G12 - GLP-1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 K 334 5x64 G.H5 D 368 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 368 G.H5.13
Hydrophobic H8 E 408 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM3 F 257 3x60 G.H5 K 367 G.H5.12
Hydrophobic TM3 L 251 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 251 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 L 356 6x45 G.H5 I 378 G.H5.23
Hydrophobic ICL2 V 259 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 V 259 - G.H5 F 363 G.H5.08
Hydrophobic TM4 E 262 4x39 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 E 262 4x39 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 Q 263 4x40 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 Q 263 4x40 G.hns1 R 56 G.hns1.03
Polar ICL2 S 258 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 S 258 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 S 258 - G.H5 K 367 G.H5.12
Ionic TM2 R 176 2x46 G.H5 D 377 G.H5.22
Polar TM2 R 176 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 176 2x46 G.H5 D 377 G.H5.22
Polar TM7 Y 402 7x57 G.H5 I 378 G.H5.23
Hydrophobic TM7 Y 402 7x57 G.H5 I 378 G.H5.23
Van-der-waals TM7 Y 402 7x57 G.H5 I 378 G.H5.23
Hydrophobic H8 N 406 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 406 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 352 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 352 6x41 G.H5 M 379 G.H5.24
Hydrophobic TM3 L 255 3x58 G.H5 K 367 G.H5.12
Van-der-waals TM3 L 255 3x58 G.H5 K 367 G.H5.12
Hydrophobic TM5 V 331 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM4 W 264 4x41 G.hns1 R 56 G.hns1.03
Polar TM2 T 175 2x45 G.hns1 R 55 G.hns1.02
Polar ICL1 H 173 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 H 173 12x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 H 173 12x51 G.hns1 R 55 G.hns1.02
Polar H8 N 407 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 407 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 407 8x48 G.H5 Q 381 G.H5.26
Polar TM3 A 256 3x59 G.H5 K 367 G.H5.12
Hydrophobic TM3 A 256 3x59 G.H5 K 367 G.H5.12
Van-der-waals TM3 A 256 3x59 G.H5 K 367 G.H5.12
Hydrophobic TM7 Y 402 7x57 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 402 7x57 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 255 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 255 3x58 G.H5 L 375 G.H5.20
Hydrophobic TM2 C 174 2x44 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 C 174 2x44 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 V 259 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 V 259 - G.s2s3 K 219 G.s2s3.01
Hydrophobic TM3 L 255 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 L 371 G.H5.16
Polar TM4 S 261 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 S 261 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 S 261 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 E 262 4x39 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 E 262 4x39 G.hns1 R 55 G.hns1.02
Polar TM6 R 348 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 348 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 348 6x37 G.H5 Q 381 G.H5.26
Polar TM4 Q 263 4x40 G.HN R 52 G.HN.52
Hydrophobic TM4 Q 263 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 Q 263 4x40 G.HN R 52 G.HN.52
Hydrophobic TM5 V 327 5x57 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 359 6x48 G.H5 I 378 G.H5.23
Polar TM2 Y 178 2x48 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 Y 178 2x48 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 Y 178 2x48 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 L 254 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 N 374 G.H5.19
Polar TM4 Q 263 4x40 G.HN R 49 G.HN.49
Hydrophobic ICL2 V 259 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 259 - G.S3 I 221 G.S3.01
Hydrophobic TM2 R 176 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM5 V 331 5x61 G.H5 L 375 G.H5.20
Hydrophobic TM7 L 401 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 401 7x56 G.H5 L 380 G.H5.25