G13 -
GPRC6 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | H8 | L | 850 | 8x55 | G.H5 | K | 372 | G.H5.21 |
Polar | ICL2 | K | 693 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | K | 693 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | K | 693 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL2 | D | 691 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | D | 691 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | D | 691 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | K | 693 | - | G.HN | E | 41 | G.HN.50 |
Van-der-waals | ICL2 | K | 693 | - | G.HN | E | 41 | G.HN.50 |
Hydrophobic | ICL2 | P | 692 | - | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ICL2 | P | 692 | - | G.HN | Y | 44 | G.HN.53 |
Hydrophobic | TM3 | F | 688 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | F | 688 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | F | 690 | - | G.S3 | P | 217 | G.S3.02 |
Hydrophobic | ICL2 | P | 692 | - | G.S3 | P | 217 | G.S3.02 |
Van-der-waals | ICL2 | P | 692 | - | G.S3 | P | 217 | G.S3.02 |
Hydrophobic | TM3 | L | 686 | 3x56 | G.H5 | L | 374 | G.H5.23 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | K | 699 | - | G.H5 | L | 374 | G.H5.23 |
Polar | ICL2 | P | 692 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | P | 692 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | P | 692 | - | G.HN | T | 43 | G.HN.52 |
Polar | ICL2 | K | 693 | - | G.HN | Y | 44 | G.HN.53 |
Hydrophobic | ICL2 | K | 693 | - | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ICL2 | K | 693 | - | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ICL1 | K | 625 | 12x51 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | S | 857 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | L | 694 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | L | 694 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | I | 864 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | C-term | I | 864 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL1 | S | 626 | 12x52 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | P | 692 | - | G.S1 | L | 48 | G.S1.01 |
Van-der-waals | ICL2 | P | 692 | - | G.S1 | L | 48 | G.S1.01 |
Polar | ICL2 | L | 694 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL1 | P | 622 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | P | 622 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | V | 861 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | C-term | V | 861 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ICL2 | S | 689 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | S | 689 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | S | 689 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 695 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 695 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | V | 861 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | P | 692 | - | G.hns1 | V | 45 | G.hns1.01 |
Van-der-waals | ICL2 | P | 692 | - | G.hns1 | V | 45 | G.hns1.01 |
Ionic | TM5 | E | 776 | 5x64 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | F | 690 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | F | 690 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | F | 690 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | F | 690 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | H8 | L | 850 | 8x55 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | I | 853 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | C-term | I | 853 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | I | 853 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL1 | K | 625 | 12x51 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | K | 846 | 8x51 | G.H5 | K | 372 | G.H5.21 |
Polar | H8 | L | 850 | 8x55 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | H8 | L | 850 | 8x55 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | H8 | L | 850 | 8x55 | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | Y | 854 | - | G.H5 | R | 360 | G.H5.09 |
Polar | ICL2 | P | 692 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | P | 692 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | P | 692 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | F | 697 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | D | 691 | - | G.S3 | P | 217 | G.S3.02 |
Polar | ICL2 | K | 696 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | K | 696 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | K | 696 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | D | 691 | - | G.HN | Y | 44 | G.HN.53 |
Hydrophobic | ICL2 | D | 691 | - | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ICL2 | D | 691 | - | G.HN | Y | 44 | G.HN.53 |
Polar | ICL1 | S | 626 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL1 | S | 626 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL1 | S | 626 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | K | 693 | - | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ICL2 | K | 693 | - | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL2 | Q | 695 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | D | 691 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | D | 691 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | Q | 695 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 695 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | I | 684 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | P | 692 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | P | 692 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | P | 692 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | L | 694 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | L | 694 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | L | 694 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL3 | Y | 778 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL3 | Y | 778 | - | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | K | 693 | - | G.HN | R | 40 | G.HN.49 |
Hydrophobic | ICL2 | K | 693 | - | G.HN | R | 40 | G.HN.49 |
Van-der-waals | ICL2 | K | 693 | - | G.HN | R | 40 | G.HN.49 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | K | 693 | - | G.hns1 | V | 45 | G.hns1.01 |
Van-der-waals | ICL2 | K | 693 | - | G.hns1 | V | 45 | G.hns1.01 |
Polar | C-term | Y | 854 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | C-term | Y | 854 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | C-term | Y | 854 | - | G.H5 | D | 364 | G.H5.13 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | K | 693 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | K | 693 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | K | 693 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | M | 375 | G.H5.24 |