Gt2 - GPR183 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 A 242 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 242 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 242 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 137 34x51 G.H5 I 343 G.H5.15
Polar TM5 T 226 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 T 226 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 T 226 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 N 230 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 N 230 5x72 G.S6 Y 320 G.S6.02
Hydrophobic ICL3 L 232 - G.H4 L 308 G.H4.16
Hydrophobic TM6 V 238 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 V 238 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 246 6x37 G.H5 L 353 G.H5.25
Polar TM7 A 311 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 A 311 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 A 311 7x56 G.H5 G 352 G.H5.24
Polar TM2 T 66 2x39 G.H5 D 350 G.H5.22
Polar TM2 N 64 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 64 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL3 T 233 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 T 233 - G.h4s6 E 318 G.h4s6.12
Ionic ICL2 K 141 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 141 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 141 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 141 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 L 223 5x65 G.H5 I 344 G.H5.16
Ionic H8 K 313 8x48 G.H5 E 346 G.H5.18
Hydrophobic ICL2 L 137 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 137 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM3 V 133 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 133 3x54 G.H5 L 348 G.H5.20
Polar TM2 T 66 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 66 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 66 2x39 G.H5 C 351 G.H5.23
Ionic TM4 R 144 4x38 G.HN D 28 G.HN.52
Polar TM4 R 144 4x38 G.HN D 28 G.HN.52
Hydrophobic TM4 R 144 4x38 G.HN D 28 G.HN.52
Van-der-waals TM4 R 144 4x38 G.HN D 28 G.HN.52
Ionic H8 K 313 8x48 G.H5 D 350 G.H5.22
Polar H8 K 313 8x48 G.H5 D 350 G.H5.22
Hydrophobic H8 K 313 8x48 G.H5 D 350 G.H5.22
Van-der-waals H8 K 313 8x48 G.H5 D 350 G.H5.22
Van-der-waals TM6 K 241 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL3 T 233 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 223 5x65 G.H5 L 348 G.H5.20
Polar TM3 R 129 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 129 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 129 3x50 G.H5 C 351 G.H5.23
Polar TM3 A 132 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 132 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 132 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 242 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL3 T 233 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 137 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 137 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 136 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 K 141 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 K 141 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 Y 139 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 136 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 137 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 137 34x51 G.s2s3 K 192 G.s2s3.01
Polar ICL2 Y 139 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 139 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 238 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 T 245 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM7 A 311 7x56 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 132 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 132 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 V 238 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM5 K 222 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 222 5x64 G.H5 I 344 G.H5.16
Polar ICL2 N 140 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 N 140 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 T 233 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 T 233 - G.H5 K 345 G.H5.17
Ionic ICL2 K 143 34x57 G.H5 D 350 G.H5.22
Polar ICL2 K 143 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 K 143 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 232 - G.S6 Y 320 G.S6.02
Polar TM5 N 230 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 N 230 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 I 249 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 133 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 K 313 8x48 G.H5 K 349 G.H5.21
Polar ICL3 S 236 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 S 236 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 S 236 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 232 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 L 232 - G.S6 I 319 G.S6.01
Hydrophobic ICL2 P 136 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 136 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM7 F 310 7x55 G.H5 G 352 G.H5.24
Van-der-waals TM7 F 310 7x55 G.H5 G 352 G.H5.24
Hydrophobic TM3 R 129 3x50 G.H5 L 353 G.H5.25