GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 338 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Hydrophobic | ICL2 | L | 134 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | L | 134 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM6 | T | 226 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Polar | TM2 | K | 60 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | K | 60 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | K | 60 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | C-term | V | 339 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | V | 339 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | I | 321 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Ionic | ICL3 | R | 219 | - | G.H5 | D | 361 | G.H5.10 |
Polar | ICL3 | R | 219 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | ICL3 | R | 219 | - | G.H5 | D | 361 | G.H5.10 |
Van-der-waals | ICL3 | R | 219 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | TM7 | Y | 285 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | Y | 285 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | F | 319 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Van-der-waals | C-term | F | 319 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Hydrophobic | TM3 | A | 129 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 129 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Polar | C-term | C | 334 | - | G.H3 | N | 278 | G.H3.15 |
Hydrophobic | C-term | C | 334 | - | G.H3 | N | 278 | G.H3.15 |
Polar | TM6 | T | 226 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | T | 226 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Aromatic | TM6 | Y | 221 | 6x28 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | Y | 221 | 6x28 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | Y | 221 | 6x28 | G.H5 | H | 368 | G.H5.17 |
Polar | TM3 | A | 129 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 129 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 129 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM6 | K | 225 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | I | 335 | - | G.H2 | F | 234 | G.H2.08 |
Van-der-waals | C-term | I | 335 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | ICL2 | H | 137 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Polar | ICL1 | R | 58 | 12x52 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL1 | R | 58 | 12x52 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | Y | 136 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM6 | Y | 221 | 6x28 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | TM6 | Y | 221 | 6x28 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 133 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM2 | S | 62 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | S | 62 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL3 | R | 219 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | ICL3 | R | 219 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM5 | K | 213 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | K | 213 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | F | 319 | - | G.H3 | V | 280 | G.H3.17 |
Hydrophobic | C-term | L | 338 | - | G.H3 | I | 275 | G.H3.12 |
Ionic | ICL3 | R | 219 | - | G.H5 | D | 364 | G.H5.13 |
Polar | ICL3 | R | 219 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | R | 219 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM6 | T | 226 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | T | 226 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM2 | L | 66 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | L | 66 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | Q | 341 | - | G.H2 | R | 227 | G.H2.01 |
Van-der-waals | C-term | Q | 341 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | TM5 | L | 210 | 5x65 | G.H5 | L | 367 | G.H5.16 |
Polar | TM2 | S | 62 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM7 | C | 286 | 7x54 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | L | 338 | - | G.H2 | W | 233 | G.H2.07 |
Hydrophobic | TM3 | V | 130 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | V | 130 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM2 | Y | 63 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | Y | 63 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | M | 337 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | M | 337 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | H8 | K | 290 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | K | 290 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | L | 134 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | C-term | L | 338 | - | G.H3 | I | 271 | G.H3.08 |
Hydrophobic | C-term | V | 339 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | ICL3 | F | 216 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL3 | F | 216 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | F | 216 | - | G.H5 | D | 364 | G.H5.13 |
Polar | TM3 | R | 126 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 126 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | P | 133 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL3 | F | 216 | - | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | Q | 341 | - | G.s4h3 | T | 262 | G.s4h3.14 |
Van-der-waals | C-term | Q | 341 | - | G.s4h3 | T | 262 | G.s4h3.14 |
Polar | C-term | Y | 340 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | ICL2 | L | 134 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM6 | I | 229 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | I | 229 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | V | 130 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | V | 130 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | L | 230 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Polar | H8 | R | 291 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | T | 138 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | T | 138 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | T | 138 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Y | 136 | 34x53 | G.H5 | L | 374 | G.H5.23 |
Polar | TM6 | Y | 221 | 6x28 | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM6 | Y | 221 | 6x28 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | TM6 | Y | 221 | 6x28 | G.S6 | Y | 343 | G.S6.02 |
Polar | ICL2 | P | 133 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM4 | Y | 141 | 4x38 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL3 | R | 219 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | ICL3 | R | 219 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 133 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Polar | C-term | L | 338 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | C-term | L | 338 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | TM5 | L | 210 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Polar | H8 | S | 289 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | S | 289 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | S | 289 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL3 | F | 216 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL3 | F | 216 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | L | 338 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | ICL2 | H | 137 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | H | 137 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | H | 317 | - | G.H3 | V | 280 | G.H3.17 |
Hydrophobic | ICL2 | L | 134 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | L | 134 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | H8 | K | 290 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | K | 290 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | L | 134 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | L | 134 | 34x51 | G.H5 | F | 359 | G.H5.08 |