GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 70.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 27.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | W | 421 | 5x56 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM5 | W | 421 | 5x56 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM5 | W | 421 | 5x56 | G.H5 | E | 379 | G.H5.24 |
Polar | C-term | D | 551 | - | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | C-term | D | 551 | - | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | C-term | D | 551 | - | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | TM4 | I | 369 | 4x45 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM4 | I | 369 | 4x45 | G.H5 | L | 380 | G.H5.25 |
Ionic | C-term | E | 561 | - | G.S1 | R | 44 | G.S1.03 |
Polar | C-term | E | 561 | - | G.S1 | R | 44 | G.S1.03 |
Hydrophobic | C-term | E | 561 | - | G.S1 | R | 44 | G.S1.03 |
Van-der-waals | C-term | E | 561 | - | G.S1 | R | 44 | G.S1.03 |
Polar | TM3 | G | 354 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | M | 566 | - | G.H2 | Q | 223 | G.H2.09 |
Polar | C-term | Q | 559 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | C-term | Q | 559 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | C-term | Q | 559 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | C-term | L | 557 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | C-term | L | 557 | - | G.hns1 | Y | 39 | G.hns1.01 |
Polar | C-term | D | 551 | - | G.HN | K | 34 | G.HN.49 |
Hydrophobic | TM5 | S | 422 | 5x57 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM5 | S | 422 | 5x57 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM6 | T | 483 | 6x25 | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | TM6 | T | 483 | 6x25 | G.h2s4 | N | 226 | G.h2s4.02 |
Van-der-waals | TM6 | T | 483 | 6x25 | G.h2s4 | N | 226 | G.h2s4.02 |
Polar | TM4 | S | 363 | 4x39 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM4 | S | 363 | 4x39 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM4 | S | 363 | 4x39 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | T | 353 | 3x52 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | T | 353 | 3x52 | G.H5 | H | 374 | G.H5.19 |
Ionic | C-term | E | 560 | - | G.HN | R | 36 | G.HN.51 |
Polar | C-term | E | 560 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | C-term | E | 560 | - | G.HN | R | 36 | G.HN.51 |
Van-der-waals | C-term | E | 560 | - | G.HN | R | 36 | G.HN.51 |
Polar | C-term | S | 558 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | C-term | S | 558 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | C-term | S | 558 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | ICL2 | I | 361 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | I | 361 | - | G.H5 | Q | 371 | G.H5.16 |
Polar | C-term | L | 557 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | C-term | N | 552 | - | G.HN | L | 37 | G.HN.52 |
Polar | TM4 | K | 365 | 4x41 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM4 | K | 365 | 4x41 | G.H5 | E | 379 | G.H5.24 |
Polar | TM3 | G | 352 | 3x51 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | G | 352 | 3x51 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | G | 352 | 3x51 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM4 | D | 366 | 4x42 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM4 | D | 366 | 4x42 | G.H5 | Y | 378 | G.H5.23 |
Polar | C-term | S | 550 | - | G.HN | K | 34 | G.HN.49 |
Hydrophobic | C-term | S | 550 | - | G.HN | K | 34 | G.HN.49 |
Van-der-waals | C-term | S | 550 | - | G.HN | K | 34 | G.HN.49 |
Hydrophobic | TM4 | D | 364 | 4x40 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM4 | D | 364 | 4x40 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | Q | 559 | - | G.HN | E | 35 | G.HN.50 |
Van-der-waals | C-term | Q | 559 | - | G.HN | E | 35 | G.HN.50 |
Hydrophobic | ICL2 | I | 358 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | I | 358 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | M | 579 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | M | 579 | - | H.HA | E | 74 | H.HA.03 |
Polar | TM3 | T | 353 | 3x52 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | T | 353 | 3x52 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | T | 353 | 3x52 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL2 | K | 359 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | K | 359 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | K | 359 | - | G.H5 | I | 370 | G.H5.15 |
Polar | TM6 | Y | 498 | 6x40 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM6 | Y | 498 | 6x40 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM6 | Y | 498 | 6x40 | G.H5 | Y | 378 | G.H5.23 |
Polar | C-term | Q | 559 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | C-term | Q | 559 | - | G.HN | R | 36 | G.HN.51 |
Van-der-waals | C-term | Q | 559 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | C-term | M | 576 | - | H.HA | K | 78 | H.HA.07 |
Polar | C-term | P | 553 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | C-term | P | 553 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | M | 576 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | M | 576 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | M | 576 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | M | 576 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | ICL3 | L | 467 | - | G.H2 | R | 219 | G.H2.05 |
Aromatic | TM6 | F | 494 | 6x36 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM6 | F | 494 | 6x36 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM4 | K | 365 | 4x41 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM4 | K | 365 | 4x41 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | M | 576 | - | G.h1ha | F | 70 | G.h1ha.04 |
Hydrophobic | ICL2 | I | 358 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | A | 549 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | C-term | A | 549 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | C-term | L | 557 | - | G.S1 | T | 42 | G.S1.01 |
Van-der-waals | C-term | L | 557 | - | G.S1 | T | 42 | G.S1.01 |
Hydrophobic | C-term | M | 579 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | M | 579 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | ICL2 | I | 361 | - | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | I | 361 | - | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM3 | G | 354 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | L | 426 | 5x61 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM5 | L | 426 | 5x61 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM6 | F | 494 | 6x36 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM6 | F | 494 | 6x36 | G.H5 | Y | 378 | G.H5.23 |
Polar | C-term | Q | 556 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | Q | 556 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | C-term | Q | 556 | - | G.hns1 | K | 40 | G.hns1.02 |
Polar | TM6 | N | 487 | 6x29 | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | TM6 | N | 487 | 6x29 | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | C-term | D | 551 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | C-term | E | 561 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | C-term | E | 561 | - | G.hns1 | Y | 39 | G.hns1.01 |
Polar | C-term | V | 575 | - | H.HA | Q | 77 | H.HA.06 |
Hydrophobic | C-term | V | 575 | - | H.HA | Q | 77 | H.HA.06 |
Van-der-waals | C-term | V | 575 | - | H.HA | Q | 77 | H.HA.06 |
Polar | C-term | Q | 556 | - | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | C-term | Q | 556 | - | G.HN | Q | 33 | G.HN.48 |
Polar | TM4 | K | 365 | 4x41 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM4 | K | 365 | 4x41 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM4 | K | 365 | 4x41 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | Q | 556 | - | G.HN | R | 36 | G.HN.51 |
Van-der-waals | C-term | Q | 556 | - | G.HN | R | 36 | G.HN.51 |
Polar | C-term | S | 558 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | C-term | S | 558 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | C-term | S | 558 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | TM5 | S | 422 | 5x57 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM5 | S | 422 | 5x57 | G.H5 | Q | 377 | G.H5.22 |
Ionic | TM5 | H | 425 | 5x60 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM5 | H | 425 | 5x60 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM5 | H | 425 | 5x60 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | T | 483 | 6x25 | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | TM4 | D | 366 | 4x42 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM4 | D | 366 | 4x42 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL1 | D | 290 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | C-term | Y | 554 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | C-term | Y | 554 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | L | 557 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Polar | C-term | Q | 559 | - | G.HN | L | 32 | G.HN.47 |
Hydrophobic | C-term | Q | 559 | - | G.HN | L | 32 | G.HN.47 |
Van-der-waals | C-term | Q | 559 | - | G.HN | L | 32 | G.HN.47 |
Hydrophobic | TM6 | I | 486 | 6x28 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | TM6 | I | 486 | 6x28 | G.HN | R | 36 | G.HN.51 |
Polar | ICL2 | K | 359 | - | G.H5 | H | 374 | G.H5.19 |
Aromatic | ICL2 | K | 359 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | K | 359 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | K | 359 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | K | 359 | - | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL3 | L | 467 | - | G.H2 | I | 222 | G.H2.08 |
Hydrophobic | C-term | L | 555 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | C-term | L | 555 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | C-term | L | 557 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | C-term | L | 557 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | TM4 | K | 365 | 4x41 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | S | 550 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | C-term | S | 550 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | C-term | S | 550 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | C-term | S | 550 | - | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | C-term | S | 550 | - | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | C-term | Q | 556 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | C-term | Q | 556 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL2 | I | 358 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM6 | K | 490 | 6x32 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | TM6 | K | 490 | 6x32 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM4 | S | 363 | 4x39 | G.H5 | H | 374 | G.H5.19 |
Polar | C-term | L | 555 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | L | 555 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | C-term | L | 555 | - | G.hns1 | K | 40 | G.hns1.02 |