Gi1 - GnRH1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 261 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 139 3x50 G.H5 L 353 G.H5.25
Polar TM6 Q 253 6x21 G.H5 D 341 G.H5.13
Van-der-waals TM6 Q 253 6x21 G.H5 D 341 G.H5.13
Polar TM6 N 257 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 N 257 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 I 258 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 I 258 6x26 G.H5 K 345 G.H5.17
Hydrophobic ICL2 L 149 34x53 G.H5 N 347 G.H5.19
Polar TM2 M 76 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 M 76 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 M 76 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 147 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 L 147 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM3 A 142 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 C 351 G.H5.23
Ionic ICL1 K 71 12x48 G.h3s5 D 261 G.h3s5.02
Polar ICL1 K 71 12x48 G.h3s5 D 261 G.h3s5.02
Van-der-waals ICL1 K 71 12x48 G.h3s5 D 261 G.h3s5.02
Hydrophobic TM6 K 255 6x23 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 I 258 6x26 G.H5 F 354 G.H5.26
Van-der-waals ICL2 K 150 - G.hns1 A 31 G.hns1.02
Ionic TM4 K 154 4x40 G.HN E 28 G.HN.52
Polar TM4 K 154 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 K 154 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 K 154 4x40 G.HN E 28 G.HN.52
Hydrophobic ICL2 L 147 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 147 34x51 G.S3 L 194 G.S3.01
Polar ICL2 K 150 - G.S1 E 33 G.S1.01
Van-der-waals ICL2 K 150 - G.S1 E 33 G.S1.01
Hydrophobic TM6 A 261 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 261 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 146 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 146 34x50 G.H5 I 344 G.H5.16
Polar TM2 R 75 2x38 G.H5 D 350 G.H5.22
Hydrophobic TM6 M 268 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 268 6x36 G.H5 L 353 G.H5.25
Polar TM7 S 327 7x57 G.H5 G 352 G.H5.24
Hydrophobic TM6 A 261 6x29 G.H5 L 353 G.H5.25
Hydrophobic ICL3 N 252 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 N 252 - G.S6 Y 320 G.S6.02
Polar TM3 D 138 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 138 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 265 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 265 6x33 G.H5 L 353 G.H5.25
Polar ICL2 S 151 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 S 151 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 S 151 - G.hns1 R 32 G.hns1.03
Polar TM7 Y 323 7x53 G.H5 C 351 G.H5.23
Van-der-waals TM6 S 254 6x22 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 251 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 L 251 - G.S6 H 322 G.S6.04
Hydrophobic TM6 Q 253 6x21 G.S6 Y 320 G.S6.02
Van-der-waals TM6 Q 253 6x21 G.S6 Y 320 G.S6.02
Polar TM6 N 257 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 M 76 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 M 76 2x39 G.H5 C 351 G.H5.23
Polar TM4 N 152 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 R 262 6x30 G.H5 I 344 G.H5.16
Polar TM2 R 75 2x38 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 75 2x38 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 75 2x38 G.H5 C 351 G.H5.23
Polar ICL2 K 150 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 150 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 150 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 251 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 L 251 - G.H5 A 338 G.H5.10
Hydrophobic TM6 Q 253 6x21 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 253 6x21 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 K 264 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL1 S 74 12x51 G.H5 D 350 G.H5.22
Van-der-waals ICL1 S 74 12x51 G.H5 D 350 G.H5.22
Hydrophobic TM6 I 258 6x26 G.H5 I 344 G.H5.16
Van-der-waals TM6 Q 253 6x21 G.S6 I 319 G.S6.01
Hydrophobic TM6 N 257 6x25 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 257 6x25 G.H5 F 354 G.H5.26
Hydrophobic TM2 M 76 2x39 G.H5 G 352 G.H5.24
Polar TM3 A 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 N 256 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 251 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 251 - G.H5 D 337 G.H5.09
Ionic TM6 K 255 6x23 G.h4s6 D 315 G.h4s6.09
Polar TM6 K 255 6x23 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 K 255 6x23 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 255 6x23 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 K 150 - G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 249 - G.H5 K 330 G.H5.02
Polar TM6 S 254 6x22 G.S6 I 319 G.S6.01
Van-der-waals TM6 S 254 6x22 G.S6 I 319 G.S6.01
Hydrophobic TM6 K 255 6x23 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 255 6x23 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 251 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 L 251 - G.S6 Y 320 G.S6.02
Polar ICL3 N 252 - G.H4 Q 304 G.H4.12
Polar ICL2 P 146 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 146 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 249 - G.H5 Q 333 G.H5.05
Van-der-waals ICL3 L 249 - G.H5 Q 333 G.H5.05
Hydrophobic TM6 I 258 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 I 258 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 249 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 L 249 - G.H5 F 334 G.H5.06
Polar ICL3 N 252 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 N 252 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 N 252 - G.S6 T 321 G.S6.03
Van-der-waals ICL2 K 150 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 P 146 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 R 262 6x30 G.H5 L 348 G.H5.20