GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Van-der-waals | ICL3 | S | 276 | - | G.hgh4 | P | 328 | G.hgh4.18 |
Ionic | ICL1 | K | 78 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | ICL1 | K | 78 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | ICL1 | K | 78 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | P | 154 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | R | 80 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | R | 80 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM5 | W | 273 | 5x79 | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | TM5 | W | 273 | 5x79 | G.hgh4 | T | 325 | G.hgh4.15 |
Polar | TM3 | E | 146 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | E | 146 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | E | 146 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Ionic | TM2 | R | 80 | 2x37 | G.H5 | E | 392 | G.H5.24 |
Polar | TM2 | R | 80 | 2x37 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | S | 274 | 5x80 | G.hgh4 | P | 328 | G.hgh4.18 |
Polar | ICL3 | P | 277 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | ICL3 | P | 277 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | P | 277 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Aromatic | ICL1 | W | 74 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | ICL1 | W | 74 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | ICL1 | W | 74 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | ICL3 | S | 276 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Hydrophobic | ICL3 | S | 276 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Van-der-waals | ICL3 | S | 276 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Polar | ICL3 | G | 278 | - | G.H4 | Y | 339 | G.H4.08 |
Polar | ICL3 | P | 277 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL3 | P | 277 | - | G.H4 | Y | 339 | G.H4.08 |
Van-der-waals | ICL3 | P | 277 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | TM2 | K | 81 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | K | 81 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | K | 81 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | C-term | F | 434 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Hydrophobic | C-term | F | 434 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Van-der-waals | C-term | F | 434 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | H | 155 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Polar | TM3 | R | 147 | 3x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | E | 392 | G.H5.24 |
Polar | TM2 | M | 82 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL3 | P | 277 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Hydrophobic | ICL3 | P | 277 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Van-der-waals | ICL3 | P | 277 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Hydrophobic | TM6 | S | 293 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | S | 293 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | A | 275 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Hydrophobic | C-term | F | 434 | - | G.H3 | N | 279 | G.H3.15 |
Van-der-waals | C-term | F | 434 | - | G.H3 | N | 279 | G.H3.15 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | F | 434 | - | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 393 | G.H5.25 |
Polar | TM2 | R | 80 | 2x37 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM2 | R | 80 | 2x37 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | TM2 | R | 80 | 2x37 | G.H5 | R | 389 | G.H5.21 |
Polar | TM2 | K | 81 | 2x38 | G.H5 | Q | 390 | G.H5.22 |
Polar | ICL1 | P | 73 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | ICL1 | P | 73 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | ICL1 | P | 73 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | ICL3 | G | 278 | - | G.S6 | F | 363 | G.S6.05 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 150 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL3 | S | 276 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Hydrophobic | ICL3 | S | 276 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Van-der-waals | ICL3 | S | 276 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | P | 277 | - | G.S6 | F | 363 | G.S6.05 |
Hydrophobic | ICL1 | W | 74 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 388 | G.H5.20 |
Polar | H8 | Q | 356 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | Q | 356 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | Q | 356 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | A | 280 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | A | 280 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | P | 154 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | P | 154 | - | G.H5 | H | 387 | G.H5.19 |
Polar | ICL3 | A | 275 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | ICL3 | A | 275 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | A | 275 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Polar | TM7 | Y | 352 | 7x53 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | Y | 352 | 7x53 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | Y | 352 | 7x53 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | P | 277 | - | G.H4 | K | 338 | G.H4.07 |
Van-der-waals | ICL3 | P | 277 | - | G.H4 | K | 338 | G.H4.07 |
Polar | C-term | S | 432 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | A | 285 | 6x25 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL3 | P | 277 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Van-der-waals | ICL3 | P | 277 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Hydrophobic | C-term | F | 434 | - | G.H2 | W | 234 | G.H2.07 |
Polar | ICL3 | A | 275 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Hydrophobic | ICL3 | A | 275 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Van-der-waals | ICL3 | A | 275 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | L | 388 | G.H5.20 |
Polar | TM4 | R | 157 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM2 | L | 86 | 2x43 | G.H5 | E | 392 | G.H5.24 |
Polar | TM3 | R | 147 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | Y | 391 | G.H5.23 |