GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | I | 365 | - | G.S2 | H | 188 | G.S2.05 |
Van-der-waals | C-term | I | 365 | - | G.S2 | H | 188 | G.S2.05 |
Polar | TM6 | N | 264 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | N | 264 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | N | 264 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | V | 214 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | L | 466 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | V | 129 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 129 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | V | 222 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | V | 222 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Ionic | TM5 | H | 223 | 5x73 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM5 | H | 223 | 5x73 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | L | 478 | - | G.H3 | K | 248 | G.H3.07 |
Hydrophobic | TM5 | I | 211 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | I | 211 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | V | 222 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | V | 222 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Polar | TM6 | T | 271 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | T | 271 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | T | 271 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | I | 272 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | M | 133 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | C-term | I | 361 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | ICL2 | P | 136 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | L | 368 | - | G.S2 | E | 186 | G.S2.03 |
Van-der-waals | C-term | L | 368 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | TM5 | I | 211 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | R | 354 | - | G.HN | G | 27 | G.HN.51 |
Hydrophobic | C-term | R | 354 | - | G.HN | G | 27 | G.HN.51 |
Van-der-waals | C-term | R | 354 | - | G.HN | G | 27 | G.HN.51 |
Hydrophobic | TM5 | A | 215 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | R | 354 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | C-term | R | 354 | - | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | C-term | R | 354 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | TM5 | K | 218 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | K | 218 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.S3 | F | 196 | G.S3.03 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | M | 133 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM3 | V | 129 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | P | 136 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | P | 136 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 132 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | M | 137 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | M | 137 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | C-term | Q | 353 | - | G.HN | L | 23 | G.HN.47 |
Polar | TM6 | K | 267 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 267 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 267 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.S2 | F | 191 | G.S2.08 |
Hydrophobic | C-term | P | 348 | - | G.H3 | W | 258 | G.H3.17 |
Van-der-waals | C-term | P | 348 | - | G.H3 | W | 258 | G.H3.17 |
Polar | TM3 | R | 125 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 125 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 125 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | I | 365 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | C-term | L | 368 | - | G.S2 | V | 185 | G.S2.02 |
Polar | ICL3 | Q | 257 | - | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | ICL3 | Q | 257 | - | G.H4 | E | 308 | G.H4.16 |
Ionic | TM5 | K | 218 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | K | 218 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | K | 218 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | K | 218 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Ionic | TM5 | K | 221 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Polar | TM5 | K | 221 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | K | 221 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL2 | P | 132 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 132 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Ionic | C-term | R | 357 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | R | 357 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | R | 357 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | TM6 | T | 271 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Ionic | C-term | R | 352 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Polar | C-term | R | 352 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | R | 352 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | R | 352 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Polar | ICL1 | S | 56 | 12x48 | G.HN | D | 20 | G.HN.44 |
Hydrophobic | ICL1 | S | 56 | 12x48 | G.HN | D | 20 | G.HN.44 |
Van-der-waals | ICL1 | S | 56 | 12x48 | G.HN | D | 20 | G.HN.44 |
Ionic | TM2 | K | 64 | 2x41 | G.HN | E | 28 | G.HN.52 |
Polar | TM2 | K | 64 | 2x41 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM2 | K | 64 | 2x41 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | A | 467 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | A | 467 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | M | 133 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | T | 355 | - | G.HN | I | 19 | G.HN.43 |
Ionic | ICL3 | R | 253 | - | G.H4 | D | 309 | G.H4.17 |
Polar | ICL3 | R | 253 | - | G.H4 | D | 309 | G.H4.17 |
Van-der-waals | ICL3 | R | 253 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | ICL2 | M | 133 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | M | 133 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | TM3 | A | 128 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 128 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 128 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | L | 358 | - | G.HN | D | 26 | G.HN.50 |
Van-der-waals | C-term | L | 358 | - | G.HN | D | 26 | G.HN.50 |
Polar | TM4 | G | 141 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | G | 141 | 4x39 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | G | 141 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | L | 377 | - | H.hbhc | E | 116 | H.hbhc.04 |
Polar | C-term | R | 354 | - | G.HN | D | 26 | G.HN.50 |
Hydrophobic | C-term | R | 354 | - | G.HN | D | 26 | G.HN.50 |
Van-der-waals | C-term | R | 354 | - | G.HN | D | 26 | G.HN.50 |
Hydrophobic | ICL2 | M | 137 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | M | 137 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | H8 | N | 328 | 8x47 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | H8 | N | 328 | 8x47 | G.H5 | E | 350 | G.H5.22 |
Polar | TM6 | A | 268 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | H8 | K | 329 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | K | 329 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | K | 329 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | L | 368 | - | G.S2 | H | 188 | G.S2.05 |
Hydrophobic | C-term | R | 354 | - | G.HN | L | 23 | G.HN.47 |
Van-der-waals | C-term | R | 354 | - | G.HN | L | 23 | G.HN.47 |
Hydrophobic | ICL2 | P | 136 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | P | 136 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | V | 350 | - | G.H3 | W | 258 | G.H3.17 |
Van-der-waals | C-term | V | 350 | - | G.H3 | W | 258 | G.H3.17 |
Hydrophobic | C-term | T | 355 | - | G.HN | L | 23 | G.HN.47 |