GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 15.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | Y | 403 | - | G.s4h3 | D | 234 | G.s4h3.12 |
Hydrophobic | C-term | Y | 403 | - | G.s4h3 | D | 234 | G.s4h3.12 |
Van-der-waals | C-term | Y | 403 | - | G.s4h3 | D | 234 | G.s4h3.12 |
Hydrophobic | ICL1 | K | 78 | - | G.h4s6 | K | 313 | G.h4s6.11 |
Aromatic | C-term | F | 434 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | C-term | F | 434 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | C-term | F | 434 | - | G.H3 | H | 252 | G.H3.15 |
Polar | ICL1 | R | 79 | - | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL1 | R | 79 | - | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | ICL1 | R | 79 | - | G.H5 | F | 350 | G.H5.26 |
Polar | TM4 | R | 157 | 4x38 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | I | 340 | G.H5.16 |
Polar | C-term | R | 395 | - | G.H3 | H | 244 | G.H3.07 |
Aromatic | C-term | R | 395 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | C-term | R | 395 | - | G.H3 | H | 244 | G.H3.07 |
Van-der-waals | C-term | R | 395 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | ICL1 | A | 75 | - | G.h4s6 | V | 312 | G.h4s6.10 |
Hydrophobic | ICL1 | G | 76 | - | G.h4s6 | V | 312 | G.h4s6.10 |
Van-der-waals | ICL1 | G | 76 | - | G.h4s6 | V | 312 | G.h4s6.10 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Polar | TM4 | R | 157 | 4x38 | G.h2s4 | G | 213 | G.h2s4.03 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.h2s4 | G | 213 | G.h2s4.03 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.h2s4 | G | 213 | G.h2s4.03 |
Hydrophobic | ICL1 | K | 78 | - | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | ICL1 | K | 78 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM3 | L | 153 | 3x56 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | TM3 | L | 153 | 3x56 | G.hns1 | R | 28 | G.hns1.03 |
Polar | C-term | Q | 396 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | ICL1 | P | 73 | - | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | ICL1 | P | 73 | - | G.h4s6 | D | 311 | G.h4s6.09 |
Polar | C-term | W | 398 | - | G.HG | I | 281 | G.HG.17 |
Hydrophobic | C-term | W | 398 | - | G.HG | I | 281 | G.HG.17 |
Van-der-waals | C-term | W | 398 | - | G.HG | I | 281 | G.HG.17 |
Hydrophobic | C-term | F | 434 | - | G.H2 | W | 207 | G.H2.07 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 349 | G.H5.25 |
Ionic | ICL1 | K | 78 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | ICL1 | K | 78 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | ICL1 | K | 78 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | ICL1 | K | 78 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | C-term | W | 398 | - | G.s4h3 | V | 229 | G.s4h3.07 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | A | 150 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | C-term | W | 398 | - | G.s4h3 | D | 227 | G.s4h3.05 |
Hydrophobic | ICL1 | P | 77 | - | G.h3s5 | T | 257 | G.h3s5.02 |
Van-der-waals | ICL1 | P | 77 | - | G.h3s5 | T | 257 | G.h3s5.02 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | A | 285 | 6x25 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | C-term | F | 434 | - | G.H3 | I | 249 | G.H3.12 |
Van-der-waals | C-term | F | 434 | - | G.H3 | I | 249 | G.H3.12 |
Polar | ICL1 | R | 79 | - | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | ICL1 | R | 79 | - | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | ICL1 | R | 79 | - | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | ICL2 | H | 155 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | C-term | W | 398 | - | G.s4h3 | N | 237 | G.s4h3.15 |
Van-der-waals | C-term | W | 398 | - | G.s4h3 | N | 237 | G.s4h3.15 |
Polar | ICL1 | K | 78 | - | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | C-term | W | 398 | - | G.hgh4 | C | 282 | G.hgh4.01 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | H | 155 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL1 | K | 78 | - | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | ICL1 | K | 78 | - | G.H5 | K | 345 | G.H5.21 |
Ionic | TM3 | R | 152 | 3x55 | G.HN | E | 24 | G.HN.52 |
Polar | TM3 | R | 152 | 3x55 | G.HN | E | 24 | G.HN.52 |
Polar | TM2 | M | 82 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | G | 348 | G.H5.24 |
Aromatic | C-term | F | 434 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | C-term | F | 434 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Van-der-waals | C-term | F | 434 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL1 | P | 77 | - | G.h4s6 | V | 312 | G.h4s6.10 |
Van-der-waals | ICL1 | P | 77 | - | G.h4s6 | V | 312 | G.h4s6.10 |
Aromatic | C-term | W | 398 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | C-term | W | 398 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | ICL1 | R | 79 | - | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL2 | H | 155 | - | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | H | 155 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | TM6 | S | 293 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | S | 293 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM6 | A | 285 | 6x25 | G.H5 | K | 341 | G.H5.17 |
Polar | TM3 | R | 149 | 3x52 | G.HN | A | 23 | G.HN.51 |
Hydrophobic | ICL2 | H | 155 | - | G.S1 | V | 30 | G.S1.02 |
Van-der-waals | ICL2 | H | 155 | - | G.s2s3 | K | 188 | G.s2s3.01 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL1 | K | 78 | - | G.h4s6 | V | 312 | G.h4s6.10 |
Van-der-waals | ICL1 | K | 78 | - | G.h4s6 | V | 312 | G.h4s6.10 |
Polar | C-term | A | 433 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | C-term | A | 433 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | A | 433 | - | G.H3 | S | 248 | G.H3.11 |
Ionic | ICL1 | K | 78 | - | G.H5 | E | 342 | G.H5.18 |
Polar | ICL1 | K | 78 | - | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | ICL1 | K | 78 | - | G.H5 | E | 342 | G.H5.18 |
Van-der-waals | ICL1 | K | 78 | - | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | ICL1 | R | 79 | - | G.H5 | D | 346 | G.H5.22 |
Polar | ICL2 | P | 154 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | P | 154 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | V | 151 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM3 | R | 149 | 3x52 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | TM3 | R | 149 | 3x52 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM3 | L | 153 | 3x56 | G.hns1 | A | 27 | G.hns1.02 |
Ionic | C-term | R | 395 | - | G.H3 | E | 241 | G.H3.04 |
Polar | C-term | R | 395 | - | G.H3 | E | 241 | G.H3.04 |
Hydrophobic | C-term | A | 433 | - | G.H3 | L | 245 | G.H3.08 |
Ionic | C-term | H | 404 | - | H.HD | E | 141 | H.HD.12 |
Hydrophobic | TM2 | R | 80 | 2x37 | G.h3s5 | T | 257 | G.h3s5.02 |
Van-der-waals | TM2 | R | 80 | 2x37 | G.h3s5 | T | 257 | G.h3s5.02 |
Polar | ICL2 | G | 156 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | G | 156 | - | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | G | 156 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | ICL2 | H | 155 | - | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | H | 155 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | C-term | L | 393 | - | G.h4s6 | L | 306 | G.h4s6.01 |
Van-der-waals | C-term | L | 393 | - | G.h4s6 | L | 306 | G.h4s6.01 |