GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 25.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | W | 390 | - | G.H3 | F | 255 | G.H3.18 |
Polar | TM6 | R | 244 | 6x29 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | TM6 | R | 244 | 6x29 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.H5 | L | 344 | G.H5.20 |
Polar | TM6 | R | 244 | 6x29 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM6 | R | 244 | 6x29 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | C-term | F | 389 | - | G.H2 | K | 205 | G.H2.05 |
Polar | C-term | R | 393 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | C-term | R | 393 | - | G.H2 | I | 208 | G.H2.08 |
Van-der-waals | C-term | R | 393 | - | G.H2 | I | 208 | G.H2.08 |
Ionic | C-term | D | 385 | - | G.H2 | R | 201 | G.H2.01 |
Polar | C-term | D | 385 | - | G.H2 | R | 201 | G.H2.01 |
Hydrophobic | C-term | D | 385 | - | G.H2 | R | 201 | G.H2.01 |
Van-der-waals | C-term | D | 385 | - | G.H2 | R | 201 | G.H2.01 |
Polar | H8 | E | 312 | 8x49 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | H8 | E | 312 | 8x49 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | E | 312 | 8x49 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | I | 243 | 6x28 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | TM6 | I | 243 | 6x28 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | C-term | V | 386 | - | G.H3 | H | 244 | G.H3.07 |
Polar | ICL3 | T | 236 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Hydrophobic | ICL3 | T | 236 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Van-der-waals | ICL3 | T | 236 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Polar | TM6 | R | 240 | 6x25 | G.S5 | S | 259 | G.S5.01 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.S5 | S | 259 | G.S5.01 |
Polar | TM2 | S | 71 | 2x37 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM2 | S | 71 | 2x37 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM2 | S | 71 | 2x37 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | C-term | L | 383 | - | G.H3 | H | 244 | G.H3.07 |
Van-der-waals | C-term | L | 383 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | TM6 | M | 251 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | F | 389 | - | G.H2 | W | 207 | G.H2.07 |
Hydrophobic | C-term | P | 404 | - | G.H2 | H | 209 | G.H2.09 |
Van-der-waals | C-term | P | 404 | - | G.H2 | H | 209 | G.H2.09 |
Polar | TM6 | N | 241 | 6x26 | G.h3s5 | T | 257 | G.h3s5.02 |
Ionic | C-term | D | 394 | - | G.H3 | R | 253 | G.H3.16 |
Polar | C-term | D | 394 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | C-term | D | 394 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | D | 394 | - | G.H3 | R | 253 | G.H3.16 |
Polar | ICL3 | T | 236 | - | G.h2s4 | G | 213 | G.h2s4.03 |
Hydrophobic | ICL3 | T | 236 | - | G.h2s4 | G | 213 | G.h2s4.03 |
Van-der-waals | ICL3 | T | 236 | - | G.h2s4 | G | 213 | G.h2s4.03 |
Polar | TM6 | N | 238 | 6x23 | G.h3s5 | T | 257 | G.h3s5.02 |
Polar | TM6 | R | 240 | 6x25 | G.h2s4 | T | 215 | G.h2s4.05 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.h2s4 | T | 215 | G.h2s4.05 |
Polar | C-term | R | 393 | - | G.H3 | Y | 254 | G.H3.17 |
Aromatic | C-term | R | 393 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | C-term | R | 393 | - | G.H3 | Y | 254 | G.H3.17 |
Van-der-waals | C-term | R | 393 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | C-term | F | 389 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Van-der-waals | C-term | F | 389 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | H8 | G | 316 | 8x53 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | H8 | S | 310 | 8x47 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | H8 | S | 310 | 8x47 | G.H5 | L | 349 | G.H5.25 |
Polar | TM3 | Y | 139 | 3x53 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM3 | Y | 139 | 3x53 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | H8 | E | 315 | 8x52 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | H8 | E | 315 | 8x52 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | C-term | W | 390 | - | G.H3 | I | 249 | G.H3.12 |
Hydrophobic | TM3 | Y | 139 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | C-term | R | 393 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | C-term | F | 389 | - | G.H2 | R | 204 | G.H2.04 |
Van-der-waals | C-term | F | 389 | - | G.H2 | R | 204 | G.H2.04 |
Ionic | TM6 | R | 240 | 6x25 | G.H5 | D | 346 | G.H5.22 |
Polar | TM6 | R | 240 | 6x25 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.H5 | D | 346 | G.H5.22 |
Polar | TM6 | R | 244 | 6x29 | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | TM6 | R | 244 | 6x29 | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.H5 | K | 345 | G.H5.21 |
Ionic | C-term | D | 403 | - | G.H2 | H | 209 | G.H2.09 |
Polar | C-term | D | 403 | - | G.H2 | H | 209 | G.H2.09 |
Hydrophobic | C-term | P | 404 | - | G.S2 | I | 180 | G.S2.01 |
Ionic | TM5 | K | 230 | 5x66 | G.HN | E | 16 | G.HN.44 |
Polar | TM5 | K | 230 | 5x66 | G.HN | E | 16 | G.HN.44 |
Van-der-waals | TM5 | K | 230 | 5x66 | G.HN | E | 16 | G.HN.44 |
Polar | C-term | W | 407 | - | G.hfs2 | T | 178 | G.hfs2.06 |
Hydrophobic | H8 | E | 312 | 8x49 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | H8 | E | 312 | 8x49 | G.H5 | L | 349 | G.H5.25 |
Polar | C-term | W | 407 | - | G.S2 | I | 180 | G.S2.01 |
Hydrophobic | C-term | W | 407 | - | G.S2 | I | 180 | G.S2.01 |
Van-der-waals | C-term | W | 407 | - | G.S2 | I | 180 | G.S2.01 |
Hydrophobic | ICL3 | Q | 237 | - | G.h2s4 | G | 213 | G.h2s4.03 |
Van-der-waals | ICL3 | Q | 237 | - | G.h2s4 | G | 213 | G.h2s4.03 |
Aromatic | C-term | W | 390 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | C-term | W | 390 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | C-term | W | 390 | - | G.H3 | H | 252 | G.H3.15 |
Polar | TM6 | R | 240 | 6x25 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.H5 | N | 343 | G.H5.19 |
Ionic | ICL1 | K | 69 | - | G.h4s6 | D | 311 | G.h4s6.09 |
Polar | ICL1 | K | 69 | - | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | ICL1 | K | 69 | - | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | H8 | E | 315 | 8x52 | G.H5 | F | 350 | G.H5.26 |
Polar | TM6 | K | 246 | 6x31 | G.HN | A | 23 | G.HN.51 |
Van-der-waals | TM6 | K | 246 | 6x31 | G.HN | A | 23 | G.HN.51 |
Hydrophobic | ICL3 | Q | 237 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Van-der-waals | ICL3 | Q | 237 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Hydrophobic | TM6 | V | 248 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | H8 | E | 311 | 8x48 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | H8 | E | 311 | 8x48 | G.H5 | L | 344 | G.H5.20 |
Ionic | C-term | E | 392 | - | G.H2 | K | 205 | G.H2.05 |
Polar | C-term | E | 392 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | C-term | E | 392 | - | G.H2 | K | 205 | G.H2.05 |
Van-der-waals | C-term | E | 392 | - | G.H2 | K | 205 | G.H2.05 |
Ionic | ICL3 | K | 235 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Polar | ICL3 | K | 235 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Hydrophobic | ICL3 | K | 235 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Van-der-waals | ICL3 | K | 235 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Polar | ICL3 | Q | 237 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Van-der-waals | ICL3 | Q | 237 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Polar | C-term | W | 390 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | W | 390 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | C-term | W | 407 | - | G.S2 | I | 181 | G.S2.02 |
Van-der-waals | C-term | W | 407 | - | G.S2 | I | 181 | G.S2.02 |
Hydrophobic | C-term | W | 390 | - | G.H3 | Y | 254 | G.H3.17 |
Polar | TM6 | R | 244 | 6x29 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM6 | R | 244 | 6x29 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | H8 | F | 313 | 8x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | H8 | F | 313 | 8x50 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM2 | I | 73 | 2x39 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM2 | I | 73 | 2x39 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM6 | R | 244 | 6x29 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM6 | R | 244 | 6x29 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | Q | 146 | 34x53 | G.h3s5 | T | 257 | G.h3s5.02 |
Polar | C-term | P | 381 | - | G.H3 | H | 244 | G.H3.07 |
Van-der-waals | C-term | P | 381 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | TM1 | N | 64 | 1x60 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM1 | N | 64 | 1x60 | G.H5 | F | 350 | G.H5.26 |
Polar | C-term | V | 386 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | C-term | V | 386 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | V | 386 | - | G.H3 | S | 248 | G.H3.11 |
Ionic | TM6 | R | 240 | 6x25 | G.H5 | E | 342 | G.H5.18 |
Polar | TM6 | R | 240 | 6x25 | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.H5 | E | 342 | G.H5.18 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.H5 | E | 342 | G.H5.18 |
Polar | TM6 | N | 241 | 6x26 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM6 | N | 241 | 6x26 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM6 | N | 241 | 6x26 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL3 | Q | 237 | - | G.H3 | Y | 254 | G.H3.17 |
Van-der-waals | ICL3 | Q | 237 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | C-term | F | 389 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | ICL2 | Q | 146 | 34x53 | G.h4s6 | V | 312 | G.h4s6.10 |
Van-der-waals | ICL2 | Q | 146 | 34x53 | G.h4s6 | V | 312 | G.h4s6.10 |
Polar | TM2 | H | 74 | 2x40 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM2 | H | 74 | 2x40 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM2 | H | 74 | 2x40 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | V | 386 | - | G.H3 | L | 245 | G.H3.08 |
Hydrophobic | TM5 | K | 230 | 5x66 | G.HN | L | 19 | G.HN.47 |
Polar | C-term | N | 402 | - | G.H2 | H | 209 | G.H2.09 |
Hydrophobic | C-term | N | 402 | - | G.H2 | H | 209 | G.H2.09 |
Hydrophobic | TM2 | I | 77 | 2x43 | G.H5 | L | 349 | G.H5.25 |
Polar | TM2 | H | 74 | 2x40 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM2 | H | 74 | 2x40 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM2 | H | 74 | 2x40 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | E | 312 | 8x49 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | TM6 | V | 248 | 6x33 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM6 | V | 248 | 6x33 | G.H5 | C | 347 | G.H5.23 |
Polar | TM6 | R | 240 | 6x25 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | C-term | W | 390 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Van-der-waals | C-term | W | 390 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | TM6 | I | 243 | 6x28 | G.hns1 | D | 26 | G.hns1.01 |
Van-der-waals | TM6 | I | 243 | 6x28 | G.hns1 | D | 26 | G.hns1.01 |