GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM2 | C | 48 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | C | 48 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | C | 48 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM2 | R | 47 | 2x37 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM2 | R | 47 | 2x37 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM2 | R | 47 | 2x37 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | R | 112 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | R | 112 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | N | 217 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Polar | TM2 | V | 49 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | V | 49 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | V | 49 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | T | 117 | 3x55 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | T | 117 | 3x55 | G.H5 | Q | 384 | G.H5.16 |
Aromatic | ICL2 | Y | 123 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | Y | 123 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | Y | 123 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Polar | ICL1 | N | 45 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL1 | N | 45 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL1 | N | 45 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | Y | 123 | 34x54 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM7 | L | 288 | 7x56 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM7 | L | 288 | 7x56 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | L | 116 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM3 | H | 118 | 3x56 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | H | 118 | 3x56 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | H | 118 | 3x56 | G.H5 | Q | 384 | G.H5.16 |
Polar | H8 | S | 289 | 8x47 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | H8 | S | 289 | 8x47 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | H8 | S | 289 | 8x47 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | TM2 | R | 47 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | R | 47 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | R | 47 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | Q | 126 | 34x57 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | Q | 126 | 34x57 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | L | 116 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Ionic | H8 | K | 290 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | K | 290 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | K | 290 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | K | 290 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | Q | 115 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | Q | 115 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | H8 | K | 290 | 8x48 | G.H5 | Q | 390 | G.H5.22 |
Ionic | TM3 | H | 118 | 3x56 | G.H5 | D | 381 | G.H5.13 |
Polar | TM3 | H | 118 | 3x56 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM3 | H | 118 | 3x56 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM3 | H | 118 | 3x56 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | H8 | S | 289 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | S | 119 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | S | 119 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | TM3 | Q | 115 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM3 | Q | 115 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | Q | 115 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Ionic | ICL2 | K | 121 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | ICL2 | K | 121 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | ICL2 | K | 121 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL2 | K | 121 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | TM2 | R | 47 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | R | 47 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | R | 47 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Ionic | H8 | R | 293 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | R | 293 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | R | 293 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | R | 293 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL2 | C | 120 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | C | 120 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | C | 120 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Polar | TM3 | H | 118 | 3x56 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM3 | H | 118 | 3x56 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM3 | H | 118 | 3x56 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | Y | 123 | 34x54 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | Y | 123 | 34x54 | G.H5 | I | 383 | G.H5.15 |
Polar | H8 | K | 290 | 8x48 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | H8 | K | 290 | 8x48 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | H8 | K | 290 | 8x48 | G.H5 | Y | 391 | G.H5.23 |
Polar | C-term | A | 319 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | A | 319 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | ICL2 | C | 120 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Polar | ICL2 | R | 124 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 124 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | TM3 | Q | 115 | 3x53 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | Q | 115 | 3x53 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | Q | 115 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Polar | TM3 | Q | 115 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | Q | 115 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | Q | 115 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | D | 111 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 111 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM6 | K | 220 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | Q | 126 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Q | 126 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | C | 120 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | C | 120 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM2 | V | 49 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Ionic | TM6 | K | 220 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | K | 220 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | K | 220 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | K | 220 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Ionic | C-term | E | 316 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | C-term | E | 316 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | C-term | E | 316 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | E | 316 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM3 | L | 114 | 3x52 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | L | 114 | 3x52 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | L | 114 | 3x52 | G.H5 | Q | 384 | G.H5.16 |