G15 -
GIP receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | ICL2 | E | 253 | - | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL2 | E | 253 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | E | 253 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | E | 253 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | G | 249 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM6 | R | 338 | 6x37 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM5 | I | 320 | 5x60 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | I | 320 | 5x60 | G.H5 | L | 364 | G.H5.16 |
Polar | H8 | N | 396 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | H8 | N | 396 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | N | 396 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Polar | C-term | Y | 465 | - | G.h2s4 | N | 225 | G.h2s4.03 |
Hydrophobic | C-term | Y | 465 | - | G.h2s4 | N | 225 | G.h2s4.03 |
Van-der-waals | C-term | Y | 465 | - | G.h2s4 | N | 225 | G.h2s4.03 |
Hydrophobic | ICL2 | S | 251 | - | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | TM6 | T | 345 | 6x44 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | T | 345 | 6x44 | G.H5 | L | 373 | G.H5.25 |
Ionic | TM2 | R | 169 | 2x46 | G.H5 | E | 370 | G.H5.22 |
Polar | TM2 | R | 169 | 2x46 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM2 | R | 169 | 2x46 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | R | 169 | 2x46 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL2 | V | 248 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | TM6 | R | 341 | 6x40 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | R | 341 | 6x40 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | V | 248 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | V | 248 | - | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | V | 248 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM5 | K | 324 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | K | 324 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | L | 245 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | L | 245 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Polar | H8 | K | 397 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | K | 397 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | K | 397 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Polar | TM5 | R | 328 | 5x68 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM5 | R | 328 | 5x68 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | ICL1 | H | 166 | 12x51 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | V | 248 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | V | 248 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM3 | L | 241 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | L | 325 | 5x65 | G.H5 | L | 374 | G.H5.26 |
Ionic | TM5 | K | 324 | 5x64 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | K | 324 | 5x64 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | K | 324 | 5x64 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | K | 324 | 5x64 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM2 | R | 169 | 2x46 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM2 | R | 169 | 2x46 | G.H5 | Y | 367 | G.H5.19 |
Ionic | H8 | K | 397 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | K | 397 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | K | 397 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | TM5 | L | 321 | 5x61 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | L | 321 | 5x61 | G.H5 | L | 368 | G.H5.20 |
Polar | TM6 | S | 342 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | S | 342 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | S | 342 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM7 | Y | 392 | 7x57 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM7 | Y | 392 | 7x57 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | L | 241 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | L | 241 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM5 | R | 328 | 5x68 | G.h4s6 | R | 337 | G.h4s6.19 |
Hydrophobic | TM5 | R | 328 | 5x68 | G.h4s6 | R | 337 | G.h4s6.19 |
Van-der-waals | TM5 | R | 328 | 5x68 | G.h4s6 | R | 337 | G.h4s6.19 |
Hydrophobic | ICL2 | G | 249 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | G | 249 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | TM5 | R | 328 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | R | 328 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | ICL2 | G | 250 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | TM7 | I | 395 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM7 | I | 395 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | I | 395 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM2 | R | 169 | 2x46 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM2 | R | 169 | 2x46 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | V | 248 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | V | 248 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | V | 248 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | V | 248 | - | G.H5 | R | 360 | G.H5.12 |
Ionic | ICL2 | E | 253 | - | G.HN | K | 37 | G.HN.52 |
Polar | ICL2 | E | 253 | - | G.HN | K | 37 | G.HN.52 |
Hydrophobic | ICL2 | E | 253 | - | G.HN | K | 37 | G.HN.52 |
Van-der-waals | ICL2 | E | 253 | - | G.HN | K | 37 | G.HN.52 |
Polar | TM5 | K | 324 | 5x64 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM6 | L | 346 | 6x45 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | L | 346 | 6x45 | G.H5 | L | 373 | G.H5.25 |
Polar | TM5 | R | 328 | 5x68 | G.h4s6 | S | 336 | G.h4s6.18 |
Van-der-waals | TM5 | R | 328 | 5x68 | G.h4s6 | S | 336 | G.h4s6.18 |
Hydrophobic | TM3 | L | 244 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | L | 244 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | G | 249 | - | G.hns1 | G | 41 | G.hns1.03 |
Ionic | TM6 | D | 334 | 6x33 | G.h4s6 | K | 331 | G.h4s6.13 |
Polar | TM5 | K | 324 | 5x64 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | K | 324 | 5x64 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | K | 324 | 5x64 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | ICL2 | G | 249 | - | G.S3 | N | 203 | G.S3.02 |
Van-der-waals | ICL2 | G | 249 | - | G.S3 | N | 203 | G.S3.02 |
Hydrophobic | TM3 | Y | 240 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | Y | 240 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM3 | L | 245 | 3x58 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM3 | L | 245 | 3x58 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM3 | L | 245 | 3x58 | G.H5 | R | 360 | G.H5.12 |
Polar | ICL2 | G | 249 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | G | 249 | - | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | G | 249 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM2 | H | 173 | 2x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | V | 246 | 3x59 | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | C | 466 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | C | 466 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | C-term | C | 466 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | H8 | N | 396 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | N | 396 | 8x47 | G.H5 | N | 372 | G.H5.24 |