GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 66.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Van-der-waals | C-term | I | 487 | - | G.H2 | K | 213 | G.H2.01 |
Ionic | TM5 | K | 239 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | K | 239 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | K | 239 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | K | 239 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | P | 483 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | P | 483 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | TM2 | T | 76 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | P | 149 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 149 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | L | 150 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | L | 150 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | V | 507 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | V | 507 | - | G.S2 | E | 194 | G.S2.03 |
Polar | ICL3 | Q | 249 | - | G.H4 | E | 306 | G.H4.05 |
Hydrophobic | C-term | F | 510 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | F | 510 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | TM6 | I | 254 | 6x23 | G.H5 | D | 361 | G.H5.13 |
Polar | TM3 | D | 141 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | D | 141 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM6 | L | 264 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | L | 264 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | L | 264 | 6x33 | G.H5 | I | 371 | G.H5.23 |
Polar | H8 | S | 326 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | S | 326 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | S | 326 | 8x49 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | K | 506 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | K | 506 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | ICL2 | P | 149 | - | G.H5 | L | 364 | G.H5.16 |
Aromatic | C-term | F | 510 | - | G.S2 | F | 197 | G.S2.06 |
Hydrophobic | C-term | F | 510 | - | G.S2 | F | 197 | G.S2.06 |
Van-der-waals | C-term | F | 510 | - | G.S2 | F | 197 | G.S2.06 |
Hydrophobic | C-term | V | 513 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | V | 513 | - | G.H1 | H | 66 | G.H1.12 |
Polar | C-term | T | 489 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | T | 489 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | T | 489 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | C-term | I | 487 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | I | 487 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | H8 | N | 324 | 8x47 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | H8 | N | 324 | 8x47 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM7 | V | 323 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL1 | V | 71 | 12x49 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL1 | V | 71 | 12x49 | G.H5 | E | 370 | G.H5.22 |
Polar | TM6 | Y | 256 | 6x25 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | Y | 256 | 6x25 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | A | 257 | 6x26 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | N | 505 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | N | 505 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | N | 505 | - | G.S2 | I | 192 | G.S2.01 |
Polar | TM6 | R | 260 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM6 | R | 260 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | R | 260 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM3 | R | 142 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | E | 459 | - | G.HN | L | 32 | G.HN.47 |
Van-der-waals | C-term | E | 459 | - | G.HN | L | 32 | G.HN.47 |
Polar | TM3 | S | 145 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | S | 145 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | S | 145 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | K | 506 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | ICL2 | L | 150 | - | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | ICL3 | Q | 249 | - | G.S6 | Y | 343 | G.S6.05 |
Hydrophobic | C-term | V | 513 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | V | 513 | - | G.h1ha | G | 67 | G.h1ha.01 |
Polar | H8 | K | 325 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | K | 325 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | K | 325 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | S | 508 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | S | 508 | - | G.S2 | Y | 195 | G.S2.04 |
Polar | C-term | F | 510 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | F | 510 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | ICL2 | P | 149 | - | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 149 | - | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | ICL2 | L | 150 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 150 | - | G.H5 | F | 356 | G.H5.08 |
Ionic | TM4 | D | 156 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Polar | TM4 | D | 156 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | D | 156 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM6 | R | 260 | 6x29 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL1 | F | 72 | 12x50 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL1 | F | 72 | 12x50 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | C-term | E | 467 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | C-term | E | 467 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | C-term | E | 459 | - | G.HN | I | 28 | G.HN.43 |
Van-der-waals | C-term | E | 459 | - | G.HN | I | 28 | G.HN.43 |
Polar | C-term | S | 508 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | S | 508 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM6 | E | 261 | 6x30 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM6 | E | 261 | 6x30 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | F | 373 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | F | 373 | - | G.H2 | I | 220 | G.H2.08 |
Aromatic | C-term | F | 373 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | F | 373 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | F | 373 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | H8 | K | 325 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | F | 373 | - | G.H3 | L | 264 | G.H3.15 |
Polar | C-term | F | 455 | - | G.HN | Q | 35 | G.HN.50 |
Hydrophobic | C-term | P | 511 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | P | 511 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | ICL1 | K | 73 | 12x51 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL1 | K | 73 | 12x51 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | I | 380 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | I | 380 | - | G.H3 | T | 260 | G.H3.11 |
Polar | TM2 | T | 76 | 2x39 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | M | 501 | - | G.H2 | K | 218 | G.H2.06 |
Van-der-waals | C-term | M | 501 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | TM3 | R | 142 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | E | 484 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | E | 484 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | E | 484 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | S | 466 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | C-term | S | 466 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | C-term | P | 461 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Van-der-waals | C-term | P | 461 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Hydrophobic | TM6 | A | 257 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | A | 257 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | H8 | V | 327 | 8x50 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | S | 508 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | TM6 | I | 254 | 6x23 | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | TM6 | I | 254 | 6x23 | G.S6 | F | 340 | G.S6.02 |
Polar | ICL2 | L | 150 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | L | 150 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | I | 254 | 6x23 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | I | 254 | 6x23 | G.h4s6 | R | 338 | G.h4s6.20 |
Ionic | ICL1 | K | 73 | 12x51 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL1 | K | 73 | 12x51 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL1 | K | 73 | 12x51 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | C-term | F | 510 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | F | 510 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | TM6 | L | 264 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | L | 264 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | E | 263 | 6x32 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | E | 263 | 6x32 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | N | 324 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | N | 324 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | N | 324 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | L | 150 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 150 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | I | 487 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | I | 487 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | K | 512 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | TM6 | T | 267 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | I | 509 | - | G.S2 | C | 196 | G.S2.05 |
Polar | TM2 | S | 74 | 2x37 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM6 | R | 260 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 260 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM7 | V | 323 | 7x56 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM7 | V | 323 | 7x56 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | V | 146 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | F | 373 | - | G.H3 | P | 265 | G.H3.16 |
Polar | C-term | Q | 488 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | Q | 488 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | Q | 488 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | L | 369 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | ICL2 | L | 150 | - | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM6 | E | 261 | 6x30 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | K | 506 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | K | 506 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | K | 506 | - | G.S2 | N | 193 | G.S2.02 |
Polar | TM6 | R | 260 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | R | 260 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | R | 260 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | L | 369 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | ICL1 | F | 72 | 12x50 | G.H5 | I | 371 | G.H5.23 |