Gi1 -
GnRH1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | S | 254 | 6x22 | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | TM6 | S | 254 | 6x22 | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | A | 142 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 142 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | TM2 | R | 75 | 2x38 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | R | 75 | 2x38 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | R | 75 | 2x38 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | A | 142 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 142 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | R | 262 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | L | 251 | - | G.H5 | A | 338 | G.H5.10 |
Van-der-waals | ICL3 | L | 251 | - | G.H5 | A | 338 | G.H5.10 |
Polar | ICL2 | P | 146 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 146 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | K | 150 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL3 | L | 251 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | L | 251 | - | G.S6 | Y | 320 | G.S6.02 |
Ionic | TM6 | K | 255 | 6x23 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM6 | K | 255 | 6x23 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | K | 255 | 6x23 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 255 | 6x23 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | I | 258 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | I | 258 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | A | 261 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | L | 251 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | ICL3 | L | 251 | - | G.S6 | H | 322 | G.S6.04 |
Ionic | TM4 | K | 154 | 4x40 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | K | 154 | 4x40 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | K | 154 | 4x40 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | K | 154 | 4x40 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | A | 261 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | K | 255 | 6x23 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 146 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM6 | Q | 253 | 6x21 | G.S6 | I | 319 | G.S6.01 |
Polar | TM2 | M | 76 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | M | 76 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | M | 76 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Polar | TM3 | D | 138 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | D | 138 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Ionic | ICL1 | K | 71 | 12x48 | G.h3s5 | D | 261 | G.h3s5.02 |
Polar | ICL1 | K | 71 | 12x48 | G.h3s5 | D | 261 | G.h3s5.02 |
Van-der-waals | ICL1 | K | 71 | 12x48 | G.h3s5 | D | 261 | G.h3s5.02 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | ICL3 | N | 252 | - | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | ICL3 | N | 252 | - | G.S6 | T | 321 | G.S6.03 |
Van-der-waals | ICL3 | N | 252 | - | G.S6 | T | 321 | G.S6.03 |
Polar | TM6 | N | 257 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | I | 258 | 6x26 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | A | 261 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | A | 261 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL3 | L | 249 | - | G.H5 | Q | 333 | G.H5.05 |
Van-der-waals | ICL3 | L | 249 | - | G.H5 | Q | 333 | G.H5.05 |
Hydrophobic | TM6 | T | 265 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 265 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | TM2 | R | 75 | 2x38 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM6 | I | 258 | 6x26 | G.H5 | F | 354 | G.H5.26 |
Polar | TM7 | Y | 323 | 7x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | K | 264 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 254 | 6x22 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM2 | M | 76 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | K | 255 | 6x23 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 255 | 6x23 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL1 | S | 74 | 12x51 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL1 | S | 74 | 12x51 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM6 | Q | 253 | 6x21 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM6 | Q | 253 | 6x21 | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL2 | K | 150 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | K | 150 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 150 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM6 | Q | 253 | 6x21 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 253 | 6x21 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | N | 257 | 6x25 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | N | 257 | 6x25 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM2 | M | 76 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | M | 76 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | TM7 | S | 327 | 7x57 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 146 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | L | 149 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | N | 252 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | N | 252 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | M | 268 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 268 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | K | 150 | - | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | K | 150 | - | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL3 | L | 251 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | L | 251 | - | G.H5 | D | 337 | G.H5.09 |
Polar | ICL2 | S | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | S | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | S | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | L | 249 | - | G.H5 | K | 330 | G.H5.02 |
Hydrophobic | TM6 | I | 258 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | I | 258 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL2 | K | 150 | - | G.S1 | V | 34 | G.S1.02 |
Polar | ICL3 | N | 252 | - | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | TM6 | N | 256 | 6x24 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 262 | 6x30 | G.H5 | I | 344 | G.H5.16 |
Polar | TM4 | N | 152 | 4x38 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | L | 249 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | L | 249 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | ICL2 | K | 150 | - | G.H5 | I | 343 | G.H5.15 |
Polar | TM6 | N | 257 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | N | 257 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM6 | Q | 253 | 6x21 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | Q | 253 | 6x21 | G.H5 | D | 341 | G.H5.13 |