GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 70.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | S | 325 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | T | 332 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | T | 332 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL3 | N | 315 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | TM6 | R | 322 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | R | 322 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Polar | TM3 | A | 212 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 212 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 212 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM6 | L | 321 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM6 | L | 321 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM5 | V | 311 | 5x72 | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | TM6 | S | 325 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | S | 325 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | P | 392 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | P | 392 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL2 | R | 218 | - | G.S1 | E | 39 | G.S1.01 |
Van-der-waals | ICL2 | R | 218 | - | G.S1 | E | 39 | G.S1.01 |
Ionic | ICL2 | K | 220 | - | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | K | 220 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | K | 220 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | K | 220 | - | G.H5 | E | 355 | G.H5.22 |
Polar | ICL3 | V | 314 | - | G.S6 | I | 324 | G.S6.01 |
Van-der-waals | ICL3 | V | 314 | - | G.S6 | I | 324 | G.S6.01 |
Hydrophobic | TM7 | R | 390 | 7x56 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM7 | R | 390 | 7x56 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | V | 311 | 5x72 | G.H5 | D | 346 | G.H5.13 |
Polar | ICL2 | K | 220 | - | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | K | 220 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | K | 220 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM6 | S | 325 | 6x29 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | R | 209 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | R | 209 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 318 | 6x22 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | A | 318 | 6x22 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | ICL3 | P | 313 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | P | 313 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Ionic | TM6 | R | 322 | 6x26 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | R | 322 | 6x26 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM6 | R | 322 | 6x26 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | R | 322 | 6x26 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | T | 329 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | T | 329 | 6x33 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | S | 307 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | S | 307 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL3 | V | 314 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | TM3 | R | 209 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL2 | R | 218 | - | G.hns1 | A | 36 | G.hns1.01 |
Van-der-waals | ICL2 | R | 218 | - | G.hns1 | A | 36 | G.hns1.01 |
Hydrophobic | ICL3 | Y | 317 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | ICL3 | Y | 317 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM6 | E | 326 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | E | 326 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Polar | TM6 | A | 318 | 6x22 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM6 | A | 318 | 6x22 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL3 | V | 314 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | V | 314 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL3 | V | 314 | - | G.H4 | V | 314 | G.H4.16 |
Polar | TM6 | E | 326 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | E | 326 | 6x30 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | H8 | N | 391 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | R | 328 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | R | 328 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | P | 217 | - | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 217 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL3 | P | 313 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | N | 315 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Polar | TM5 | S | 307 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | H8 | P | 392 | 8x48 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | P | 392 | 8x48 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | H8 | P | 392 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | P | 392 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Polar | ICL2 | R | 218 | - | G.h2s4 | T | 224 | G.h2s4.05 |
Hydrophobic | TM5 | R | 310 | 5x71 | G.H5 | A | 342 | G.H5.09 |
Polar | TM6 | R | 328 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | R | 328 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | R | 328 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | F | 469 | - | G.H2 | I | 217 | G.H2.08 |
Polar | TM3 | D | 208 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | D | 208 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | D | 208 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | T | 138 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | T | 138 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | F | 469 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | F | 469 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | TM3 | I | 213 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 213 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM3 | A | 212 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 212 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL2 | P | 217 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | P | 217 | - | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM5 | V | 311 | 5x72 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM5 | V | 311 | 5x72 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM5 | V | 311 | 5x72 | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | TM5 | V | 311 | 5x72 | G.H5 | A | 342 | G.H5.09 |
Ionic | ICL2 | E | 219 | - | G.hns1 | R | 38 | G.hns1.03 |
Polar | ICL2 | E | 219 | - | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | E | 219 | - | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | C-term | F | 469 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | F | 469 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | ICL2 | K | 220 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | P | 217 | - | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | P | 217 | - | G.S3 | I | 199 | G.S3.01 |
Polar | C-term | Y | 406 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | Y | 406 | - | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | C-term | Y | 406 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | R | 218 | - | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | R | 218 | - | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | TM6 | T | 329 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 213 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Polar | TM6 | S | 325 | 6x29 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | S | 325 | 6x29 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL2 | K | 220 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | R | 218 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | R | 218 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL3 | N | 315 | - | G.h4s6 | K | 322 | G.h4s6.13 |
Hydrophobic | TM5 | V | 311 | 5x72 | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | TM5 | V | 311 | 5x72 | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | TM6 | T | 329 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | T | 329 | 6x33 | G.H5 | L | 353 | G.H5.20 |