GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
          (Gα residues)
          and an outer concentric circle (GPCR residues) depicting the interface interactions.
          Different interaction types are shown with different line types (aromatic - solid,
          hydrophobic - dashed,
          ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
          The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
        
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
        
        
        GPCR
        Interaction cut-off: strict (stick), loose (line)
      
| Interaction type | GPCR Segment | AA | Number | Generic number | Gα segment | AA | Number | Generic number | 
|---|---|---|---|---|---|---|---|---|
| Interaction type | GPCR Segment | AA | Number | Generic number | Gα segment | AA | Number | Generic number | 
|---|---|---|---|---|---|---|---|---|
| Hydrophobic | ICL2 | L | 148 | 34x51 | G.S1 | L | 36 | G.S1.02 | 
| Hydrophobic | TM6 | K | 239 | 6x32 | G.H5 | L | 354 | G.H5.25 | 
| Hydrophobic | TM3 | A | 143 | 3x53 | G.H5 | F | 352 | G.H5.23 | 
| Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | K | 341 | G.H5.12 | 
| Hydrophobic | H8 | T | 312 | 8x47 | G.H5 | N | 353 | G.H5.24 | 
| Hydrophobic | ICL3 | L | 232 | - | G.H5 | L | 349 | G.H5.20 | 
| Hydrophobic | ICL2 | A | 147 | 34x50 | G.H5 | L | 345 | G.H5.16 | 
| Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | L | 354 | G.H5.25 | 
| Hydrophobic | TM6 | V | 240 | 6x33 | G.H5 | L | 349 | G.H5.20 | 
| Hydrophobic | TM6 | V | 240 | 6x33 | G.H5 | V | 355 | G.H5.26 | 
| Hydrophobic | TM6 | V | 240 | 6x33 | G.H5 | L | 354 | G.H5.25 | 
| Hydrophobic | TM5 | I | 226 | 5x65 | G.H5 | L | 349 | G.H5.20 | 
| Hydrophobic | ICL3 | M | 230 | - | G.S6 | Y | 321 | G.S6.02 | 
| Hydrophobic | TM3 | A | 143 | 3x53 | G.H5 | N | 348 | G.H5.19 | 
| Hydrophobic | H8 | H | 314 | 8x49 | G.H5 | N | 353 | G.H5.24 | 
| Hydrophobic | ICL2 | E | 149 | 34x52 | G.S3 | I | 195 | G.S3.01 | 
| Hydrophobic | TM2 | N | 75 | 2x37 | G.H5 | E | 351 | G.H5.22 | 
| Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | I | 344 | G.H5.15 | 
| Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 345 | G.H5.16 | 
| Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 349 | G.H5.20 | 
| Hydrophobic | ICL2 | L | 148 | 34x51 | G.S3 | F | 197 | G.S3.03 | 
| Hydrophobic | ICL2 | R | 154 | 34x57 | G.H5 | F | 352 | G.H5.23 | 
| Hydrophobic | ICL2 | R | 151 | 34x54 | G.hns1 | R | 33 | G.hns1.02 | 
| Hydrophobic | TM3 | V | 145 | 3x55 | G.H5 | K | 341 | G.H5.12 | 
| Hydrophobic | ICL3 | L | 232 | - | G.H5 | L | 345 | G.H5.16 | 
| Hydrophobic | ICL3 | L | 232 | - | G.H5 | V | 355 | G.H5.26 | 
| Hydrophobic | ICL3 | G | 231 | - | G.h4s6 | V | 319 | G.h4s6.20 | 
| Hydrophobic | TM6 | K | 239 | 6x32 | G.H5 | V | 355 | G.H5.26 | 
| Hydrophobic | ICL2 | R | 151 | 34x54 | G.S1 | L | 36 | G.S1.02 | 
| Hydrophobic | TM5 | S | 229 | 5x68 | G.H5 | L | 345 | G.H5.16 | 
| Hydrophobic | ICL2 | R | 151 | 34x54 | G.H5 | I | 344 | G.H5.15 | 
| Hydrophobic | TM2 | L | 77 | 2x39 | G.H5 | F | 352 | G.H5.23 | 
| Hydrophobic | ICL2 | A | 147 | 34x50 | G.H5 | I | 344 | G.H5.15 | 
| Hydrophobic | ICL2 | E | 149 | 34x52 | G.H5 | K | 341 | G.H5.12 | 
| Hydrophobic | ICL2 | L | 148 | 34x51 | G.S3 | I | 195 | G.S3.01 | 
| Hydrophobic | ICL2 | G | 152 | 34x55 | G.hns1 | R | 33 | G.hns1.02 | 
| Hydrophobic | ICL3 | G | 231 | - | G.S6 | Y | 321 | G.S6.02 | 
| Hydrophobic | ICL3 | L | 232 | - | G.H5 | Q | 346 | G.H5.17 | 
| Hydrophobic | TM6 | S | 243 | 6x36 | G.H5 | L | 354 | G.H5.25 | 
| Hydrophobic | TM5 | S | 229 | 5x68 | G.H5 | D | 342 | G.H5.13 | 
| Hydrophobic | ICL2 | G | 152 | 34x55 | G.hns1 | R | 34 | G.hns1.03 | 
| Hydrophobic | TM6 | Q | 236 | 6x29 | G.H5 | V | 355 | G.H5.26 | 
| Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | V | 340 | G.H5.11 | 
| Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | F | 337 | G.H5.08 | 
| Hydrophobic | ICL3 | G | 231 | - | G.H5 | Q | 346 | G.H5.17 | 
| Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | F | 352 | G.H5.23 | 
| Hydrophobic | ICL3 | M | 230 | - | G.H5 | F | 335 | G.H5.06 | 
| Ionic | ICL2 | R | 154 | 34x57 | G.H5 | E | 351 | G.H5.22 | 
| Ionic | ICL2 | E | 149 | 34x52 | G.H5 | K | 341 | G.H5.12 | 
| Polar | H8 | T | 312 | 8x47 | G.H5 | N | 353 | G.H5.24 | 
| Polar | ICL2 | R | 154 | 34x57 | G.H5 | E | 351 | G.H5.22 | 
| Polar | TM3 | A | 143 | 3x53 | G.H5 | N | 348 | G.H5.19 | 
| Polar | TM2 | N | 75 | 2x37 | G.H5 | E | 351 | G.H5.22 | 
| Polar | ICL2 | R | 151 | 34x54 | G.hns1 | R | 33 | G.hns1.02 | 
| Polar | ICL3 | M | 230 | - | G.H5 | D | 342 | G.H5.13 | 
| Polar | TM3 | V | 145 | 3x55 | G.H5 | K | 341 | G.H5.12 | 
| Polar | ICL2 | R | 151 | 34x54 | G.S1 | E | 35 | G.S1.01 | 
| Polar | TM6 | K | 239 | 6x32 | G.H5 | V | 355 | G.H5.26 | 
| Polar | ICL2 | E | 149 | 34x52 | G.H5 | K | 341 | G.H5.12 | 
| Polar | ICL2 | G | 152 | 34x55 | G.hns1 | R | 33 | G.hns1.02 | 
| Polar | ICL3 | G | 231 | - | G.H5 | D | 342 | G.H5.13 | 
| Polar | TM5 | S | 229 | 5x68 | G.H5 | D | 342 | G.H5.13 | 
| Polar | ICL2 | R | 151 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 | 
| Polar | TM3 | R | 140 | 3x50 | G.H5 | F | 352 | G.H5.23 | 
| Van-der-waals | ICL2 | L | 148 | 34x51 | G.S1 | L | 36 | G.S1.02 | 
| Van-der-waals | TM6 | K | 239 | 6x32 | G.H5 | L | 354 | G.H5.25 | 
| Van-der-waals | TM3 | A | 143 | 3x53 | G.H5 | F | 352 | G.H5.23 | 
| Van-der-waals | ICL2 | L | 148 | 34x51 | G.H5 | K | 341 | G.H5.12 | 
| Van-der-waals | H8 | T | 312 | 8x47 | G.H5 | N | 353 | G.H5.24 | 
| Van-der-waals | ICL2 | R | 154 | 34x57 | G.H5 | E | 351 | G.H5.22 | 
| Van-der-waals | ICL3 | L | 232 | - | G.H5 | L | 349 | G.H5.20 | 
| Van-der-waals | TM6 | V | 240 | 6x33 | G.H5 | V | 355 | G.H5.26 | 
| Van-der-waals | TM6 | V | 240 | 6x33 | G.H5 | L | 354 | G.H5.25 | 
| Van-der-waals | TM3 | A | 143 | 3x53 | G.H5 | N | 348 | G.H5.19 | 
| Van-der-waals | H8 | H | 314 | 8x49 | G.H5 | N | 353 | G.H5.24 | 
| Van-der-waals | TM2 | N | 75 | 2x37 | G.H5 | E | 351 | G.H5.22 | 
| Van-der-waals | ICL2 | L | 148 | 34x51 | G.H5 | I | 344 | G.H5.15 | 
| Van-der-waals | TM3 | V | 144 | 3x54 | G.H5 | L | 345 | G.H5.16 | 
| Van-der-waals | TM3 | V | 144 | 3x54 | G.H5 | L | 349 | G.H5.20 | 
| Van-der-waals | ICL2 | R | 154 | 34x57 | G.H5 | F | 352 | G.H5.23 | 
| Van-der-waals | ICL2 | R | 151 | 34x54 | G.hns1 | R | 33 | G.hns1.02 | 
| Van-der-waals | ICL3 | M | 230 | - | G.H5 | D | 342 | G.H5.13 | 
| Van-der-waals | TM3 | V | 145 | 3x55 | G.H5 | K | 341 | G.H5.12 | 
| Van-der-waals | ICL3 | G | 231 | - | G.h4s6 | V | 319 | G.h4s6.20 | 
| Van-der-waals | TM6 | K | 239 | 6x32 | G.H5 | V | 355 | G.H5.26 | 
| Van-der-waals | ICL2 | R | 151 | 34x54 | G.S1 | L | 36 | G.S1.02 | 
| Van-der-waals | TM2 | L | 77 | 2x39 | G.H5 | F | 352 | G.H5.23 | 
| Van-der-waals | ICL2 | A | 147 | 34x50 | G.H5 | I | 344 | G.H5.15 | 
| Van-der-waals | ICL2 | E | 149 | 34x52 | G.H5 | K | 341 | G.H5.12 | 
| Van-der-waals | ICL3 | G | 231 | - | G.H5 | D | 342 | G.H5.13 | 
| Van-der-waals | TM6 | S | 243 | 6x36 | G.H5 | L | 354 | G.H5.25 | 
| Van-der-waals | TM5 | S | 229 | 5x68 | G.H5 | D | 342 | G.H5.13 | 
| Van-der-waals | TM6 | Q | 236 | 6x29 | G.H5 | V | 355 | G.H5.26 | 
| Van-der-waals | ICL2 | L | 148 | 34x51 | G.H5 | F | 337 | G.H5.08 | 
| Van-der-waals | ICL2 | R | 151 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 | 
| Van-der-waals | ICL3 | G | 231 | - | G.H5 | Q | 346 | G.H5.17 | 
| Van-der-waals | TM3 | R | 140 | 3x50 | G.H5 | F | 352 | G.H5.23 |