G15 - GLP-1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 K 334 5x64 G.H5 L 368 G.H5.20
Hydrophobic C-term T 440 - G.H2 K 217 G.H2.05
Van-der-waals C-term T 440 - G.H2 K 217 G.H2.05
Hydrophobic C-term L 436 - G.H3 W 266 G.H3.17
Hydrophobic TM2 R 176 2x46 G.H5 I 371 G.H5.23
Van-der-waals TM2 R 176 2x46 G.H5 I 371 G.H5.23
Polar ICL1 R 170 12x48 G.HN M 1 G.HN.01
Van-der-waals ICL1 R 170 12x48 G.HN M 1 G.HN.01
Polar TM4 Q 263 4x40 G.HN K 37 G.HN.52
Hydrophobic TM4 Q 263 4x40 G.HN K 37 G.HN.52
Van-der-waals TM4 Q 263 4x40 G.HN K 37 G.HN.52
Hydrophobic C-term L 443 - G.H3 K 252 G.H3.03
Van-der-waals C-term L 443 - G.H3 K 252 G.H3.03
Hydrophobic C-term P 439 - G.H3 T 260 G.H3.11
Van-der-waals C-term P 439 - G.H3 T 260 G.H3.11
Hydrophobic ICL2 V 259 - G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 V 259 - G.s2s3 K 201 G.s2s3.02
Ionic TM5 K 334 5x64 G.H5 D 361 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 361 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 361 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 361 G.H5.13
Hydrophobic C-term L 443 - G.H3 A 256 G.H3.07
Polar C-term S 444 - G.s4h3 N 245 G.s4h3.11
Hydrophobic TM6 R 348 6x37 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 R 348 6x37 G.h4s6 R 335 G.h4s6.17
Hydrophobic C-term C 438 - G.H2 I 220 G.H2.08
Van-der-waals C-term C 438 - G.H2 I 220 G.H2.08
Hydrophobic C-term L 436 - G.H3 P 265 G.H3.16
Van-der-waals C-term L 436 - G.H3 P 265 G.H3.16
Hydrophobic C-term L 436 - G.H3 L 264 G.H3.15
Van-der-waals C-term L 436 - G.H3 L 264 G.H3.15
Hydrophobic TM3 L 251 3x54 G.H5 I 371 G.H5.23
Van-der-waals TM3 L 251 3x54 G.H5 I 371 G.H5.23
Hydrophobic TM3 L 255 3x58 G.H5 L 368 G.H5.20
Polar TM5 N 338 5x68 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 N 338 5x68 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 N 338 5x68 G.h4s6 R 338 G.h4s6.20
Polar C-term L 443 - G.H3 E 253 G.H3.04
Hydrophobic C-term L 443 - G.H3 E 253 G.H3.04
Hydrophobic C-term S 442 - G.H3 A 256 G.H3.07
Van-der-waals C-term S 442 - G.H3 A 256 G.H3.07
Hydrophobic TM3 L 255 3x58 G.H5 L 364 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 L 364 G.H5.16
Polar TM6 S 352 6x41 G.H5 L 373 G.H5.25
Hydrophobic TM6 S 352 6x41 G.H5 L 373 G.H5.25
Van-der-waals TM6 S 352 6x41 G.H5 L 373 G.H5.25
Hydrophobic TM2 R 176 2x46 G.H5 Y 367 G.H5.19
Hydrophobic TM3 L 255 3x58 G.H5 Y 367 G.H5.19
Hydrophobic TM5 L 335 5x65 G.H5 L 374 G.H5.26
Polar H8 N 407 8x48 G.H5 N 372 G.H5.24
Hydrophobic C-term C 458 - G.H3 P 265 G.H3.16
Van-der-waals C-term C 458 - G.H3 P 265 G.H3.16
Polar TM5 K 334 5x64 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 K 334 5x64 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM5 K 334 5x64 G.h4s6 R 338 G.h4s6.20
Polar C-term S 442 - G.H3 E 253 G.H3.04
Hydrophobic C-term S 442 - G.H3 E 253 G.H3.04
Van-der-waals C-term S 442 - G.H3 E 253 G.H3.04
Hydrophobic TM5 V 327 5x57 G.H5 L 373 G.H5.25
Hydrophobic C-term A 456 - G.H2 I 220 G.H2.08
Van-der-waals C-term A 456 - G.H2 I 220 G.H2.08
Hydrophobic TM5 I 330 5x60 G.H5 L 364 G.H5.16
Polar C-term P 439 - G.H2 R 216 G.H2.04
Hydrophobic C-term P 439 - G.H2 R 216 G.H2.04
Van-der-waals C-term P 439 - G.H2 R 216 G.H2.04
Hydrophobic C-term P 439 - G.H3 L 257 G.H3.08
Polar TM2 R 176 2x46 G.H5 E 370 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 E 370 G.H5.22
Van-der-waals TM2 R 176 2x46 G.H5 E 370 G.H5.22
Hydrophobic C-term A 456 - G.H3 W 266 G.H3.17
Van-der-waals C-term A 456 - G.H3 W 266 G.H3.17
Hydrophobic C-term A 460 - G.H3 P 265 G.H3.16
Hydrophobic TM3 L 251 3x54 G.H5 Y 367 G.H5.19
Van-der-waals TM3 L 251 3x54 G.H5 Y 367 G.H5.19
Hydrophobic C-term Y 454 - G.H2 I 220 G.H2.08
Van-der-waals C-term Y 454 - G.H2 I 220 G.H2.08
Polar C-term C 438 - G.H2 K 217 G.H2.05
Hydrophobic C-term C 438 - G.H2 K 217 G.H2.05
Hydrophobic TM6 L 356 6x45 G.H5 L 373 G.H5.25
Polar C-term C 458 - G.H3 W 266 G.H3.17
Hydrophobic C-term C 458 - G.H3 W 266 G.H3.17
Van-der-waals C-term C 458 - G.H3 W 266 G.H3.17
Polar TM7 V 405 7x60 G.H5 N 372 G.H5.24
Hydrophobic TM5 V 331 5x61 G.H5 L 368 G.H5.20
Hydrophobic TM5 V 331 5x61 G.H5 L 373 G.H5.25
Polar C-term T 440 - G.H2 R 216 G.H2.04
Van-der-waals C-term T 440 - G.H2 R 216 G.H2.04
Polar C-term S 442 - G.H3 L 257 G.H3.08
Hydrophobic C-term S 442 - G.H3 L 257 G.H3.08
Van-der-waals C-term S 442 - G.H3 L 257 G.H3.08
Hydrophobic C-term L 443 - G.s4h3 E 248 G.s4h3.14
Polar C-term S 452 - G.H2 K 217 G.H2.05
Hydrophobic C-term S 452 - G.H2 K 217 G.H2.05
Van-der-waals C-term S 452 - G.H2 K 217 G.H2.05
Hydrophobic ICL2 S 258 - G.H5 R 360 G.H5.12
Hydrophobic TM5 K 334 5x64 G.H5 L 364 G.H5.16
Van-der-waals TM5 K 334 5x64 G.H5 L 364 G.H5.16
Polar TM6 R 348 6x37 G.H5 L 374 G.H5.26
Hydrophobic TM6 R 348 6x37 G.H5 L 374 G.H5.26
Van-der-waals TM6 R 348 6x37 G.H5 L 374 G.H5.26
Polar C-term S 444 - G.s4h3 E 248 G.s4h3.14
Hydrophobic C-term S 444 - G.s4h3 E 248 G.s4h3.14
Van-der-waals C-term S 444 - G.s4h3 E 248 G.s4h3.14
Hydrophobic TM3 L 254 3x57 G.H5 Y 367 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 V 259 - G.S3 T 202 G.S3.01
Van-der-waals ICL2 V 259 - G.S3 T 202 G.S3.01
Hydrophobic C-term P 439 - G.H3 L 264 G.H3.15
Hydrophobic C-term P 439 - G.H2 W 219 G.H2.07