GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.7
PAE mean: 25.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | F | 389 | - | H.HA | S | 75 | H.HA.13 |
Van-der-waals | C-term | F | 389 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | C-term | V | 386 | - | H.HA | V | 72 | H.HA.10 |
Polar | TM6 | S | 245 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | S | 245 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | S | 245 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | W | 407 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | W | 407 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | C-term | W | 407 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | W | 407 | - | G.H2 | R | 208 | G.H2.04 |
Ionic | C-term | E | 392 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | C-term | E | 392 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Van-der-waals | C-term | E | 392 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Polar | TM3 | Y | 139 | 3x53 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM3 | Y | 139 | 3x53 | G.H5 | K | 345 | G.H5.17 |
Ionic | C-term | D | 385 | - | G.H1 | K | 51 | G.H1.06 |
Polar | C-term | D | 385 | - | G.H1 | K | 51 | G.H1.06 |
Hydrophobic | C-term | D | 385 | - | G.H1 | K | 51 | G.H1.06 |
Van-der-waals | C-term | D | 385 | - | G.H1 | K | 51 | G.H1.06 |
Hydrophobic | ICL2 | A | 144 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | S | 148 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | P | 404 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | P | 404 | - | G.H2 | K | 209 | G.H2.05 |
Polar | C-term | E | 408 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | E | 408 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | E | 408 | - | G.H3 | S | 252 | G.H3.11 |
Polar | TM6 | N | 238 | 6x23 | G.H5 | A | 338 | G.H5.10 |
Van-der-waals | TM6 | N | 238 | 6x23 | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | C-term | F | 389 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Polar | TM6 | N | 241 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | N | 241 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | N | 241 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | D | 385 | - | H.HA | Y | 69 | H.HA.07 |
Hydrophobic | C-term | D | 385 | - | H.HA | Y | 69 | H.HA.07 |
Van-der-waals | C-term | D | 385 | - | H.HA | Y | 69 | H.HA.07 |
Van-der-waals | C-term | I | 380 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM6 | V | 248 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | V | 248 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Polar | C-term | Q | 388 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Hydrophobic | C-term | Q | 388 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Van-der-waals | C-term | Q | 388 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Aromatic | TM3 | Y | 139 | 3x53 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | Y | 139 | 3x53 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM3 | Y | 139 | 3x53 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | Q | 146 | 34x53 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 146 | 34x53 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | C-term | E | 408 | - | G.H3 | L | 249 | G.H3.08 |
Van-der-waals | C-term | E | 408 | - | G.H3 | L | 249 | G.H3.08 |
Polar | C-term | L | 383 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | C-term | L | 383 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | L | 383 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | C-term | W | 390 | - | H.HA | V | 71 | H.HA.09 |
Van-der-waals | C-term | W | 390 | - | H.HA | V | 71 | H.HA.09 |
Polar | C-term | P | 381 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | P | 381 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | H8 | E | 312 | 8x49 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | E | 312 | 8x49 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM4 | H | 150 | 4x38 | G.HN | R | 24 | G.HN.48 |
Aromatic | TM4 | H | 150 | 4x38 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | H | 150 | 4x38 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | H | 150 | 4x38 | G.HN | R | 24 | G.HN.48 |
Polar | TM6 | N | 241 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | N | 241 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | N | 241 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Polar | TM6 | R | 240 | 6x25 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.S6 | Y | 320 | G.S6.02 |
Ionic | C-term | R | 393 | - | H.hbhc | E | 115 | H.hbhc.03 |
Polar | C-term | R | 393 | - | H.hbhc | E | 115 | H.hbhc.03 |
Hydrophobic | C-term | R | 393 | - | H.hbhc | E | 115 | H.hbhc.03 |
Van-der-waals | C-term | R | 393 | - | H.hbhc | E | 115 | H.hbhc.03 |
Hydrophobic | C-term | D | 403 | - | G.H2 | R | 205 | G.H2.01 |
Van-der-waals | C-term | D | 403 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | Q | 388 | - | G.hfs2 | T | 181 | G.hfs2.05 |
Van-der-waals | C-term | Q | 388 | - | G.hfs2 | T | 181 | G.hfs2.05 |
Hydrophobic | TM3 | V | 135 | 3x49 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | V | 135 | 3x49 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | D | 403 | - | G.H2 | S | 206 | G.H2.02 |
Hydrophobic | C-term | D | 403 | - | G.H2 | S | 206 | G.H2.02 |
Van-der-waals | C-term | D | 403 | - | G.H2 | S | 206 | G.H2.02 |
Hydrophobic | C-term | W | 407 | - | G.H3 | I | 253 | G.H3.12 |
Van-der-waals | C-term | W | 407 | - | G.H3 | I | 253 | G.H3.12 |
Ionic | TM4 | H | 150 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | H | 150 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | H | 150 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | H | 150 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM2 | S | 71 | 2x37 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | S | 71 | 2x37 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | S | 71 | 2x37 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | I | 382 | - | H.HA | Q | 68 | H.HA.06 |
Polar | TM6 | R | 244 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | R | 244 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL2 | Q | 146 | 34x53 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | Q | 146 | 34x53 | G.S3 | L | 194 | G.S3.01 |
Polar | TM6 | N | 241 | 6x26 | G.H5 | V | 342 | G.H5.14 |
Hydrophobic | TM6 | N | 241 | 6x26 | G.H5 | V | 342 | G.H5.14 |
Van-der-waals | TM6 | N | 241 | 6x26 | G.H5 | V | 342 | G.H5.14 |
Polar | TM2 | S | 71 | 2x37 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | S | 71 | 2x37 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | S | 71 | 2x37 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | I | 73 | 2x39 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | I | 73 | 2x39 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | R | 244 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 244 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | A | 144 | 34x51 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | W | 407 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | W | 407 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | W | 407 | - | G.H3 | S | 252 | G.H3.11 |
Polar | ICL1 | K | 69 | - | G.HN | G | 27 | G.HN.51 |
Polar | ICL2 | Q | 146 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 146 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 146 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | F | 389 | - | H.HA | V | 72 | H.HA.10 |
Van-der-waals | H8 | E | 315 | 8x52 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM6 | N | 241 | 6x26 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | N | 241 | 6x26 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | L | 383 | - | H.HA | Y | 69 | H.HA.07 |
Van-der-waals | C-term | L | 383 | - | H.HA | Y | 69 | H.HA.07 |
Hydrophobic | C-term | V | 386 | - | H.HA | Y | 69 | H.HA.07 |
Polar | ICL2 | S | 148 | 34x55 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | S | 148 | 34x55 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | L | 383 | - | H.HA | E | 65 | H.HA.03 |
Polar | C-term | I | 405 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | I | 405 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | I | 405 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | W | 407 | - | G.H3 | N | 256 | G.H3.15 |
Van-der-waals | C-term | W | 407 | - | G.H3 | N | 256 | G.H3.15 |
Hydrophobic | ICL3 | Q | 237 | - | G.H5 | A | 338 | G.H5.10 |
Van-der-waals | ICL3 | Q | 237 | - | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | H8 | E | 315 | 8x52 | G.h4s6 | T | 316 | G.h4s6.10 |
Van-der-waals | H8 | E | 315 | 8x52 | G.h4s6 | T | 316 | G.h4s6.10 |
Polar | TM2 | H | 74 | 2x40 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | H | 74 | 2x40 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | H | 74 | 2x40 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL3 | Q | 237 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | ICL3 | Q | 237 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | Q | 237 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | C-term | P | 404 | - | G.H2 | S | 206 | G.H2.02 |
Van-der-waals | C-term | P | 404 | - | G.H2 | S | 206 | G.H2.02 |
Hydrophobic | TM3 | Y | 139 | 3x53 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | P | 143 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 143 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | N | 238 | 6x23 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | N | 238 | 6x23 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | N | 238 | 6x23 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | Q | 388 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | C-term | Q | 388 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Van-der-waals | C-term | Q | 388 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Polar | ICL3 | Q | 237 | - | G.H5 | Q | 333 | G.H5.05 |
Hydrophobic | TM2 | M | 72 | 2x38 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | Y | 139 | 3x53 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | D | 385 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Van-der-waals | C-term | D | 385 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Ionic | TM6 | R | 240 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 240 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 244 | 6x29 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | ICL2 | A | 144 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | A | 144 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | F | 389 | - | H.HA | V | 71 | H.HA.09 |
Van-der-waals | C-term | F | 389 | - | H.HA | V | 71 | H.HA.09 |
Van-der-waals | ICL1 | K | 69 | - | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | A | 144 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | A | 144 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | I | 380 | - | H.HA | D | 64 | H.HA.02 |
Van-der-waals | C-term | I | 380 | - | H.HA | D | 64 | H.HA.02 |
Hydrophobic | C-term | L | 383 | - | G.h1ha | Y | 61 | G.h1ha.04 |
Hydrophobic | C-term | V | 386 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | ICL1 | P | 70 | - | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL1 | P | 70 | - | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | Y | 139 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | Y | 139 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL3 | Q | 237 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL3 | Q | 237 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | Q | 237 | - | G.H5 | D | 337 | G.H5.09 |
Polar | TM2 | S | 71 | 2x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | S | 71 | 2x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | S | 71 | 2x37 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | R | 240 | 6x25 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL3 | T | 236 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | T | 236 | - | G.H5 | F | 334 | G.H5.06 |