G12 - GPRC6 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 684 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 I 684 3x54 G.H5 M 379 G.H5.24
Ionic TM5 E 776 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 776 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM5 E 776 5x64 G.H5 K 367 G.H5.12
Hydrophobic H8 L 850 8x55 G.H5 Q 372 G.H5.17
Van-der-waals H8 L 850 8x55 G.H5 Q 372 G.H5.17
Hydrophobic C-term V 861 - G.H5 H 364 G.H5.09
Van-der-waals C-term V 861 - G.H5 H 364 G.H5.09
Hydrophobic ICL2 F 690 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 690 - G.H5 K 367 G.H5.12
Hydrophobic C-term I 864 - G.s2s3 K 219 G.s2s3.01
Van-der-waals C-term I 864 - G.s2s3 K 219 G.s2s3.01
Polar C-term Y 854 - G.H5 D 368 G.H5.13
Hydrophobic C-term Y 854 - G.H5 D 368 G.H5.13
Van-der-waals C-term Y 854 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 P 692 - G.S3 I 221 G.S3.01
Hydrophobic TM3 F 688 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 F 688 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM3 A 687 3x57 G.H5 M 379 G.H5.24
Hydrophobic C-term A 865 - G.H5 R 360 G.H5.05
Van-der-waals C-term A 865 - G.H5 R 360 G.H5.05
Hydrophobic TM3 F 688 3x58 G.H5 L 375 G.H5.20
Polar C-term S 857 - G.H5 H 364 G.H5.09
Hydrophobic C-term S 857 - G.H5 H 364 G.H5.09
Van-der-waals C-term S 857 - G.H5 H 364 G.H5.09
Polar ICL1 S 626 12x52 G.H5 M 379 G.H5.24
Hydrophobic ICL1 S 626 12x52 G.H5 M 379 G.H5.24
Van-der-waals ICL1 S 626 12x52 G.H5 M 379 G.H5.24
Hydrophobic TM3 A 687 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM3 A 687 3x57 G.H5 L 371 G.H5.16
Hydrophobic H8 K 846 8x51 G.H5 L 380 G.H5.25
Hydrophobic ICL1 K 625 12x51 G.H5 L 380 G.H5.25
Polar C-term V 861 - G.H5 R 360 G.H5.05
Hydrophobic C-term V 861 - G.H5 R 360 G.H5.05
Van-der-waals C-term V 861 - G.H5 R 360 G.H5.05
Hydrophobic ICL2 F 690 - G.H5 I 370 G.H5.15
Polar C-term S 862 - G.H5 R 360 G.H5.05
Hydrophobic C-term S 862 - G.H5 R 360 G.H5.05
Van-der-waals C-term S 862 - G.H5 R 360 G.H5.05
Hydrophobic C-term F 903 - G.h4s6 P 345 G.h4s6.20
Polar C-term S 857 - G.H5 D 368 G.H5.13
Hydrophobic C-term S 857 - G.H5 D 368 G.H5.13
Van-der-waals C-term S 857 - G.H5 D 368 G.H5.13
Polar ICL2 P 692 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 692 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 692 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 692 - G.S3 P 222 G.S3.02
Polar TM3 K 683 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM3 K 683 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 683 3x53 G.H5 I 378 G.H5.23
Hydrophobic H8 F 849 8x54 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 690 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 K 696 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 696 - G.hns1 R 56 G.hns1.03
Polar C-term S 860 - G.H5 K 367 G.H5.12
Van-der-waals C-term S 860 - G.H5 K 367 G.H5.12
Ionic C-term K 894 - G.H4 E 325 G.H4.05
Polar C-term K 894 - G.H4 E 325 G.H4.05
Van-der-waals C-term K 894 - G.H4 E 325 G.H4.05
Hydrophobic H8 F 849 8x54 G.H5 L 375 G.H5.20
Hydrophobic C-term M 874 - H.HF K 198 H.HF.01
Polar C-term H 859 - G.H5 H 364 G.H5.09
Hydrophobic C-term W 892 - G.H5 F 361 G.H5.06
Hydrophobic C-term I 853 - G.H5 L 371 G.H5.16
Van-der-waals C-term I 853 - G.H5 L 371 G.H5.16
Polar TM3 A 687 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 687 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 687 3x57 G.H5 N 374 G.H5.19
Polar TM3 K 683 3x53 G.H5 M 379 G.H5.24
Hydrophobic TM3 K 683 3x53 G.H5 M 379 G.H5.24
Hydrophobic ICL3 Y 778 - G.H5 M 379 G.H5.24
Van-der-waals ICL3 Y 778 - G.H5 M 379 G.H5.24
Hydrophobic H8 K 846 8x51 G.H5 K 376 G.H5.21
Van-der-waals H8 K 846 8x51 G.H5 K 376 G.H5.21
Hydrophobic C-term I 853 - G.H5 L 375 G.H5.20
Van-der-waals C-term I 853 - G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 690 - G.S3 I 221 G.S3.01
Polar C-term S 858 - G.H5 H 364 G.H5.09
Hydrophobic C-term S 858 - G.H5 H 364 G.H5.09
Van-der-waals C-term S 858 - G.H5 H 364 G.H5.09
Aromatic C-term Y 854 - G.S6 F 347 G.S6.02
Hydrophobic C-term Y 854 - G.S6 F 347 G.S6.02
Van-der-waals C-term Y 854 - G.S6 F 347 G.S6.02
Polar ICL2 K 693 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 693 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 693 - G.hns1 R 56 G.hns1.03
Polar C-term Q 899 - G.S6 H 348 G.S6.03
Hydrophobic C-term Q 899 - G.S6 H 348 G.S6.03
Van-der-waals C-term Q 899 - G.S6 H 348 G.S6.03
Hydrophobic C-term S 857 - G.H5 L 371 G.H5.16
Hydrophobic TM3 L 686 3x56 G.H5 I 378 G.H5.23
Polar ICL2 Q 695 - G.H5 N 374 G.H5.19
Van-der-waals C-term S 863 - G.H5 R 360 G.H5.05
Hydrophobic ICL1 K 625 12x51 G.H5 M 379 G.H5.24
Van-der-waals ICL1 K 625 12x51 G.H5 M 379 G.H5.24
Hydrophobic C-term L 898 - G.H4 R 329 G.H4.09
Van-der-waals C-term L 898 - G.H4 R 329 G.H4.09
Hydrophobic TM3 A 687 3x57 G.H5 L 375 G.H5.20
Hydrophobic ICL1 P 622 12x48 G.H5 L 380 G.H5.25
Van-der-waals ICL1 P 622 12x48 G.H5 L 380 G.H5.25