Ggust - GPR135 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 71.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic C-term F 469 - G.H3 H 256 G.H3.15
Hydrophobic C-term F 469 - G.H3 H 256 G.H3.15
Hydrophobic ICL2 P 217 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 217 - G.H5 I 343 G.H5.15
Ionic ICL2 E 219 - G.hns1 R 32 G.hns1.03
Polar ICL2 E 219 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 E 219 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 219 - G.hns1 R 32 G.hns1.03
Polar TM5 S 307 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 307 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 307 5x68 G.H5 D 341 G.H5.13
Polar TM3 R 209 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 209 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 209 3x50 G.H5 C 351 G.H5.23
Polar ICL3 Y 317 - G.h4s6 E 315 G.h4s6.09
Polar TM3 R 209 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM3 A 212 3x53 G.H5 C 351 G.H5.23
Polar C-term P 465 - G.H3 S 252 G.H3.11
Hydrophobic C-term P 465 - G.H3 S 252 G.H3.11
Van-der-waals C-term P 465 - G.H3 S 252 G.H3.11
Hydrophobic H8 N 391 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 391 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 333 6x37 G.H5 L 353 G.H5.25
Polar ICL2 K 220 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 K 220 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 K 220 - G.H5 N 347 G.H5.19
Hydrophobic H8 P 392 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 P 392 8x48 G.H5 K 349 G.H5.21
Hydrophobic TM6 L 321 6x25 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 T 332 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 T 303 5x64 G.H5 I 344 G.H5.16
Polar TM3 A 212 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 212 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 212 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 T 329 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 213 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM5 V 311 5x72 G.H5 D 341 G.H5.13
Ionic TM6 R 322 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 322 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 322 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 322 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term V 411 - G.H3 K 257 G.H3.16
Polar ICL2 R 218 - G.hns1 D 30 G.hns1.01
Hydrophobic ICL2 R 218 - G.hns1 D 30 G.hns1.01
Van-der-waals ICL2 R 218 - G.hns1 D 30 G.hns1.01
Polar ICL2 R 218 - G.S1 T 33 G.S1.01
Hydrophobic ICL2 R 218 - G.S1 T 33 G.S1.01
Van-der-waals ICL2 R 218 - G.S1 T 33 G.S1.01
Hydrophobic C-term F 469 - G.H2 R 208 G.H2.04
Van-der-waals C-term F 469 - G.H2 R 208 G.H2.04
Hydrophobic TM3 I 213 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 213 3x54 G.H5 N 347 G.H5.19
Polar TM6 R 328 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 328 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 328 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 V 304 5x65 G.H5 I 344 G.H5.16
Polar TM5 D 308 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 300 5x61 G.H5 L 353 G.H5.25
Polar TM6 T 329 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 329 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 329 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL3 N 315 - G.H4 L 308 G.H4.16
Van-der-waals ICL3 N 315 - G.H4 L 308 G.H4.16
Aromatic ICL3 Y 317 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 Y 317 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 Y 317 - G.h4s6 K 314 G.h4s6.08
Hydrophobic C-term Y 434 - G.hgh4 P 288 G.hgh4.03
Polar ICL3 P 313 - G.H4 K 304 G.H4.12
Van-der-waals ICL3 P 313 - G.H4 K 304 G.H4.12
Ionic ICL2 K 220 - G.H5 D 350 G.H5.22
Polar ICL2 K 220 - G.H5 D 350 G.H5.22
Ionic TM5 R 310 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 310 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 310 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 310 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 V 304 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 217 - G.S3 L 194 G.S3.01
Polar H8 N 393 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM3 I 213 3x54 G.H5 L 353 G.H5.25
Polar TM6 R 322 6x26 G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 322 6x26 G.S6 Y 320 G.S6.02
Hydrophobic ICL2 R 218 - G.S3 L 194 G.S3.01
Hydrophobic TM5 S 307 5x68 G.H5 I 344 G.H5.16
Ionic TM4 R 224 4x40 G.HN E 20 G.HN.44
Polar TM4 R 224 4x40 G.HN E 20 G.HN.44
Van-der-waals TM4 R 224 4x40 G.HN E 20 G.HN.44
Polar ICL2 R 218 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 218 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 218 - G.hns1 A 31 G.hns1.02
Hydrophobic C-term L 468 - G.H3 S 252 G.H3.11
Ionic TM6 R 322 6x26 G.H5 D 341 G.H5.13
Polar TM6 R 322 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 322 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 322 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM5 V 311 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 311 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 213 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 P 392 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM5 V 311 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM6 R 322 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 322 6x26 G.H5 K 345 G.H5.17
Polar ICL2 P 217 - G.H5 N 347 G.H5.19
Polar C-term A 461 - G.H3 H 248 G.H3.07
Hydrophobic C-term A 461 - G.H3 H 248 G.H3.07
Van-der-waals C-term A 461 - G.H3 H 248 G.H3.07
Hydrophobic C-term F 469 - G.H2 W 211 G.H2.07
Van-der-waals C-term F 469 - G.H2 W 211 G.H2.07
Hydrophobic TM3 R 209 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 209 3x50 G.H5 L 353 G.H5.25
Aromatic C-term F 469 - G.h2s4 F 215 G.h2s4.01
Hydrophobic C-term F 469 - G.h2s4 F 215 G.h2s4.01
Aromatic C-term R 409 - G.H3 Y 258 G.H3.17
Hydrophobic C-term R 409 - G.H3 Y 258 G.H3.17
Van-der-waals C-term R 409 - G.H3 Y 258 G.H3.17
Polar ICL3 N 315 - G.H4 N 305 G.H4.13
Van-der-waals ICL3 N 315 - G.H4 N 305 G.H4.13
Polar ICL2 R 218 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 218 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 218 - G.hns1 R 32 G.hns1.03
Hydrophobic TM7 R 390 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 R 390 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 L 321 6x25 G.h4s6 E 315 G.h4s6.09
Polar C-term R 409 - G.H3 K 257 G.H3.16
Hydrophobic C-term R 409 - G.H3 K 257 G.H3.16
Van-der-waals C-term R 409 - G.H3 K 257 G.H3.16