GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 73.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | W | 407 | - | G.H2 | R | 228 | G.H2.01 |
Van-der-waals | C-term | W | 407 | - | G.H2 | R | 228 | G.H2.01 |
Ionic | C-term | D | 385 | - | G.HN | K | 34 | G.HN.51 |
Polar | C-term | D | 385 | - | G.HN | K | 34 | G.HN.51 |
Van-der-waals | C-term | D | 385 | - | G.HN | K | 34 | G.HN.51 |
Polar | TM6 | R | 244 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | C-term | V | 386 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | C-term | V | 386 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | ICL2 | Q | 146 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | Q | 146 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Polar | ICL3 | Q | 237 | - | G.H5 | N | 377 | G.H5.09 |
Polar | TM6 | N | 241 | 6x26 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL2 | P | 143 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | P | 143 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | P | 143 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | C-term | F | 389 | - | G.H5 | M | 386 | G.H5.18 |
Hydrophobic | H8 | E | 312 | 8x49 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | H8 | E | 312 | 8x49 | G.H5 | R | 389 | G.H5.21 |
Polar | TM2 | H | 74 | 2x40 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | H | 74 | 2x40 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | H | 74 | 2x40 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM6 | N | 238 | 6x23 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | N | 238 | 6x23 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | N | 238 | 6x23 | G.H5 | D | 381 | G.H5.13 |
Polar | ICL3 | Q | 237 | - | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | ICL3 | Q | 237 | - | G.S6 | H | 362 | G.S6.04 |
Van-der-waals | ICL3 | Q | 237 | - | G.S6 | H | 362 | G.S6.04 |
Polar | ICL2 | I | 149 | 34x56 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | I | 149 | 34x56 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | V | 147 | 34x54 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | V | 147 | 34x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | W | 390 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Van-der-waals | C-term | W | 390 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Hydrophobic | C-term | R | 393 | - | G.h3s5 | I | 285 | G.h3s5.03 |
Van-der-waals | C-term | R | 393 | - | G.h3s5 | I | 285 | G.h3s5.03 |
Hydrophobic | ICL1 | K | 69 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | K | 69 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | C-term | W | 407 | - | G.H2 | R | 231 | G.H2.04 |
Aromatic | C-term | W | 407 | - | G.H2 | R | 231 | G.H2.04 |
Hydrophobic | C-term | W | 407 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | C-term | W | 407 | - | G.H2 | R | 231 | G.H2.04 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | Q | 146 | 34x53 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | Q | 146 | 34x53 | G.H5 | I | 383 | G.H5.15 |
Ionic | TM2 | H | 74 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Polar | TM2 | H | 74 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | H | 74 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | H | 74 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | R | 240 | 6x25 | G.h4s6 | G | 353 | G.h4s6.09 |
Hydrophobic | C-term | D | 394 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | D | 394 | - | G.H3 | W | 281 | G.H3.17 |
Polar | TM6 | R | 244 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | R | 244 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Polar | C-term | S | 398 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | C-term | S | 398 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | S | 398 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | C-term | F | 389 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | C-term | F | 389 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Ionic | C-term | D | 403 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | C-term | D | 403 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | D | 403 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | TM3 | Y | 139 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM2 | M | 72 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | M | 72 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | V | 396 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | V | 396 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM6 | N | 238 | 6x23 | G.H5 | R | 385 | G.H5.17 |
Polar | C-term | R | 393 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | C-term | R | 393 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | C-term | R | 393 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Polar | C-term | W | 390 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | C-term | W | 390 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | C-term | W | 390 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | ICL2 | Q | 146 | 34x53 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | Q | 146 | 34x53 | G.S1 | H | 41 | G.S1.02 |
Polar | TM1 | N | 64 | 1x60 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM1 | N | 64 | 1x60 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM1 | N | 64 | 1x60 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | A | 144 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | A | 144 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Polar | TM2 | S | 71 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | S | 71 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | S | 71 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Ionic | C-term | D | 403 | - | G.H3 | R | 280 | G.H3.16 |
Polar | C-term | D | 403 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | D | 403 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | D | 403 | - | G.H3 | R | 280 | G.H3.16 |
Polar | H8 | E | 312 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | E | 312 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | E | 312 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | N | 241 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | N | 241 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | N | 241 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | V | 248 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | V | 248 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | TM1 | L | 61 | 1x57 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM1 | L | 61 | 1x57 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | P | 404 | - | G.H3 | S | 275 | G.H3.11 |
Hydrophobic | ICL2 | P | 143 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | TM2 | H | 74 | 2x40 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | H | 74 | 2x40 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | H | 74 | 2x40 | G.H5 | Y | 391 | G.H5.23 |
Ionic | H8 | E | 315 | 8x52 | G.H5 | R | 389 | G.H5.21 |
Polar | H8 | E | 312 | 8x49 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | H8 | E | 312 | 8x49 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | E | 312 | 8x49 | G.H5 | L | 394 | G.H5.26 |
Polar | C-term | V | 386 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | C-term | V | 386 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | C-term | V | 386 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | TM3 | Y | 139 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Polar | TM2 | S | 71 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | S | 71 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | S | 71 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Aromatic | C-term | W | 390 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | C-term | W | 390 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | W | 390 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | TM6 | L | 252 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | R | 244 | 6x29 | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | TM6 | N | 238 | 6x23 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | TM6 | N | 238 | 6x23 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | C-term | W | 407 | - | G.H2 | D | 229 | G.H2.02 |
Polar | TM3 | Y | 139 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | TM3 | Y | 139 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | Y | 139 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | Y | 139 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.h4s6 | Y | 358 | G.h4s6.20 |
Ionic | H8 | E | 315 | 8x52 | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM6 | N | 241 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | N | 241 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | N | 241 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Polar | ICL2 | Q | 146 | 34x53 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM6 | N | 238 | 6x23 | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | TM2 | I | 73 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM2 | I | 73 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | W | 407 | - | G.H2 | R | 232 | G.H2.05 |
Van-der-waals | C-term | W | 407 | - | G.H2 | R | 232 | G.H2.05 |
Polar | C-term | R | 393 | - | G.H3 | W | 281 | G.H3.17 |