G12 - GLP-2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 292 - G.H5 K 367 G.H5.12
Ionic ICL2 E 296 - G.hns1 R 56 G.hns1.03
Polar ICL2 E 296 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 296 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 296 - G.hns1 R 56 G.hns1.03
Hydrophobic TM3 L 289 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 289 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 365 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 L 365 5x61 G.H5 M 379 G.H5.24
Hydrophobic ICL2 T 292 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 T 292 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 T 292 - G.H5 I 370 G.H5.15
Hydrophobic TM5 L 364 5x60 G.H5 L 375 G.H5.20
Hydrophobic TM3 L 289 3x58 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 293 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 T 292 - G.H5 F 363 G.H5.08
Polar TM3 L 288 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 288 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 288 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 293 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 293 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 L 364 5x60 G.H5 L 371 G.H5.16
Hydrophobic C-term L 530 - G.H2 Q 236 G.H2.05
Van-der-waals C-term L 530 - G.H2 Q 236 G.H2.05
Polar C-term E 535 - G.H3 K 284 G.H3.16
Hydrophobic C-term E 535 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 535 - G.H3 K 284 G.H3.16
Hydrophobic H8 N 440 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 440 8x47 G.H5 L 380 G.H5.25
Ionic C-term E 532 - G.h4s6 R 340 G.h4s6.09
Polar C-term E 532 - G.h4s6 R 340 G.h4s6.09
Hydrophobic C-term E 532 - G.h4s6 R 340 G.h4s6.09
Van-der-waals C-term E 532 - G.h4s6 R 340 G.h4s6.09
Polar TM6 K 385 6x40 G.H5 M 379 G.H5.24
Hydrophobic TM6 V 389 6x44 G.H5 L 380 G.H5.25
Hydrophobic TM7 Y 436 7x57 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 436 7x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 293 - G.S1 V 58 G.S1.02
Ionic C-term E 532 - G.H3 K 284 G.H3.16
Polar C-term E 532 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 532 - G.H3 K 284 G.H3.16
Polar C-term M 544 - G.hns1 R 55 G.hns1.02
Hydrophobic C-term M 544 - G.hns1 R 55 G.hns1.02
Van-der-waals C-term M 544 - G.hns1 R 55 G.hns1.02
Ionic C-term E 552 - G.HN R 41 G.HN.41
Polar C-term E 552 - G.HN R 41 G.HN.41
Hydrophobic TM3 L 285 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 285 3x54 G.H5 I 378 G.H5.23
Polar TM6 K 385 6x40 G.H5 L 380 G.H5.25
Van-der-waals TM6 K 385 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM7 Q 435 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 Q 435 7x56 G.H5 L 380 G.H5.25
Ionic TM2 R 210 2x46 G.H5 D 377 G.H5.22
Polar TM2 R 210 2x46 G.H5 D 377 G.H5.22
Hydrophobic ICL2 V 293 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 293 - G.S3 I 221 G.S3.01
Hydrophobic TM5 K 368 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 K 368 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM3 L 289 3x58 G.H5 L 375 G.H5.20
Hydrophobic TM5 K 368 5x64 G.H5 L 375 G.H5.20
Hydrophobic ICL3 H 372 - G.h4s6 P 345 G.h4s6.20
Polar C-term C 533 - G.H3 K 284 G.H3.16
Van-der-waals C-term C 533 - G.H3 K 284 G.H3.16
Polar C-term E 545 - G.HN R 51 G.HN.51
Van-der-waals C-term E 545 - G.HN R 51 G.HN.51
Polar TM6 R 382 6x37 G.H5 Q 381 G.H5.26
Polar C-term E 535 - G.H3 L 285 G.H3.17
Hydrophobic C-term E 535 - G.H3 L 285 G.H3.17
Van-der-waals C-term E 535 - G.H3 L 285 G.H3.17
Polar TM7 Y 436 7x57 G.H5 I 378 G.H5.23
Hydrophobic TM3 L 288 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM6 S 386 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 386 6x41 G.H5 M 379 G.H5.24
Ionic C-term E 549 - G.HN R 52 G.HN.52
Polar C-term E 549 - G.HN R 52 G.HN.52
Hydrophobic TM6 L 390 6x45 G.H5 I 378 G.H5.23
Hydrophobic C-term D 537 - G.h3s5 F 287 G.h3s5.01
Van-der-waals C-term D 537 - G.h3s5 F 287 G.h3s5.01
Polar ICL2 L 294 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 294 - G.hns1 R 56 G.hns1.03
Hydrophobic TM3 L 289 3x58 G.H5 I 378 G.H5.23
Polar ICL3 H 372 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 H 372 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 H 372 - G.H5 Q 372 G.H5.17
Polar TM3 E 290 3x59 G.H5 K 367 G.H5.12
Van-der-waals TM3 E 290 3x59 G.H5 K 367 G.H5.12
Ionic TM5 K 368 5x64 G.H5 D 368 G.H5.13
Polar TM5 K 368 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 368 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 368 5x64 G.H5 D 368 G.H5.13