GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | F | 434 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | F | 434 | - | G.H2 | K | 210 | G.H2.05 |
Polar | ICL2 | H | 155 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | H | 155 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | C-term | R | 395 | - | G.hgh4 | G | 293 | G.hgh4.07 |
Van-der-waals | C-term | R | 395 | - | G.hgh4 | G | 293 | G.hgh4.07 |
Polar | C-term | R | 417 | - | G.h1ha | Y | 61 | G.h1ha.04 |
Hydrophobic | C-term | R | 417 | - | G.h1ha | Y | 61 | G.h1ha.04 |
Van-der-waals | C-term | R | 417 | - | G.h1ha | Y | 61 | G.h1ha.04 |
Ionic | C-term | R | 395 | - | G.H4 | E | 299 | G.H4.05 |
Polar | C-term | R | 395 | - | G.H4 | E | 299 | G.H4.05 |
Hydrophobic | C-term | R | 395 | - | G.H4 | E | 299 | G.H4.05 |
Van-der-waals | C-term | R | 395 | - | G.H4 | E | 299 | G.H4.05 |
Polar | C-term | Y | 403 | - | G.HG | K | 272 | G.HG.01 |
Polar | C-term | A | 406 | - | G.H5 | K | 331 | G.H5.02 |
Van-der-waals | C-term | A | 406 | - | G.H5 | K | 331 | G.H5.02 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | P | 419 | - | H.HA | E | 65 | H.HA.03 |
Polar | ICL1 | K | 78 | - | G.h2s4 | T | 220 | G.h2s4.05 |
Polar | TM2 | R | 80 | 2x37 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM2 | R | 80 | 2x37 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | TM2 | R | 80 | 2x37 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Polar | TM3 | R | 147 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | C-term | W | 398 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | ICL2 | P | 154 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | P | 154 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | P | 420 | - | H.HA | Y | 69 | H.HA.07 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | R | 417 | - | G.h1ha | G | 60 | G.h1ha.03 |
Van-der-waals | C-term | R | 417 | - | G.h1ha | G | 60 | G.h1ha.03 |
Hydrophobic | C-term | P | 418 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Polar | TM2 | M | 82 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Polar | TM6 | S | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | S | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | S | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Polar | TM6 | K | 290 | 6x30 | G.H5 | L | 354 | G.H5.25 |
Polar | TM2 | K | 81 | 2x38 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | K | 29 | G.HN.53 |
Ionic | TM2 | R | 80 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Polar | TM2 | R | 80 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM2 | R | 80 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | R | 80 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.hns1 | R | 32 | G.hns1.03 |
Polar | C-term | Y | 403 | - | G.H5 | N | 332 | G.H5.03 |
Hydrophobic | TM6 | K | 290 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL3 | P | 277 | - | G.H4 | Y | 297 | G.H4.03 |
Van-der-waals | ICL3 | P | 277 | - | G.H4 | Y | 297 | G.H4.03 |
Ionic | TM2 | R | 80 | 2x37 | G.h3s5 | D | 262 | G.h3s5.02 |
Hydrophobic | ICL3 | R | 279 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | R | 279 | - | G.H5 | F | 335 | G.H5.06 |
Ionic | TM4 | R | 157 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 157 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | R | 417 | - | H.HA | E | 65 | H.HA.03 |
Van-der-waals | C-term | R | 417 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | I | 345 | G.H5.16 |
Polar | TM6 | S | 293 | 6x33 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM6 | S | 293 | 6x33 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM6 | S | 293 | 6x33 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | A | 285 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | P | 154 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | P | 420 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | ICL2 | H | 155 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | H | 155 | - | G.S3 | L | 195 | G.S3.01 |
Polar | ICL3 | P | 277 | - | G.H4 | D | 298 | G.H4.04 |
Hydrophobic | ICL3 | P | 277 | - | G.H4 | D | 298 | G.H4.04 |
Van-der-waals | ICL3 | P | 277 | - | G.H4 | D | 298 | G.H4.04 |
Hydrophobic | C-term | P | 419 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | P | 419 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | P | 418 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | C-term | P | 418 | - | H.HA | E | 65 | H.HA.03 |
Van-der-waals | C-term | P | 418 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 150 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM3 | E | 146 | 3x49 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | C-term | W | 398 | - | G.S6 | F | 324 | G.S6.05 |
Van-der-waals | C-term | W | 398 | - | G.S6 | F | 324 | G.S6.05 |
Polar | C-term | R | 417 | - | G.h1ha | S | 62 | G.h1ha.05 |
Hydrophobic | C-term | R | 417 | - | G.h1ha | S | 62 | G.h1ha.05 |
Van-der-waals | C-term | R | 417 | - | G.h1ha | S | 62 | G.h1ha.05 |
Ionic | H8 | R | 364 | 8x55 | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | H8 | R | 364 | 8x55 | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | H8 | R | 364 | 8x55 | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | ICL2 | H | 155 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | ICL2 | H | 155 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | H | 155 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | C-term | R | 417 | - | G.h1ha | D | 59 | G.h1ha.02 |
Hydrophobic | C-term | R | 417 | - | G.h1ha | D | 59 | G.h1ha.02 |
Van-der-waals | C-term | R | 417 | - | G.h1ha | D | 59 | G.h1ha.02 |
Polar | ICL1 | K | 78 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Hydrophobic | ICL1 | K | 78 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Van-der-waals | ICL1 | K | 78 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Hydrophobic | C-term | R | 417 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | TM4 | P | 160 | 4x41 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | P | 160 | 4x41 | G.HN | R | 24 | G.HN.48 |
Polar | C-term | P | 420 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | C-term | P | 420 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | P | 420 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | C-term | G | 415 | - | G.h1ha | D | 59 | G.h1ha.02 |
Van-der-waals | C-term | G | 415 | - | G.h1ha | D | 59 | G.h1ha.02 |