GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 70.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL1 | K | 78 | - | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Polar | H8 | R | 361 | 8x52 | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | H8 | R | 361 | 8x52 | G.h4s6 | T | 317 | G.h4s6.10 |
Van-der-waals | H8 | R | 361 | 8x52 | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | ICL2 | P | 154 | - | G.S3 | L | 195 | G.S3.01 |
Polar | TM4 | R | 157 | 4x38 | G.HN | S | 27 | G.HN.51 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.HN | S | 27 | G.HN.51 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | S | 27 | G.HN.51 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | Y | 403 | - | H.HA | P | 71 | H.HA.09 |
Van-der-waals | C-term | Y | 403 | - | H.HA | P | 71 | H.HA.09 |
Polar | TM6 | A | 289 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | A | 289 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL1 | K | 78 | - | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | ICL1 | K | 78 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL2 | G | 156 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | A | 150 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | F | 434 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | F | 434 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | ICL1 | W | 74 | - | G.H3 | F | 260 | G.H3.18 |
Van-der-waals | ICL1 | W | 74 | - | G.H3 | F | 260 | G.H3.18 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | M | 82 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Polar | TM3 | R | 147 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | ICL2 | G | 156 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | C-term | R | 395 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | TM6 | Q | 292 | 6x32 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | W | 398 | - | G.S2 | N | 188 | G.S2.04 |
Van-der-waals | C-term | W | 398 | - | G.S2 | N | 188 | G.S2.04 |
Polar | TM6 | S | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | S | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | S | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL1 | W | 74 | - | G.H3 | N | 258 | G.H3.16 |
Van-der-waals | ICL1 | W | 74 | - | G.H3 | N | 258 | G.H3.16 |
Polar | ICL1 | K | 78 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL1 | K | 78 | - | G.H5 | N | 348 | G.H5.19 |
Ionic | H8 | D | 359 | 8x50 | G.H5 | K | 350 | G.H5.21 |
Polar | H8 | D | 359 | 8x50 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | H8 | D | 359 | 8x50 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | D | 359 | 8x50 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | TM6 | A | 289 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | H | 155 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | H | 155 | - | G.hns1 | R | 31 | G.hns1.02 |
Polar | ICL2 | H | 155 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | H | 155 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | H | 155 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | H | 155 | - | G.S1 | I | 34 | G.S1.02 |
Van-der-waals | ICL2 | H | 155 | - | G.S1 | I | 34 | G.S1.02 |
Hydrophobic | TM6 | K | 290 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | K | 290 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | Q | 292 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | Q | 292 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Polar | ICL1 | G | 76 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | ICL1 | G | 76 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Van-der-waals | ICL1 | G | 76 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | ICL1 | W | 74 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | ICL1 | W | 74 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | C-term | W | 398 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | S | 25 | G.HN.49 |
Hydrophobic | C-term | A | 433 | - | G.H3 | S | 253 | G.H3.11 |
Polar | C-term | Y | 394 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | C-term | Y | 394 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | Y | 394 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | ICL1 | W | 74 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | ICL1 | W | 74 | - | G.H3 | W | 259 | G.H3.17 |
Polar | TM6 | A | 285 | 6x25 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | A | 285 | 6x25 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | A | 285 | 6x25 | G.H5 | Q | 346 | G.H5.17 |
Polar | TM6 | L | 286 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Polar | TM4 | R | 157 | 4x38 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | C-term | H | 390 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | F | 434 | - | G.H3 | I | 254 | G.H3.12 |
Van-der-waals | C-term | F | 434 | - | G.H3 | I | 254 | G.H3.12 |
Polar | TM4 | R | 157 | 4x38 | G.HN | L | 23 | G.HN.47 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | L | 23 | G.HN.47 |
Polar | TM4 | R | 157 | 4x38 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | R | 157 | 4x38 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | R | 157 | 4x38 | G.HN | R | 24 | G.HN.48 |
Polar | ICL3 | R | 279 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | ICL3 | R | 279 | - | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | ICL3 | R | 279 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | R | 147 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 147 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | Y | 394 | - | G.S3 | K | 198 | G.S3.04 |
Van-der-waals | C-term | Y | 394 | - | G.S3 | K | 198 | G.S3.04 |
Hydrophobic | ICL2 | H | 155 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | H | 155 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM2 | M | 82 | 2x39 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | L | 153 | 3x56 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | TM3 | L | 153 | 3x56 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | P | 277 | - | G.H4 | E | 298 | G.H4.04 |
Polar | ICL1 | R | 79 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL1 | R | 79 | - | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | ICL1 | R | 79 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | V | 151 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | A | 150 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 150 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL1 | A | 75 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | ICL2 | P | 154 | - | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | L | 286 | 6x26 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM6 | L | 286 | 6x26 | G.H5 | I | 345 | G.H5.16 |
Polar | TM4 | P | 158 | 4x39 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM4 | P | 158 | 4x39 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | P | 158 | 4x39 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | C-term | W | 398 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | C-term | F | 434 | - | G.H2 | W | 212 | G.H2.07 |
Aromatic | C-term | F | 434 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | C-term | F | 434 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | F | 434 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Polar | C-term | Q | 391 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | Q | 391 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | ICL1 | W | 74 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Van-der-waals | ICL1 | W | 74 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Polar | ICL2 | H | 155 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | H | 155 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | H | 155 | - | G.H5 | N | 348 | G.H5.19 |
Ionic | H8 | R | 364 | 8x55 | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | H8 | R | 364 | 8x55 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | H8 | R | 364 | 8x55 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | H8 | R | 364 | 8x55 | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | ICL1 | W | 74 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | ICL1 | W | 74 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Van-der-waals | ICL1 | W | 74 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | C-term | F | 434 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | F | 434 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | TM6 | K | 290 | 6x30 | G.H5 | I | 345 | G.H5.16 |