G12 - GPBA receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 T 191 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM5 V 206 5x79 G.H4 V 332 G.H4.12
Van-der-waals TM5 V 206 5x79 G.H4 V 332 G.H4.12
Hydrophobic ICL2 P 117 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 117 - G.H5 K 367 G.H5.12
Ionic H8 R 286 8x49 G.H5 D 377 G.H5.22
Polar H8 R 286 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 R 286 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 R 286 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM3 R 110 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 L 214 6x25 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 L 214 6x25 G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 L 118 - G.H5 K 367 G.H5.12
Hydrophobic TM5 L 202 5x75 G.S6 L 346 G.S6.01
Van-der-waals TM5 L 202 5x75 G.S6 L 346 G.S6.01
Hydrophobic H8 D 284 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 284 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 Q 285 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 Q 285 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 L 202 5x75 G.S6 F 347 G.S6.02
Hydrophobic TM6 L 214 6x25 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 L 214 6x25 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM7 G 283 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 G 283 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 118 - G.H5 V 366 G.H5.11
Polar TM5 V 206 5x79 G.H4 Q 333 G.H4.13
Hydrophobic TM5 V 206 5x79 G.H4 Q 333 G.H4.13
Van-der-waals TM5 V 206 5x79 G.H4 Q 333 G.H4.13
Hydrophobic TM5 V 206 5x79 G.S6 H 348 G.S6.03
Van-der-waals TM5 V 206 5x79 G.S6 H 348 G.S6.03
Hydrophobic TM5 V 206 5x79 G.H4 R 329 G.H4.09
Van-der-waals TM5 V 206 5x79 G.H4 R 329 G.H4.09
Hydrophobic TM6 L 214 6x25 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 L 214 6x25 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM3 V 114 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 114 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM6 Q 222 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 118 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 118 - G.H5 I 370 G.H5.15
Polar TM5 A 205 5x78 G.H4 R 329 G.H4.09
Hydrophobic TM5 A 205 5x78 G.H4 R 329 G.H4.09
Van-der-waals TM5 A 205 5x78 G.H4 R 329 G.H4.09
Hydrophobic TM3 A 113 3x53 G.H5 I 378 G.H5.23
Polar TM3 A 113 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 113 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 A 192 5x65 G.H5 M 379 G.H5.24
Van-der-waals TM5 A 192 5x65 G.H5 M 379 G.H5.24
Polar TM6 R 221 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 221 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 221 6x32 G.H5 M 379 G.H5.24
Ionic ICL3 R 208 - G.H4 D 326 G.H4.06
Hydrophobic ICL2 L 118 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 118 - G.S3 I 221 G.S3.01
Polar TM5 Q 195 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 195 5x68 G.H5 D 368 G.H5.13
Polar TM5 Q 195 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 Q 195 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 I 199 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 199 5x72 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 118 - G.S1 V 58 G.S1.02
Hydrophobic TM5 Q 195 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 Q 195 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 A 225 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 114 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM5 A 192 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 192 5x65 G.H5 L 375 G.H5.20
Polar TM6 R 221 6x32 G.H5 L 375 G.H5.20
Polar TM6 R 221 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 221 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 221 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 118 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 118 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 P 117 - G.H5 L 371 G.H5.16
Hydrophobic ICL3 R 208 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 R 208 - G.H4 R 329 G.H4.09
Hydrophobic TM5 I 199 5x72 G.h4s6 P 345 G.h4s6.20
Polar TM6 R 221 6x32 G.H5 K 376 G.H5.21
Hydrophobic TM6 R 221 6x32 G.H5 K 376 G.H5.21
Van-der-waals TM6 R 221 6x32 G.H5 K 376 G.H5.21
Hydrophobic TM5 L 202 5x75 G.S6 H 348 G.S6.03
Van-der-waals TM5 L 202 5x75 G.S6 H 348 G.S6.03
Hydrophobic TM5 V 188 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 117 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 117 - G.H5 I 370 G.H5.15
Hydrophobic TM3 V 114 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 114 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 120 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 120 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 Q 195 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 Q 195 5x68 G.H5 L 375 G.H5.20