GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | I | 242 | 6x29 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | I | 242 | 6x29 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | G | 374 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | TM6 | E | 235 | 6x22 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL1 | P | 65 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL1 | P | 65 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | L | 371 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Van-der-waals | C-term | L | 371 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | C-term | I | 327 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | C-term | A | 385 | - | G.S2 | I | 190 | G.S2.02 |
Polar | TM6 | I | 242 | 6x29 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | I | 242 | 6x29 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL3 | Y | 231 | - | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | ICL3 | Y | 231 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | C-term | Q | 328 | - | G.H4 | L | 310 | G.H4.12 |
Van-der-waals | C-term | Q | 328 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | TM6 | V | 241 | 6x28 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | A | 141 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | I | 380 | - | G.H2 | K | 215 | G.H2.06 |
Van-der-waals | C-term | I | 380 | - | G.H2 | K | 215 | G.H2.06 |
Polar | ICL1 | S | 63 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL1 | S | 63 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | C-term | I | 327 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | TM6 | R | 245 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | R | 245 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | Y | 137 | 3x46 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | Y | 137 | 3x46 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | M | 238 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | M | 238 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Polar | C-term | A | 367 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | C-term | S | 322 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | C-term | S | 322 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | C-term | S | 322 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Polar | C-term | A | 385 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | A | 385 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | C-term | L | 368 | - | G.H3 | T | 257 | G.H3.11 |
Polar | C-term | L | 368 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 368 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 368 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM6 | V | 241 | 6x28 | G.H5 | V | 359 | G.H5.26 |
Polar | C-term | I | 327 | - | G.S6 | I | 324 | G.S6.01 |
Polar | C-term | E | 387 | - | G.h1ha | S | 65 | G.h1ha.02 |
Hydrophobic | C-term | E | 387 | - | G.h1ha | S | 65 | G.h1ha.02 |
Van-der-waals | C-term | E | 387 | - | G.h1ha | S | 65 | G.h1ha.02 |
Polar | TM7 | Y | 311 | 7x54 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | Y | 311 | 7x54 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | Y | 311 | 7x54 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | K | 325 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | C-term | R | 324 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM3 | V | 144 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | V | 144 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Polar | ICL1 | S | 59 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | ICL3 | Y | 231 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL3 | Y | 231 | - | G.H5 | L | 349 | G.H5.16 |
Polar | TM3 | Y | 137 | 3x46 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | Y | 137 | 3x46 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | Y | 137 | 3x46 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | W | 329 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | W | 329 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | TM3 | V | 144 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | V | 144 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | Y | 231 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL3 | Y | 231 | - | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | L | 371 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | L | 371 | - | G.H2 | I | 217 | G.H2.08 |
Polar | C-term | R | 324 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Hydrophobic | C-term | R | 324 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Van-der-waals | C-term | R | 324 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Hydrophobic | C-term | P | 323 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | C-term | W | 329 | - | G.H5 | A | 342 | G.H5.09 |
Polar | TM6 | N | 234 | 6x21 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Polar | TM2 | S | 67 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | S | 67 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | S | 67 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | A | 385 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | A | 385 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | C-term | L | 371 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | H | 383 | - | G.S2 | I | 190 | G.S2.02 |
Van-der-waals | C-term | H | 383 | - | G.S2 | I | 190 | G.S2.02 |
Polar | C-term | H | 383 | - | G.S2 | I | 189 | G.S2.01 |
Van-der-waals | C-term | H | 383 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | TM7 | F | 310 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | M | 370 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | A | 367 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | A | 367 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | I | 382 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | I | 382 | - | G.S2 | E | 191 | G.S2.03 |
Polar | TM2 | S | 67 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | S | 67 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | S | 67 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | I | 382 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | TM6 | F | 246 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | F | 246 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | A | 141 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | S | 148 | 3x57 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | I | 380 | - | G.H2 | H | 218 | G.H2.09 |
Van-der-waals | C-term | I | 380 | - | G.H2 | H | 218 | G.H2.09 |
Polar | C-term | G | 374 | - | G.H2 | H | 218 | G.H2.09 |
Polar | C-term | H | 383 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | H | 383 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | C-term | L | 371 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 371 | - | G.H3 | Y | 261 | G.H3.15 |
Ionic | C-term | R | 324 | - | G.H4 | D | 315 | G.H4.17 |
Polar | C-term | R | 324 | - | G.H4 | D | 315 | G.H4.17 |
Van-der-waals | C-term | R | 324 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | C-term | E | 326 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | C-term | E | 326 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | TM6 | N | 234 | 6x21 | G.H5 | L | 349 | G.H5.16 |
Polar | TM3 | D | 140 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | D | 140 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | D | 140 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | I | 380 | - | G.S2 | I | 189 | G.S2.01 |