GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | L | 116 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | L | 116 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL1 | H | 46 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | ICL1 | H | 46 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Van-der-waals | ICL1 | H | 46 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Ionic | TM1 | K | 42 | 1x60 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | TM1 | K | 42 | 1x60 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | TM6 | N | 217 | 6x29 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | N | 217 | 6x29 | G.H5 | L | 349 | G.H5.20 |
Polar | TM3 | R | 112 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 112 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 112 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Polar | TM3 | H | 118 | 3x56 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM3 | H | 118 | 3x56 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | TM3 | H | 118 | 3x56 | G.hns1 | R | 34 | G.hns1.03 |
Polar | TM3 | T | 117 | 3x55 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | TM3 | T | 117 | 3x55 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM6 | N | 217 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | N | 217 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Ionic | TM5 | R | 204 | 5x63 | G.HN | D | 28 | G.HN.50 |
Polar | TM5 | R | 204 | 5x63 | G.HN | D | 28 | G.HN.50 |
Van-der-waals | TM5 | R | 204 | 5x63 | G.HN | D | 28 | G.HN.50 |
Polar | ICL2 | C | 120 | 34x51 | G.S1 | E | 35 | G.S1.01 |
Hydrophobic | ICL2 | C | 120 | 34x51 | G.S1 | E | 35 | G.S1.01 |
Van-der-waals | ICL2 | C | 120 | 34x51 | G.S1 | E | 35 | G.S1.01 |
Hydrophobic | TM3 | R | 112 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 112 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | H8 | S | 289 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | H8 | S | 289 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | S | 289 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Polar | ICL2 | C | 120 | 34x51 | G.S3 | R | 198 | G.S3.04 |
Hydrophobic | ICL2 | C | 120 | 34x51 | G.S3 | R | 198 | G.S3.04 |
Van-der-waals | ICL2 | C | 120 | 34x51 | G.S3 | R | 198 | G.S3.04 |
Ionic | TM2 | R | 47 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Polar | TM2 | R | 47 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | R | 47 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | R | 47 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM6 | N | 217 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | N | 217 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM6 | N | 214 | 6x26 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | N | 214 | 6x26 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | T | 117 | 3x55 | G.hns1 | A | 32 | G.hns1.01 |
Van-der-waals | TM3 | T | 117 | 3x55 | G.hns1 | A | 32 | G.hns1.01 |
Polar | ICL2 | Y | 123 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | ICL2 | Y | 123 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | Y | 123 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Polar | TM7 | L | 288 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM7 | L | 288 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | L | 288 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Polar | H8 | K | 290 | 8x48 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | H8 | K | 290 | 8x48 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | K | 290 | 8x48 | G.H5 | N | 353 | G.H5.24 |
Polar | ICL2 | Q | 126 | 34x57 | G.hns1 | R | 34 | G.hns1.03 |
Polar | TM3 | Q | 115 | 3x53 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM3 | Q | 115 | 3x53 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | TM3 | Q | 115 | 3x53 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | TM2 | R | 47 | 2x37 | G.h3s5 | N | 262 | G.h3s5.02 |
Polar | ICL3 | N | 212 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | ICL3 | N | 212 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL3 | N | 212 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Polar | TM3 | R | 112 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM3 | R | 112 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 112 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Polar | TM4 | E | 127 | 4x38 | G.h2s4 | S | 218 | G.h2s4.03 |
Van-der-waals | TM4 | E | 127 | 4x38 | G.h2s4 | S | 218 | G.h2s4.03 |
Polar | TM3 | T | 117 | 3x55 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM3 | H | 118 | 3x56 | G.hns1 | R | 33 | G.hns1.02 |
Polar | TM6 | K | 220 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 220 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 220 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | ICL1 | H | 46 | - | G.h3s5 | L | 261 | G.h3s5.01 |
Van-der-waals | ICL1 | H | 46 | - | G.h3s5 | L | 261 | G.h3s5.01 |
Hydrophobic | TM3 | H | 118 | 3x56 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | H | 118 | 3x56 | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | TM3 | H | 118 | 3x56 | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | TM6 | A | 221 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | A | 221 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | S | 119 | 34x50 | G.HN | D | 31 | G.HN.53 |
Van-der-waals | ICL2 | S | 119 | 34x50 | G.HN | D | 31 | G.HN.53 |
Polar | TM5 | R | 208 | 5x67 | G.HN | L | 25 | G.HN.47 |
Hydrophobic | TM5 | R | 208 | 5x67 | G.HN | L | 25 | G.HN.47 |
Polar | ICL2 | S | 119 | 34x50 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | S | 119 | 34x50 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | S | 119 | 34x50 | G.hns1 | R | 33 | G.hns1.02 |
Ionic | TM5 | R | 208 | 5x67 | G.HN | D | 28 | G.HN.50 |
Polar | TM5 | R | 208 | 5x67 | G.HN | D | 28 | G.HN.50 |
Hydrophobic | TM5 | R | 208 | 5x67 | G.HN | D | 28 | G.HN.50 |
Van-der-waals | TM5 | R | 208 | 5x67 | G.HN | D | 28 | G.HN.50 |
Polar | ICL2 | Y | 123 | 34x54 | G.h2s4 | S | 218 | G.h2s4.03 |
Hydrophobic | ICL2 | Y | 123 | 34x54 | G.h2s4 | S | 218 | G.h2s4.03 |
Van-der-waals | ICL2 | Y | 123 | 34x54 | G.h2s4 | S | 218 | G.h2s4.03 |
Hydrophobic | TM6 | K | 220 | 6x32 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | K | 220 | 6x32 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | Q | 115 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | Q | 115 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Polar | TM3 | H | 118 | 3x56 | G.S1 | E | 35 | G.S1.01 |
Van-der-waals | TM3 | H | 118 | 3x56 | G.S1 | E | 35 | G.S1.01 |
Polar | TM6 | K | 220 | 6x32 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM6 | K | 220 | 6x32 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM6 | K | 220 | 6x32 | G.H5 | N | 353 | G.H5.24 |
Polar | TM6 | N | 224 | 6x36 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | S | 119 | 34x50 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM3 | Q | 115 | 3x53 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | Y | 123 | 34x54 | G.h2s4 | V | 219 | G.h2s4.04 |
Hydrophobic | ICL2 | Y | 123 | 34x54 | G.h2s4 | V | 219 | G.h2s4.04 |
Van-der-waals | ICL2 | Y | 123 | 34x54 | G.h2s4 | V | 219 | G.h2s4.04 |
Polar | TM7 | H | 287 | 7x55 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | S | 119 | 34x50 | G.S1 | E | 35 | G.S1.01 |