Gi2 - GPR174 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 82.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 R 53 - G.H5 N 347 G.H5.18
Hydrophobic ICL2 F 124 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 R 116 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 Y 122 3x56 G.HN E 28 G.HN.52
Hydrophobic ICL3 M 218 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 M 218 - G.H5 D 342 G.H5.13
Polar ICL2 R 125 34x52 G.HN G 27 G.HN.51
Hydrophobic ICL2 R 125 34x52 G.HN G 27 G.HN.51
Van-der-waals ICL2 R 125 34x52 G.HN G 27 G.HN.51
Hydrophobic ICL2 F 124 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 F 124 34x51 G.S1 V 34 G.S1.02
Ionic TM6 E 224 6x29 G.H5 K 346 G.H5.17
Polar TM6 E 224 6x29 G.H5 K 346 G.H5.17
Hydrophobic TM6 E 224 6x29 G.H5 K 346 G.H5.17
Van-der-waals TM6 E 224 6x29 G.H5 K 346 G.H5.17
Hydrophobic ICL3 M 218 - G.H5 D 338 G.H5.09
Van-der-waals ICL3 M 218 - G.H5 D 338 G.H5.09
Hydrophobic TM6 M 231 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 M 231 6x36 G.H5 G 353 G.H5.24
Ionic ICL2 R 125 34x52 G.HN E 28 G.HN.52
Polar ICL2 R 125 34x52 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 125 34x52 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 125 34x52 G.HN E 28 G.HN.52
Hydrophobic ICL2 F 124 34x51 G.H5 I 345 G.H5.16
Ionic H8 R 305 8x56 G.h4s6 D 316 G.h4s6.09
Polar H8 R 305 8x56 G.h4s6 D 316 G.h4s6.09
Hydrophobic H8 R 305 8x56 G.h4s6 D 316 G.h4s6.09
Van-der-waals H8 R 305 8x56 G.h4s6 D 316 G.h4s6.09
Polar TM3 M 121 3x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 228 6x33 G.H5 F 355 G.H5.26
Ionic ICL1 R 53 - G.H5 D 351 G.H5.22
Polar ICL1 R 53 - G.H5 D 351 G.H5.22
Hydrophobic ICL1 R 53 - G.H5 D 351 G.H5.22
Van-der-waals ICL1 R 53 - G.H5 D 351 G.H5.22
Hydrophobic TM3 L 120 3x54 G.H5 L 349 G.H5.20
Polar ICL2 F 124 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 F 124 34x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 F 124 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 I 232 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 232 6x37 G.H5 L 354 G.H5.25
Polar ICL2 R 125 34x52 G.HN R 24 G.HN.48
Polar TM3 R 116 3x50 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 123 34x50 G.H5 N 348 G.H5.19
Ionic ICL3 K 215 - G.s2s3 D 194 G.s2s3.02
Polar ICL3 K 215 - G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL3 K 215 - G.s2s3 D 194 G.s2s3.02
Polar H8 N 297 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 N 297 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 N 297 8x48 G.H5 F 355 G.H5.26
Hydrophobic TM6 M 231 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 231 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM3 Y 122 3x56 G.hns1 R 32 G.hns1.03
Van-der-waals TM3 Y 122 3x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 124 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 124 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 F 124 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 124 34x51 G.S3 L 195 G.S3.01
Polar H8 R 301 8x52 G.h4s6 D 316 G.h4s6.09
Hydrophobic H8 R 301 8x52 G.h4s6 D 316 G.h4s6.09
Van-der-waals H8 R 301 8x52 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM3 F 119 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 F 119 3x53 G.H5 C 352 G.H5.23
Polar ICL2 R 125 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 125 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 125 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 E 224 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 E 224 6x29 G.H5 F 355 G.H5.26
Hydrophobic ICL2 F 124 34x51 G.S1 E 33 G.S1.01
Van-der-waals ICL2 F 124 34x51 G.S1 E 33 G.S1.01
Polar H8 R 301 8x52 G.h4s6 T 317 G.h4s6.10
Hydrophobic H8 R 301 8x52 G.h4s6 T 317 G.h4s6.10
Polar TM3 R 116 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM3 R 116 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 116 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM3 L 120 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL3 Y 216 - G.H5 I 345 G.H5.16
Van-der-waals ICL3 Y 216 - G.H5 I 345 G.H5.16
Hydrophobic ICL2 F 124 34x51 G.H5 N 348 G.H5.19
Van-der-waals ICL2 F 124 34x51 G.H5 N 348 G.H5.19
Hydrophobic ICL2 F 124 34x51 G.h2s4 T 220 G.h2s4.05
Van-der-waals ICL2 F 124 34x51 G.h2s4 T 220 G.h2s4.05
Hydrophobic ICL3 M 218 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL3 M 218 - G.s2s3 K 193 G.s2s3.01
Hydrophobic H8 T 296 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM3 F 119 3x53 G.H5 L 349 G.H5.20
Hydrophobic TM2 M 58 2x43 G.H5 G 353 G.H5.24
Hydrophobic TM3 Y 122 3x56 G.hns1 A 31 G.hns1.02