R | 49 | G.HN.49 |
Polar | ICL2 | G | 250 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | G | 250 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | G | 250 | - | G.hns1 | R | 56 | G.hns1.03 |