GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | S | 375 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | S | 375 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | TM6 | I | 242 | 6x29 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM6 | I | 242 | 6x29 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | M | 370 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | TM6 | V | 241 | 6x28 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | V | 241 | 6x28 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | R | 146 | 3x55 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM3 | R | 146 | 3x55 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | A | 149 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | S | 372 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | S | 372 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | L | 368 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | L | 368 | - | H.HA | K | 105 | H.HA.28 |
Polar | TM6 | R | 245 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | R | 245 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | R | 245 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Polar | TM3 | Y | 137 | 3x46 | G.H5 | L | 374 | G.H5.23 |
Polar | TM3 | R | 147 | 3x56 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM3 | R | 147 | 3x56 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | TM3 | R | 147 | 3x56 | G.HN | K | 42 | G.HN.51 |
Polar | C-term | E | 373 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | E | 373 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | TM3 | V | 144 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | V | 144 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | I | 242 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Polar | TM6 | N | 234 | 6x21 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM6 | N | 234 | 6x21 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM6 | N | 234 | 6x21 | G.H5 | D | 364 | G.H5.13 |
Polar | C-term | L | 371 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | L | 371 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | L | 371 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | TM3 | Y | 137 | 3x46 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | L | 371 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | L | 371 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | S | 372 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | S | 372 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | ICL3 | T | 232 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL3 | T | 232 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | TM3 | A | 141 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 141 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | S | 372 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | TM6 | E | 235 | 6x22 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL1 | P | 60 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Van-der-waals | ICL1 | P | 60 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Hydrophobic | TM2 | L | 71 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | L | 71 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | D | 140 | 3x49 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM2 | V | 68 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | V | 68 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Polar | TM2 | S | 67 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | S | 67 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL3 | T | 232 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL3 | T | 232 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | C-term | M | 370 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | M | 370 | - | H.HA | L | 106 | H.HA.29 |
Polar | C-term | E | 373 | - | H.hdhe | G | 171 | H.hdhe.04 |
Hydrophobic | C-term | E | 373 | - | H.hdhe | G | 171 | H.hdhe.04 |
Van-der-waals | C-term | E | 373 | - | H.hdhe | G | 171 | H.hdhe.04 |
Hydrophobic | TM6 | E | 235 | 6x22 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM6 | E | 235 | 6x22 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL1 | S | 59 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | ICL1 | S | 59 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Polar | ICL1 | P | 57 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | ICL1 | P | 57 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | ICL1 | P | 57 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL3 | T | 232 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Polar | TM3 | R | 146 | 3x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | R | 146 | 3x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | R | 146 | 3x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | G | 374 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | G | 374 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Polar | TM2 | S | 67 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM2 | S | 67 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | S | 67 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | C-term | I | 380 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Polar | ICL1 | T | 62 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ICL1 | T | 62 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | C-term | S | 372 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | S | 372 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Polar | ICL1 | P | 60 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ICL1 | P | 60 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | ICL1 | P | 60 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Polar | TM3 | R | 147 | 3x56 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM3 | R | 147 | 3x56 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM3 | R | 147 | 3x56 | G.HN | T | 43 | G.HN.52 |
Polar | TM3 | S | 148 | 3x57 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | S | 148 | 3x57 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM3 | S | 148 | 3x57 | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | ICL1 | P | 65 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ICL1 | P | 65 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | C-term | E | 373 | - | H.HA | K | 94 | H.HA.17 |
Polar | C-term | S | 369 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | S | 369 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | S | 369 | - | H.HA | K | 105 | H.HA.28 |
Polar | C-term | I | 380 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | I | 380 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | I | 380 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | ICL3 | Y | 231 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL3 | Y | 231 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM5 | A | 219 | 5x64 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | E | 373 | - | H.HE | V | 174 | H.HE.02 |
Van-der-waals | C-term | E | 373 | - | H.HE | V | 174 | H.HE.02 |
Van-der-waals | TM6 | R | 245 | 6x32 | G.H5 | L | 376 | G.H5.25 |
Polar | TM6 | N | 234 | 6x21 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM6 | N | 234 | 6x21 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | TM6 | N | 234 | 6x21 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM7 | F | 310 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | E | 373 | - | H.HA | G | 95 | H.HA.18 |
Hydrophobic | C-term | E | 373 | - | H.HA | G | 95 | H.HA.18 |
Van-der-waals | C-term | E | 373 | - | H.HA | G | 95 | H.HA.18 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | C-term | M | 370 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | E | 373 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | E | 373 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | TM3 | R | 146 | 3x55 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | R | 146 | 3x55 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM6 | N | 234 | 6x21 | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | TM6 | N | 234 | 6x21 | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | TM3 | R | 147 | 3x56 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | R | 147 | 3x56 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | TM3 | R | 147 | 3x56 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM2 | S | 67 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | S | 67 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | M | 370 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | M | 370 | - | H.HA | K | 105 | H.HA.28 |
Polar | TM3 | R | 147 | 3x56 | G.HN | S | 39 | G.HN.48 |
Polar | C-term | M | 370 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | M | 370 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | M | 370 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | M | 370 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | C-term | L | 368 | - | H.hahb | H | 107 | H.hahb.01 |
Polar | C-term | S | 378 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | S | 378 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | ICL1 | S | 59 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | C-term | L | 371 | - | H.HB | M | 123 | H.HB.10 |
Van-der-waals | C-term | L | 371 | - | H.HB | M | 123 | H.HB.10 |
Hydrophobic | TM6 | I | 242 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | I | 242 | 6x29 | G.H5 | L | 371 | G.H5.20 |