GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 66.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 18.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | F | 482 | - | G.H3 | N | 270 | G.H3.07 |
Hydrophobic | C-term | F | 508 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | F | 508 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | C-term | L | 479 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | L | 479 | - | G.H3 | T | 274 | G.H3.11 |
Ionic | ICL3 | D | 258 | - | G.H4 | R | 331 | G.H4.16 |
Polar | ICL3 | D | 258 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL3 | D | 258 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | D | 258 | - | G.H4 | R | 331 | G.H4.16 |
Polar | ICL3 | S | 256 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL3 | S | 256 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | S | 256 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | C-term | L | 479 | - | G.H3 | N | 278 | G.H3.15 |
Van-der-waals | C-term | L | 479 | - | G.H3 | N | 278 | G.H3.15 |
Polar | C-term | E | 484 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | E | 484 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | E | 484 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | TM3 | M | 118 | 3x53 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | H8 | R | 329 | 8x49 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | R | 329 | 8x49 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | I | 509 | - | G.s3h2 | Q | 226 | G.s3h2.03 |
Ionic | C-term | E | 511 | - | H.hbhc | R | 128 | H.hbhc.01 |
Polar | C-term | E | 511 | - | H.hbhc | R | 128 | H.hbhc.01 |
Van-der-waals | C-term | E | 511 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | C-term | I | 505 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | ICL2 | L | 127 | 34x55 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL3 | S | 255 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | S | 255 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL2 | V | 123 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | Y | 125 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | M | 118 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | M | 118 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Polar | H8 | R | 329 | 8x49 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | H8 | R | 329 | 8x49 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | C-term | L | 476 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | C-term | I | 505 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | I | 505 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Polar | C-term | P | 513 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | P | 513 | - | H.HA | K | 105 | H.HA.28 |
Ionic | C-term | E | 504 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | C-term | E | 504 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | E | 504 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | E | 504 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Polar | C-term | G | 475 | - | G.H3 | N | 278 | G.H3.15 |
Van-der-waals | C-term | G | 475 | - | G.H3 | N | 278 | G.H3.15 |
Polar | TM2 | K | 46 | 2x38 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | K | 46 | 2x38 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | K | 46 | 2x38 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM6 | T | 265 | 6x28 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | T | 265 | 6x28 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | I | 505 | - | G.s3h2 | Q | 226 | G.s3h2.03 |
Hydrophobic | C-term | P | 515 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | P | 515 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | ICL2 | R | 126 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | R | 126 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | V | 123 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | V | 123 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | C-term | L | 479 | - | G.H3 | F | 281 | G.H3.18 |
Hydrophobic | TM6 | Q | 268 | 6x31 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | Q | 268 | 6x31 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | R | 126 | 34x54 | G.H5 | N | 370 | G.H5.19 |
Polar | C-term | A | 471 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | I | 509 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | I | 509 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Polar | TM3 | R | 120 | 3x55 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | TM3 | R | 120 | 3x55 | G.H5 | K | 363 | G.H5.12 |
Polar | ICL3 | R | 254 | - | G.HG | T | 293 | G.HG.01 |
Hydrophobic | ICL3 | R | 254 | - | G.HG | T | 293 | G.HG.01 |
Van-der-waals | ICL3 | R | 254 | - | G.HG | T | 293 | G.HG.01 |
Polar | C-term | L | 514 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | L | 514 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | ICL3 | R | 254 | - | G.H4 | Q | 323 | G.H4.08 |
Hydrophobic | ICL2 | V | 123 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL3 | A | 216 | - | G.H5 | R | 360 | G.H5.09 |
Polar | ICL2 | R | 126 | 34x54 | G.h2s4 | T | 241 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 126 | 34x54 | G.h2s4 | T | 241 | G.h2s4.05 |
Polar | TM1 | K | 41 | 1x60 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM1 | K | 41 | 1x60 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM1 | K | 41 | 1x60 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | F | 508 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | F | 508 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | ICL3 | L | 257 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | ICL3 | L | 257 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | ICL3 | R | 254 | - | G.S6 | H | 345 | G.S6.04 |
Van-der-waals | ICL3 | R | 254 | - | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | C-term | L | 483 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Hydrophobic | ICL3 | D | 258 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | ICL3 | D | 258 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | C-term | L | 479 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Van-der-waals | C-term | L | 479 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Hydrophobic | C-term | F | 482 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | F | 482 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | C-term | L | 479 | - | G.H2 | F | 234 | G.H2.08 |
Van-der-waals | C-term | L | 479 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | C-term | I | 509 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Van-der-waals | C-term | I | 509 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Polar | ICL3 | D | 258 | - | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | ICL3 | D | 258 | - | G.S6 | L | 342 | G.S6.01 |
Van-der-waals | ICL3 | D | 258 | - | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | C-term | E | 511 | - | H.HB | T | 127 | H.HB.14 |
Hydrophobic | C-term | P | 513 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | P | 513 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | L | 483 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | L | 483 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | TM6 | V | 269 | 6x32 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM6 | V | 269 | 6x32 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL2 | P | 122 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Polar | ICL3 | R | 254 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | ICL3 | R | 254 | - | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | ICL3 | R | 254 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | C-term | T | 512 | - | H.HA | R | 97 | H.HA.20 |
Van-der-waals | C-term | T | 512 | - | H.HA | R | 97 | H.HA.20 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM6 | T | 265 | 6x28 | G.H5 | L | 371 | G.H5.20 |
Ionic | ICL2 | R | 126 | 34x54 | G.H5 | D | 369 | G.H5.18 |
Polar | ICL2 | R | 126 | 34x54 | G.H5 | D | 369 | G.H5.18 |
Van-der-waals | ICL2 | R | 126 | 34x54 | G.H5 | D | 369 | G.H5.18 |
Hydrophobic | C-term | R | 447 | - | G.HN | L | 5 | G.HN.05 |
Polar | C-term | I | 509 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | C-term | I | 509 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | I | 509 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | ICL2 | R | 126 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Polar | C-term | S | 516 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | ICL2 | V | 123 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | TM3 | M | 118 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | M | 118 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | I | 505 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Van-der-waals | C-term | I | 505 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Hydrophobic | TM5 | R | 209 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | R | 209 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | L | 476 | - | G.H3 | V | 280 | G.H3.17 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | L | 371 | G.H5.20 |
Ionic | C-term | D | 510 | - | H.HA | K | 94 | H.HA.17 |
Polar | C-term | D | 510 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | C-term | D | 510 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | D | 510 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | F | 508 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | F | 508 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Polar | H8 | R | 329 | 8x49 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | H8 | R | 329 | 8x49 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | H8 | R | 329 | 8x49 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL3 | G | 259 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | ICL1 | Q | 42 | 12x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL1 | Q | 42 | 12x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL1 | Q | 42 | 12x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | T | 512 | - | H.HB | M | 123 | H.HB.10 |
Aromatic | C-term | R | 480 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | C-term | R | 480 | - | G.H2 | F | 234 | G.H2.08 |
Van-der-waals | C-term | R | 480 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | TM2 | K | 46 | 2x38 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | V | 269 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | V | 269 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | A | 448 | - | G.HN | L | 5 | G.HN.05 |
Van-der-waals | C-term | A | 448 | - | G.HN | L | 5 | G.HN.05 |
Hydrophobic | ICL2 | L | 127 | 34x55 | G.S3 | P | 217 | G.S3.02 |
Hydrophobic | ICL3 | S | 255 | - | G.S6 | H | 345 | G.S6.04 |
Van-der-waals | ICL3 | S | 255 | - | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | C-term | F | 500 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | F | 500 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | TM2 | L | 48 | 2x40 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | D | 510 | - | H.HB | T | 127 | H.HB.14 |
Hydrophobic | TM6 | S | 266 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | S | 266 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | L | 483 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | L | 483 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | L | 483 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | F | 500 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Van-der-waals | C-term | F | 500 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Hydrophobic | C-term | L | 483 | - | G.H2 | W | 233 | G.H2.07 |
Polar | TM6 | S | 262 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | S | 262 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | S | 262 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | C-term | P | 513 | - | H.HA | V | 98 | H.HA.21 |
Polar | H8 | R | 329 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | R | 329 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | R | 329 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | D | 510 | - | H.hbhc | G | 135 | H.hbhc.08 |
Hydrophobic | C-term | V | 406 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Van-der-waals | C-term | V | 406 | - | G.h1ha | Q | 74 | G.h1ha.02 |
Ionic | ICL3 | R | 254 | - | G.HG | E | 297 | G.HG.05 |
Polar | ICL3 | R | 254 | - | G.HG | E | 297 | G.HG.05 |
Hydrophobic | ICL3 | R | 254 | - | G.HG | E | 297 | G.HG.05 |
Van-der-waals | ICL3 | R | 254 | - | G.HG | E | 297 | G.HG.05 |
Polar | ICL2 | L | 127 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | L | 127 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | L | 127 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | L | 127 | 34x55 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | C-term | L | 483 | - | G.H2 | F | 234 | G.H2.08 |
Van-der-waals | C-term | L | 483 | - | G.H2 | F | 234 | G.H2.08 |
Ionic | C-term | D | 510 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Hydrophobic | C-term | D | 510 | - | H.hbhc | A | 133 | H.hbhc.06 |