GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 68.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 14.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | R | 209 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | R | 209 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | L | 127 | 34x55 | G.S3 | V | 199 | G.S3.01 |
Ionic | C-term | D | 415 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | ICL2 | L | 127 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | L | 127 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | R | 126 | 34x54 | G.H5 | L | 351 | G.H5.18 |
Van-der-waals | ICL2 | R | 126 | 34x54 | G.H5 | L | 351 | G.H5.18 |
Polar | H8 | R | 329 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | H8 | R | 329 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | L | 388 | - | G.H3 | A | 253 | G.H3.07 |
Hydrophobic | C-term | L | 404 | - | G.H2 | H | 218 | G.H2.09 |
Hydrophobic | C-term | L | 388 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | TM6 | V | 269 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | T | 265 | 6x28 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | T | 265 | 6x28 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | V | 123 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL2 | Y | 125 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL3 | G | 222 | - | G.S6 | F | 328 | G.S6.05 |
Hydrophobic | ICL2 | L | 127 | 34x55 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL3 | S | 256 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | S | 256 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | ICL2 | V | 123 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Van-der-waals | ICL2 | V | 123 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | C-term | F | 395 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Van-der-waals | C-term | F | 395 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Polar | TM3 | R | 115 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Polar | H8 | Y | 330 | 8x50 | G.H5 | N | 357 | G.H5.24 |
Polar | H8 | R | 329 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | R | 329 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | R | 329 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Polar | TM6 | S | 262 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | S | 262 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | S | 262 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | Q | 268 | 6x31 | G.H5 | V | 359 | G.H5.26 |
Ionic | TM5 | R | 209 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Polar | TM5 | R | 209 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | R | 209 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL2 | L | 127 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | TM6 | L | 272 | 6x35 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | L | 272 | 6x35 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | F | 395 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | F | 395 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | TM3 | M | 118 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM2 | K | 46 | 2x38 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | K | 46 | 2x38 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Polar | TM3 | R | 120 | 3x55 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | TM3 | R | 120 | 3x55 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM6 | V | 269 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | V | 269 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL3 | L | 257 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL2 | V | 123 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | V | 123 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Polar | TM2 | K | 46 | 2x38 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | K | 46 | 2x38 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | K | 46 | 2x38 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Aromatic | ICL2 | Y | 125 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | Y | 125 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | Y | 125 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL2 | P | 122 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM5 | R | 209 | 5x68 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | R | 209 | 5x68 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | L | 394 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | L | 394 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | TM6 | V | 273 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | V | 273 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | L | 394 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | L | 394 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | TM3 | M | 118 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | M | 118 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM5 | R | 209 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM5 | R | 209 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Polar | ICL3 | S | 256 | - | G.S6 | I | 324 | G.S6.01 |
Van-der-waals | ICL3 | S | 256 | - | G.S6 | I | 324 | G.S6.01 |
Hydrophobic | ICL3 | G | 220 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | ICL2 | R | 126 | 34x54 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | R | 126 | 34x54 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM3 | M | 118 | 3x53 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | M | 118 | 3x53 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL3 | G | 259 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | G | 259 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | C-term | L | 388 | - | G.H3 | E | 250 | G.H3.04 |
Hydrophobic | H8 | Y | 330 | 8x50 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | Y | 330 | 8x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | R | 126 | 34x54 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | C-term | V | 385 | - | G.H3 | R | 256 | G.H3.10 |
Van-der-waals | C-term | V | 385 | - | G.H3 | R | 256 | G.H3.10 |
Hydrophobic | TM2 | L | 48 | 2x40 | G.H5 | L | 358 | G.H5.25 |
Polar | H8 | R | 329 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | R | 329 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | R | 329 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | R | 329 | 8x49 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | R | 329 | 8x49 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | L | 48 | 2x40 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | F | 369 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Van-der-waals | C-term | F | 369 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | TM6 | V | 269 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | V | 269 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | S | 266 | 6x29 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | S | 266 | 6x29 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL3 | L | 257 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | L | 257 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM2 | L | 52 | 2x44 | G.H5 | L | 358 | G.H5.25 |
Polar | H8 | R | 329 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Aromatic | C-term | F | 395 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | F | 395 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | F | 395 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM2 | P | 47 | 2x39 | G.H5 | Y | 356 | G.H5.23 |