Gi2 - GLP-2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 295 - G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 365 5x61 G.H5 F 355 G.H5.26
Hydrophobic TM3 L 288 3x57 G.H5 C 352 G.H5.23
Van-der-waals TM3 L 288 3x57 G.H5 C 352 G.H5.23
Hydrophobic C-term M 544 - G.s4h3 M 241 G.s4h3.14
Van-der-waals C-term M 544 - G.s4h3 M 241 G.s4h3.14
Hydrophobic TM6 L 390 6x45 G.H5 L 354 G.H5.25
Hydrophobic TM3 L 289 3x58 G.H5 I 345 G.H5.16
Van-der-waals TM3 L 289 3x58 G.H5 I 345 G.H5.16
Ionic TM5 K 368 5x64 G.H5 D 342 G.H5.13
Polar TM5 K 368 5x64 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 368 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 368 5x64 G.H5 D 342 G.H5.13
Hydrophobic TM5 L 364 5x60 G.H5 I 345 G.H5.16
Hydrophobic TM3 P 291 3x60 G.H5 T 341 G.H5.12
Hydrophobic TM6 S 386 6x41 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 386 6x41 G.H5 L 354 G.H5.25
Hydrophobic ICL3 H 372 - G.H5 F 355 G.H5.26
Hydrophobic ICL2 V 293 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 V 293 - G.S3 L 195 G.S3.01
Hydrophobic TM6 V 389 6x44 G.H5 L 354 G.H5.25
Hydrophobic TM3 L 289 3x58 G.H5 L 349 G.H5.20
Polar ICL3 H 372 - G.H5 K 346 G.H5.17
Hydrophobic ICL3 H 372 - G.H5 K 346 G.H5.17
Van-der-waals ICL3 H 372 - G.H5 K 346 G.H5.17
Polar C-term T 543 - G.s4h3 E 237 G.s4h3.10
Hydrophobic TM5 L 369 5x65 G.H5 F 355 G.H5.26
Hydrophobic C-term M 544 - G.s4h3 D 238 G.s4h3.11
Van-der-waals C-term M 544 - G.s4h3 D 238 G.s4h3.11
Ionic ICL2 R 297 - G.HN E 28 G.HN.52
Polar ICL2 R 297 - G.HN E 28 G.HN.52
Hydrophobic ICL2 R 297 - G.HN E 28 G.HN.52
Van-der-waals ICL2 R 297 - G.HN E 28 G.HN.52
Hydrophobic C-term I 547 - G.H3 K 249 G.H3.07
Hydrophobic ICL2 R 297 - G.HN R 24 G.HN.48
Van-der-waals ICL2 R 297 - G.HN R 24 G.HN.48
Ionic ICL3 H 372 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 H 372 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 H 372 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 H 372 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 K 368 5x64 G.H5 F 355 G.H5.26
Van-der-waals TM3 P 291 3x60 G.S3 L 195 G.S3.01
Hydrophobic C-term M 544 - G.s4h3 L 235 G.s4h3.08
Van-der-waals C-term M 544 - G.s4h3 L 235 G.s4h3.08
Hydrophobic ICL2 V 293 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 293 - G.hns1 R 32 G.hns1.03
Polar TM3 L 288 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 288 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 288 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 285 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 361 5x57 G.H5 L 354 G.H5.25
Hydrophobic TM5 K 368 5x64 G.H5 I 345 G.H5.16
Polar TM2 R 210 2x46 G.H5 D 351 G.H5.22
Van-der-waals TM2 R 210 2x46 G.H5 D 351 G.H5.22
Polar TM6 R 382 6x37 G.H5 F 355 G.H5.26
Aromatic TM6 R 382 6x37 G.H5 F 355 G.H5.26
Hydrophobic TM6 R 382 6x37 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 382 6x37 G.H5 F 355 G.H5.26
Hydrophobic TM3 L 285 3x54 G.H5 C 352 G.H5.23
Van-der-waals TM3 L 285 3x54 G.H5 C 352 G.H5.23
Hydrophobic TM3 P 291 3x60 G.H5 F 337 G.H5.08