GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | W | 398 | - | G.S2 | P | 189 | G.S2.05 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | H | 155 | - | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | C-term | R | 408 | - | G.s4h3 | A | 236 | G.s4h3.09 |
Van-der-waals | C-term | R | 408 | - | G.s4h3 | A | 236 | G.s4h3.09 |
Hydrophobic | C-term | Y | 403 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Van-der-waals | C-term | Y | 403 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Polar | C-term | R | 417 | - | H.HD | E | 146 | H.HD.12 |
Hydrophobic | C-term | R | 417 | - | H.HD | E | 146 | H.HD.12 |
Van-der-waals | C-term | R | 417 | - | H.HD | E | 146 | H.HD.12 |
Ionic | TM4 | R | 157 | 4x38 | G.HN | D | 31 | G.HN.53 |
Polar | TM4 | R | 157 | 4x38 | G.HN | D | 31 | G.HN.53 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.HN | D | 31 | G.HN.53 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | D | 31 | G.HN.53 |
Hydrophobic | H8 | D | 359 | 8x50 | G.H5 | V | 355 | G.H5.26 |
Polar | ICL3 | P | 277 | - | G.H4 | D | 303 | G.H4.09 |
Hydrophobic | ICL3 | P | 277 | - | G.H4 | D | 303 | G.H4.09 |
Van-der-waals | ICL3 | P | 277 | - | G.H4 | D | 303 | G.H4.09 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | V | 151 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Polar | TM2 | R | 80 | 2x37 | G.H5 | R | 350 | G.H5.21 |
Hydrophobic | TM2 | R | 80 | 2x37 | G.H5 | R | 350 | G.H5.21 |
Van-der-waals | TM2 | R | 80 | 2x37 | G.H5 | R | 350 | G.H5.21 |
Polar | ICL3 | G | 278 | - | G.H4 | D | 303 | G.H4.09 |
Hydrophobic | ICL3 | G | 278 | - | G.H4 | D | 303 | G.H4.09 |
Van-der-waals | ICL3 | G | 278 | - | G.H4 | D | 303 | G.H4.09 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Polar | TM3 | R | 147 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | L | 393 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | L | 393 | - | G.H2 | H | 214 | G.H2.09 |
Polar | ICL2 | P | 154 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | P | 154 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Ionic | C-term | R | 417 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Polar | C-term | R | 417 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Hydrophobic | C-term | R | 417 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Van-der-waals | C-term | R | 417 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | R | 417 | - | H.hdhe | Y | 147 | H.hdhe.01 |
Hydrophobic | C-term | F | 434 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | F | 434 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Polar | TM3 | R | 147 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Aromatic | C-term | W | 398 | - | G.S2 | Y | 188 | G.S2.04 |
Hydrophobic | C-term | W | 398 | - | G.S2 | Y | 188 | G.S2.04 |
Van-der-waals | C-term | W | 398 | - | G.S2 | Y | 188 | G.S2.04 |
Polar | TM2 | M | 82 | 2x39 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | E | 351 | G.H5.22 |
Polar | TM6 | S | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | S | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | S | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Polar | TM5 | S | 274 | 5x80 | G.H4 | R | 299 | G.H4.05 |
Hydrophobic | TM5 | S | 274 | 5x80 | G.H4 | R | 299 | G.H4.05 |
Van-der-waals | TM5 | S | 274 | 5x80 | G.H4 | R | 299 | G.H4.05 |
Polar | TM2 | K | 81 | 2x38 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | K | 81 | 2x38 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | K | 81 | 2x38 | G.H5 | E | 351 | G.H5.22 |
Polar | C-term | W | 398 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | C-term | W | 398 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | W | 398 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM2 | R | 80 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | R | 80 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | C-term | H | 405 | - | H.HA | L | 74 | H.HA.10 |
Van-der-waals | C-term | H | 405 | - | H.HA | L | 74 | H.HA.10 |
Hydrophobic | TM6 | K | 290 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | K | 290 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | Q | 292 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | Q | 292 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | C-term | R | 417 | - | G.s4h3 | V | 234 | G.s4h3.07 |
Van-der-waals | C-term | R | 417 | - | G.s4h3 | V | 234 | G.s4h3.07 |
Polar | TM3 | A | 150 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 150 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | H8 | Q | 356 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | Q | 356 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Polar | C-term | R | 417 | - | H.HD | R | 145 | H.HD.11 |
Ionic | C-term | R | 407 | - | H.HB | E | 113 | H.HB.13 |
Polar | TM2 | R | 80 | 2x37 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM2 | R | 80 | 2x37 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM2 | R | 80 | 2x37 | G.H5 | N | 353 | G.H5.24 |
Polar | C-term | H | 405 | - | H.HA | Q | 77 | H.HA.13 |
Hydrophobic | C-term | H | 405 | - | H.HA | Q | 77 | H.HA.13 |
Van-der-waals | C-term | H | 405 | - | H.HA | Q | 77 | H.HA.13 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | C-term | F | 434 | - | G.H3 | I | 254 | G.H3.12 |
Polar | TM4 | P | 158 | 4x39 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM4 | P | 158 | 4x39 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | TM4 | P | 158 | 4x39 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | TM4 | R | 157 | 4x38 | G.HN | K | 30 | G.HN.52 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.HN | K | 30 | G.HN.52 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | K | 30 | G.HN.52 |
Hydrophobic | C-term | A | 406 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | ICL2 | H | 155 | - | G.S1 | L | 36 | G.S1.02 |
Van-der-waals | ICL2 | H | 155 | - | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | ICL2 | H | 155 | - | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | H | 155 | - | G.S3 | I | 195 | G.S3.01 |
Ionic | C-term | R | 408 | - | G.s1h1 | E | 45 | G.s1h1.04 |
Polar | C-term | R | 408 | - | G.s1h1 | E | 45 | G.s1h1.04 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 154 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL3 | A | 282 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Polar | ICL3 | S | 276 | - | G.H4 | R | 302 | G.H4.08 |
Van-der-waals | ICL3 | S | 276 | - | G.H4 | R | 302 | G.H4.08 |
Polar | C-term | R | 417 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | L | 416 | - | H.HA | T | 92 | H.HA.28 |
Van-der-waals | C-term | L | 416 | - | H.HA | T | 92 | H.HA.28 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 150 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | H | 155 | - | G.H5 | I | 344 | G.H5.15 |
Ionic | C-term | R | 407 | - | H.hbhc | D | 115 | H.hbhc.01 |
Polar | C-term | R | 407 | - | H.hbhc | D | 115 | H.hbhc.01 |
Hydrophobic | C-term | R | 407 | - | H.hbhc | D | 115 | H.hbhc.01 |
Van-der-waals | C-term | R | 407 | - | H.hbhc | D | 115 | H.hbhc.01 |
Hydrophobic | TM2 | K | 81 | 2x38 | G.H5 | F | 352 | G.H5.23 |
Polar | ICL3 | S | 276 | - | G.H4 | R | 299 | G.H4.05 |
Hydrophobic | ICL3 | S | 276 | - | G.H4 | R | 299 | G.H4.05 |
Van-der-waals | ICL3 | S | 276 | - | G.H4 | R | 299 | G.H4.05 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM3 | E | 146 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Polar | TM2 | D | 83 | 2x40 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM2 | D | 83 | 2x40 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | C-term | F | 434 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | R | 417 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Aromatic | C-term | F | 434 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | F | 434 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | F | 434 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | ICL3 | S | 276 | - | G.H4 | D | 303 | G.H4.09 |
Van-der-waals | ICL3 | S | 276 | - | G.H4 | D | 303 | G.H4.09 |
Hydrophobic | TM6 | K | 290 | 6x30 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM6 | K | 290 | 6x30 | G.H5 | L | 345 | G.H5.16 |