GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | K | 354 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 354 | 6x32 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL2 | R | 267 | 34x54 | G.S1 | T | 42 | G.S1.01 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.S3 | F | 206 | G.S3.03 |
Ionic | N-term | D | 35 | - | G.H3 | R | 267 | G.H3.16 |
Polar | N-term | D | 35 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | N-term | I | 3 | - | G.S2 | V | 201 | G.S2.08 |
Polar | N-term | I | 12 | - | G.S2 | I | 194 | G.S2.01 |
Hydrophobic | N-term | I | 12 | - | G.S2 | I | 194 | G.S2.01 |
Van-der-waals | N-term | I | 12 | - | G.S2 | I | 194 | G.S2.01 |
Polar | ICL2 | H | 265 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Van-der-waals | ICL2 | H | 265 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 264 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | N-term | M | 1 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | N-term | I | 3 | - | G.H5 | I | 359 | G.H5.04 |
Polar | TM3 | A | 259 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 259 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 259 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Polar | N-term | S | 2 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Van-der-waals | N-term | S | 2 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | TM2 | S | 192 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM6 | L | 359 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | L | 340 | 5x65 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | L | 340 | 5x65 | G.H5 | Q | 371 | G.H5.16 |
Ionic | ICL2 | R | 267 | 34x54 | G.h2s4 | D | 227 | G.h2s4.03 |
Polar | ICL2 | R | 267 | 34x54 | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | N-term | V | 25 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | N-term | V | 25 | - | G.H2 | I | 222 | G.H2.08 |
Hydrophobic | N-term | K | 11 | - | G.hfs2 | G | 193 | G.hfs2.07 |
Polar | ICL2 | R | 267 | 34x54 | G.h2s4 | T | 229 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.h2s4 | T | 229 | G.h2s4.05 |
Polar | N-term | A | 24 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | N-term | A | 24 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | N-term | A | 24 | - | G.H3 | R | 267 | G.H3.16 |
Polar | N-term | E | 9 | - | G.S2 | T | 197 | G.S2.04 |
Hydrophobic | N-term | E | 9 | - | G.S2 | T | 197 | G.S2.04 |
Van-der-waals | N-term | E | 9 | - | G.S2 | T | 197 | G.S2.04 |
Polar | N-term | K | 11 | - | G.hfs2 | S | 192 | G.hfs2.06 |
Hydrophobic | N-term | K | 11 | - | G.hfs2 | S | 192 | G.hfs2.06 |
Van-der-waals | N-term | K | 11 | - | G.hfs2 | S | 192 | G.hfs2.06 |
Hydrophobic | N-term | V | 25 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 263 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM6 | P | 350 | 6x28 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | P | 350 | 6x28 | G.H5 | L | 381 | G.H5.26 |
Polar | N-term | Q | 10 | - | G.S2 | E | 196 | G.S2.03 |
Van-der-waals | N-term | Q | 10 | - | G.S2 | E | 196 | G.S2.03 |
Polar | ICL2 | L | 264 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 264 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Polar | H8 | K | 419 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | K | 419 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | N-term | I | 12 | - | G.S2 | E | 196 | G.S2.03 |
Polar | TM6 | L | 348 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM6 | L | 348 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | L | 348 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | N-term | I | 12 | - | G.S3 | F | 209 | G.S3.06 |
Van-der-waals | N-term | I | 12 | - | G.S3 | F | 209 | G.S3.06 |
Aromatic | N-term | W | 14 | - | G.H2 | R | 219 | G.H2.05 |
Polar | ICL2 | H | 266 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Aromatic | ICL2 | H | 266 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | H | 266 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | H | 266 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM6 | L | 348 | 6x26 | G.S6 | C | 346 | G.S6.01 |
Van-der-waals | TM6 | L | 348 | 6x26 | G.S6 | C | 346 | G.S6.01 |
Hydrophobic | N-term | I | 22 | - | G.H2 | R | 219 | G.H2.05 |
Van-der-waals | N-term | I | 22 | - | G.H2 | R | 219 | G.H2.05 |
Hydrophobic | N-term | L | 6 | - | G.S2 | F | 199 | G.S2.06 |
Ionic | N-term | E | 9 | - | G.H1 | R | 63 | G.H1.09 |
Polar | N-term | E | 9 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | N-term | K | 11 | - | G.S2 | F | 195 | G.S2.02 |
Van-der-waals | N-term | K | 11 | - | G.S2 | F | 195 | G.S2.02 |
Hydrophobic | N-term | M | 5 | - | G.H1 | M | 62 | G.H1.08 |
Van-der-waals | N-term | M | 5 | - | G.H1 | M | 62 | G.H1.08 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | L | 260 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 264 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Polar | ICL2 | R | 267 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | R | 267 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Polar | N-term | V | 25 | - | G.H3 | N | 266 | G.H3.15 |
Van-der-waals | N-term | V | 25 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | N-term | M | 5 | - | G.S2 | F | 199 | G.S2.06 |
Van-der-waals | N-term | M | 5 | - | G.S2 | F | 199 | G.S2.06 |
Van-der-waals | N-term | K | 11 | - | G.S2 | I | 194 | G.S2.01 |
Polar | TM6 | S | 355 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | S | 355 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | S | 355 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | L | 340 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Polar | N-term | Q | 10 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | N-term | Q | 10 | - | G.S2 | R | 198 | G.S2.05 |
Polar | TM3 | D | 255 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | D | 255 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | D | 255 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Polar | N-term | L | 6 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | N-term | L | 6 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | N-term | L | 6 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | N-term | S | 2 | - | G.S2 | V | 201 | G.S2.08 |
Van-der-waals | N-term | S | 2 | - | G.S2 | V | 201 | G.S2.08 |
Polar | ICL3 | R | 343 | - | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL3 | R | 343 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL3 | R | 343 | - | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | N-term | M | 5 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | N-term | V | 25 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Polar | ICL2 | A | 268 | 34x55 | G.hns1 | K | 40 | G.hns1.02 |
Polar | N-term | W | 14 | - | G.H2 | Q | 223 | G.H2.09 |
Hydrophobic | N-term | W | 14 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | N-term | W | 14 | - | G.H2 | Q | 223 | G.H2.09 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | L | 260 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | I | 358 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | I | 358 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | L | 252 | 3x46 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM7 | V | 417 | 7x56 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 263 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM2 | R | 190 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM6 | K | 354 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 354 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 354 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Polar | H8 | S | 418 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | S | 418 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | S | 418 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | N-term | E | 9 | - | G.H1 | V | 59 | G.H1.05 |
Hydrophobic | N-term | I | 3 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | N-term | I | 3 | - | G.H1 | H | 66 | G.H1.12 |
Polar | N-term | V | 15 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | N-term | V | 15 | - | G.H2 | Q | 223 | G.H2.09 |
Hydrophobic | N-term | M | 8 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | N-term | M | 8 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | TM3 | R | 256 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | P | 350 | 6x28 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM6 | S | 355 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | A | 259 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 259 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | N-term | I | 3 | - | G.S2 | Q | 200 | G.S2.07 |
Hydrophobic | N-term | M | 5 | - | G.h1ha | V | 67 | G.h1ha.01 |
Van-der-waals | N-term | M | 5 | - | G.h1ha | V | 67 | G.h1ha.01 |
Polar | N-term | T | 17 | - | G.H2 | Q | 223 | G.H2.09 |
Polar | TM2 | S | 192 | 2x39 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM2 | S | 192 | 2x39 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM2 | S | 192 | 2x39 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | N-term | L | 26 | - | G.H2 | R | 218 | G.H2.04 |
Aromatic | N-term | W | 14 | - | G.H2 | K | 220 | G.H2.06 |
Hydrophobic | N-term | W | 14 | - | G.H2 | K | 220 | G.H2.06 |
Van-der-waals | N-term | W | 14 | - | G.H2 | K | 220 | G.H2.06 |
Aromatic | TM3 | R | 256 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 256 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL3 | R | 343 | - | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | ICL3 | R | 343 | - | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL3 | R | 343 | - | G.H5 | R | 367 | G.H5.12 |
Polar | TM3 | L | 260 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | L | 260 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | P | 263 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 263 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | N-term | M | 5 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | N-term | M | 5 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | N-term | M | 5 | - | G.H1 | H | 66 | G.H1.12 |
Polar | ICL2 | R | 267 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | R | 267 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | R | 267 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | TM3 | L | 260 | 3x54 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | H | 265 | 34x52 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | H | 265 | 34x52 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | N-term | M | 1 | - | G.S2 | V | 201 | G.S2.08 |
Van-der-waals | N-term | M | 1 | - | G.S2 | V | 201 | G.S2.08 |
Hydrophobic | N-term | E | 9 | - | G.S2 | E | 196 | G.S2.03 |
Van-der-waals | N-term | E | 9 | - | G.S2 | E | 196 | G.S2.03 |
Hydrophobic | N-term | M | 1 | - | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | N-term | M | 1 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | L | 264 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | L | 264 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL2 | A | 268 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | A | 268 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | N-term | M | 8 | - | G.S2 | E | 196 | G.S2.03 |
Hydrophobic | TM6 | L | 348 | 6x26 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | H8 | T | 420 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | T | 420 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | T | 420 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL2 | H | 266 | 34x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | N-term | L | 26 | - | G.H3 | S | 262 | G.H3.11 |
Hydrophobic | N-term | M | 1 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Van-der-waals | N-term | M | 1 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | N-term | M | 5 | - | G.S2 | T | 197 | G.S2.04 |
Van-der-waals | N-term | M | 5 | - | G.S2 | T | 197 | G.S2.04 |
Hydrophobic | TM6 | K | 354 | 6x32 | G.H5 | L | 380 | G.H5.25 |
Polar | N-term | M | 4 | - | G.S2 | Q | 200 | G.S2.07 |
Van-der-waals | N-term | M | 4 | - | G.S2 | Q | 200 | G.S2.07 |