GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 70.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 28.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | I | 358 | - | G.H5 | Q | 390 | G.H5.22 |
Polar | C-term | Q | 556 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | C-term | Q | 556 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | Q | 556 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | Q | 559 | - | G.h4s6 | G | 353 | G.h4s6.09 |
Polar | TM4 | K | 367 | 4x43 | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | TM4 | K | 367 | 4x43 | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | ICL2 | I | 361 | - | G.H3 | W | 281 | G.H3.17 |
Polar | C-term | E | 562 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | C-term | E | 562 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Van-der-waals | C-term | E | 562 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | TM5 | A | 429 | 5x64 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | A | 429 | 5x64 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | S | 558 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Hydrophobic | C-term | S | 558 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Van-der-waals | C-term | S | 558 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Hydrophobic | TM6 | K | 490 | 6x32 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | TM6 | K | 490 | 6x32 | G.H5 | R | 389 | G.H5.21 |
Polar | C-term | S | 558 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | C-term | S | 558 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Van-der-waals | C-term | S | 558 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | C-term | E | 560 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | ICL2 | I | 358 | - | G.H5 | R | 389 | G.H5.21 |
Polar | C-term | L | 557 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Hydrophobic | C-term | L | 557 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Van-der-waals | C-term | L | 557 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Polar | ICL1 | D | 290 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | ICL1 | D | 290 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Ionic | TM4 | D | 366 | 4x42 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM4 | D | 366 | 4x42 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM4 | D | 366 | 4x42 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | A | 484 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Polar | C-term | E | 562 | - | G.H3 | N | 278 | G.H3.14 |
Hydrophobic | C-term | E | 562 | - | G.H3 | N | 278 | G.H3.14 |
Van-der-waals | C-term | E | 562 | - | G.H3 | N | 278 | G.H3.14 |
Hydrophobic | TM6 | I | 486 | 6x28 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | I | 486 | 6x28 | G.h4s6 | Y | 358 | G.h4s6.20 |
Ionic | C-term | E | 562 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | C-term | E | 562 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | C-term | E | 562 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | E | 562 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | TM5 | S | 422 | 5x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM5 | S | 422 | 5x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | H | 425 | 5x60 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | H | 425 | 5x60 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | N | 487 | 6x29 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM6 | N | 487 | 6x29 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | TM6 | N | 487 | 6x29 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | C-term | E | 562 | - | G.H3 | W | 277 | G.H3.13 |
Polar | ICL2 | K | 359 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | ICL2 | K | 359 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | ICL2 | K | 359 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Polar | C-term | Q | 556 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | T | 483 | 6x25 | G.S6 | Y | 360 | G.S6.02 |
Polar | ICL2 | K | 359 | - | G.H5 | Y | 391 | G.H5.23 |
Aromatic | ICL2 | K | 359 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | K | 359 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | K | 359 | - | G.H5 | Y | 391 | G.H5.23 |
Polar | C-term | Q | 559 | - | G.h4s6 | A | 351 | G.h4s6.04 |
Hydrophobic | ICL2 | F | 357 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | ICL2 | F | 357 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Polar | C-term | Q | 559 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | C-term | Q | 559 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Van-der-waals | C-term | Q | 559 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | ICL2 | I | 361 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Hydrophobic | ICL2 | H | 360 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | ICL2 | H | 360 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Aromatic | TM2 | F | 292 | 2x36 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM2 | F | 292 | 2x36 | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | TM2 | F | 292 | 2x36 | G.h4s6 | R | 356 | G.h4s6.12 |
Ionic | C-term | E | 565 | - | G.H3 | K | 274 | G.H3.10 |
Polar | C-term | E | 565 | - | G.H3 | K | 274 | G.H3.10 |
Hydrophobic | C-term | E | 565 | - | G.H3 | K | 274 | G.H3.10 |
Van-der-waals | C-term | E | 565 | - | G.H3 | K | 274 | G.H3.10 |
Polar | C-term | Q | 556 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | C-term | Q | 556 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Van-der-waals | C-term | Q | 556 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | TM3 | G | 352 | 3x51 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM3 | G | 352 | 3x51 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL2 | H | 360 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | ICL2 | H | 360 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | ICL2 | H | 360 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | M | 566 | - | G.H3 | N | 278 | G.H3.14 |
Van-der-waals | C-term | M | 566 | - | G.H3 | N | 278 | G.H3.14 |
Hydrophobic | TM6 | N | 487 | 6x29 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM4 | S | 363 | 4x39 | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | TM4 | S | 363 | 4x39 | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | C-term | E | 560 | - | G.h4s6 | A | 351 | G.h4s6.04 |
Hydrophobic | C-term | E | 560 | - | G.h4s6 | A | 351 | G.h4s6.04 |
Van-der-waals | C-term | E | 560 | - | G.h4s6 | A | 351 | G.h4s6.04 |
Ionic | C-term | E | 561 | - | G.H3 | K | 274 | G.H3.10 |
Polar | C-term | E | 561 | - | G.H3 | K | 274 | G.H3.10 |
Hydrophobic | C-term | E | 561 | - | G.H3 | K | 274 | G.H3.10 |
Van-der-waals | C-term | E | 561 | - | G.H3 | K | 274 | G.H3.10 |
Hydrophobic | TM4 | K | 365 | 4x41 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | K | 365 | 4x41 | G.HN | Q | 35 | G.HN.52 |
Polar | C-term | L | 557 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | C-term | L | 557 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | C-term | L | 557 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | TM5 | S | 422 | 5x57 | G.H5 | E | 392 | G.H5.24 |
Polar | TM4 | D | 364 | 4x40 | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | TM4 | D | 364 | 4x40 | G.h2s4 | N | 239 | G.h2s4.02 |
Ionic | TM5 | D | 433 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Polar | TM5 | D | 433 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | D | 433 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | D | 433 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Polar | TM6 | K | 490 | 6x32 | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | TM6 | K | 490 | 6x32 | G.h4s6 | G | 355 | G.h4s6.11 |
Polar | ICL1 | V | 291 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | ICL1 | V | 291 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM4 | S | 363 | 4x39 | G.H5 | Y | 391 | G.H5.23 |
Ionic | C-term | E | 562 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Polar | C-term | E | 562 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Ionic | ICL2 | K | 359 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | ICL2 | K | 359 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | ICL2 | K | 359 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | TM4 | K | 365 | 4x41 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM4 | K | 365 | 4x41 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | L | 491 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | L | 491 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | K | 359 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | K | 359 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL2 | K | 359 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM5 | H | 425 | 5x60 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | H | 425 | 5x60 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | L | 426 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | L | 426 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | M | 566 | - | G.H3 | N | 279 | G.H3.15 |
Hydrophobic | TM5 | L | 426 | 5x61 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM5 | L | 426 | 5x61 | G.H5 | E | 392 | G.H5.24 |
Polar | TM5 | S | 422 | 5x57 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM3 | T | 353 | 3x52 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | T | 353 | 3x52 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM3 | T | 353 | 3x52 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | I | 361 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | ICL2 | I | 361 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Ionic | TM6 | R | 479 | 6x21 | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM6 | R | 479 | 6x21 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM6 | R | 479 | 6x21 | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | TM6 | R | 479 | 6x21 | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM6 | Y | 498 | 6x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | Y | 498 | 6x40 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | Y | 498 | 6x40 | G.H5 | E | 392 | G.H5.24 |
Polar | TM4 | K | 365 | 4x41 | G.HN | K | 34 | G.HN.51 |
Hydrophobic | TM4 | K | 365 | 4x41 | G.HN | K | 34 | G.HN.51 |
Van-der-waals | TM4 | K | 365 | 4x41 | G.HN | K | 34 | G.HN.51 |
Hydrophobic | TM5 | A | 429 | 5x64 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM5 | S | 430 | 5x65 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | S | 558 | - | G.h4s6 | G | 353 | G.h4s6.09 |
Van-der-waals | C-term | S | 558 | - | G.h4s6 | G | 353 | G.h4s6.09 |
Polar | ICL2 | H | 360 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | ICL2 | H | 360 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | ICL2 | H | 360 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | TM5 | W | 421 | 5x56 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM5 | W | 421 | 5x56 | G.HN | Q | 35 | G.HN.52 |
Polar | ICL2 | I | 358 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | ICL2 | I | 358 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | ICL2 | I | 358 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | TM5 | S | 422 | 5x57 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | S | 422 | 5x57 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | S | 558 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | C-term | S | 558 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Van-der-waals | C-term | S | 558 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | C-term | L | 557 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | L | 557 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | C-term | E | 561 | - | G.h4s6 | I | 348 | G.h4s6.01 |
Hydrophobic | C-term | E | 561 | - | G.h4s6 | I | 348 | G.h4s6.01 |
Van-der-waals | C-term | E | 561 | - | G.h4s6 | I | 348 | G.h4s6.01 |
Polar | TM6 | K | 490 | 6x32 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM6 | K | 490 | 6x32 | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | TM6 | K | 490 | 6x32 | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM4 | D | 364 | 4x40 | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | TM4 | D | 364 | 4x40 | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | C-term | E | 561 | - | G.h4s6 | A | 351 | G.h4s6.04 |
Hydrophobic | C-term | E | 561 | - | G.h4s6 | A | 351 | G.h4s6.04 |
Polar | TM6 | L | 491 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | L | 491 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | L | 491 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | N | 487 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Polar | C-term | L | 557 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | C-term | L | 557 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | L | 557 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | C-term | Q | 559 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | C-term | Q | 559 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Van-der-waals | C-term | Q | 559 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | ICL2 | F | 357 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | ICL2 | F | 357 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM4 | K | 368 | 4x44 | G.HN | K | 34 | G.HN.51 |
Polar | TM6 | I | 486 | 6x28 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | TM6 | I | 486 | 6x28 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | C-term | E | 561 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Van-der-waals | C-term | E | 561 | - | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | C-term | Q | 556 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | C-term | Q | 556 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | TM6 | F | 494 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | F | 494 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | E | 561 | - | G.H3 | N | 278 | G.H3.14 |
Hydrophobic | C-term | E | 561 | - | G.H3 | N | 278 | G.H3.14 |
Van-der-waals | C-term | E | 561 | - | G.H3 | N | 278 | G.H3.14 |
Polar | TM3 | G | 354 | 3x53 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM3 | G | 354 | 3x53 | G.H5 | E | 392 | G.H5.24 |
Ionic | C-term | D | 563 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | C-term | D | 563 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | D | 563 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | ICL2 | H | 360 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | ICL2 | H | 360 | - | G.H3 | W | 281 | G.H3.17 |
Polar | C-term | S | 558 | - | G.H3 | W | 277 | G.H3.13 |
Hydrophobic | C-term | S | 558 | - | G.H3 | W | 277 | G.H3.13 |
Van-der-waals | C-term | S | 558 | - | G.H3 | W | 277 | G.H3.13 |
Polar | C-term | L | 557 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | C-term | L | 557 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Van-der-waals | C-term | L | 557 | - | G.h4s6 | D | 354 | G.h4s6.10 |