Gq -
GPRC6 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | H8 | L | 850 | 8x55 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | H8 | L | 850 | 8x55 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | C-term | S | 857 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | I | 906 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | I | 906 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | P | 868 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | C-term | V | 861 | - | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | C-term | V | 861 | - | G.H5 | F | 341 | G.H5.08 |
Polar | ICL1 | K | 625 | 12x51 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL1 | K | 625 | 12x51 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL1 | K | 625 | 12x51 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | I | 853 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | C-term | I | 853 | - | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | I | 853 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM3 | L | 686 | 3x56 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | L | 686 | 3x56 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL2 | K | 699 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | K | 699 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | K | 699 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL2 | K | 696 | - | G.HN | R | 34 | G.HN.52 |
Hydrophobic | C-term | Y | 854 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | C-term | Y | 854 | - | G.S6 | Y | 325 | G.S6.02 |
Polar | C-term | S | 857 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | C-term | S | 857 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | C-term | S | 858 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | C-term | V | 861 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | L | 866 | - | G.S2 | L | 196 | G.S2.08 |
Van-der-waals | C-term | L | 866 | - | G.S2 | L | 196 | G.S2.08 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | I | 853 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | C-term | I | 853 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | M | 874 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | M | 874 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | ICL2 | P | 692 | - | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | P | 692 | - | G.hns1 | R | 38 | G.hns1.03 |
Ionic | ICL2 | D | 691 | - | G.hns1 | R | 38 | G.hns1.03 |
Polar | ICL2 | D | 691 | - | G.hns1 | R | 38 | G.hns1.03 |
Ionic | ICL2 | K | 699 | - | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | K | 699 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | K | 699 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | K | 699 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | V | 861 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | C-term | V | 861 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | C-term | L | 866 | - | G.H5 | I | 337 | G.H5.04 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | F | 849 | 8x54 | G.H5 | V | 359 | G.H5.26 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | K | 683 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | L | 871 | - | G.h1ha | G | 64 | G.h1ha.01 |
Van-der-waals | C-term | L | 871 | - | G.h1ha | G | 64 | G.h1ha.01 |
Hydrophobic | C-term | I | 853 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | C-term | I | 853 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | C-term | Y | 854 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL2 | K | 693 | - | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | K | 693 | - | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | P | 692 | - | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | ICL2 | F | 690 | - | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | C-term | L | 871 | - | G.H1 | R | 60 | G.H1.09 |
Van-der-waals | C-term | L | 871 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | TM3 | F | 688 | 3x58 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | Y | 856 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | C-term | Y | 856 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | P | 868 | - | G.h1ha | G | 64 | G.h1ha.01 |
Van-der-waals | C-term | P | 868 | - | G.h1ha | G | 64 | G.h1ha.01 |
Polar | ICL2 | Q | 695 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | Q | 695 | - | G.H5 | N | 352 | G.H5.19 |
Polar | C-term | P | 868 | - | G.h1ha | S | 65 | G.h1ha.02 |
Hydrophobic | H8 | L | 850 | 8x55 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM4 | Y | 702 | 4x30 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | M | 874 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | M | 874 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | C-term | I | 864 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | C-term | I | 864 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Polar | C-term | S | 857 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | S | 857 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | C-term | S | 857 | - | G.H5 | D | 346 | G.H5.13 |
Polar | TM3 | A | 687 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 687 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Polar | C-term | S | 867 | - | G.S2 | D | 195 | G.S2.07 |
Hydrophobic | C-term | L | 871 | - | G.S2 | F | 194 | G.S2.06 |
Van-der-waals | C-term | L | 871 | - | G.S2 | F | 194 | G.S2.06 |
Polar | TM3 | K | 683 | 3x53 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | I | 864 | - | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | C-term | I | 864 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | H8 | F | 849 | 8x54 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | Y | 854 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | Y | 854 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | C-term | Y | 854 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM3 | A | 687 | 3x57 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | S | 870 | - | G.S2 | P | 193 | G.S2.05 |
Hydrophobic | C-term | M | 874 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | TM2 | G | 628 | 2x34 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | I | 906 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | TM3 | K | 683 | 3x53 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | S | 860 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | S | 860 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | C-term | S | 860 | - | G.H5 | K | 345 | G.H5.12 |
Polar | ICL1 | S | 626 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL1 | S | 626 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL1 | S | 626 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | V | 861 | - | G.H5 | R | 338 | G.H5.05 |
Van-der-waals | C-term | V | 861 | - | G.H5 | R | 338 | G.H5.05 |
Hydrophobic | ICL1 | K | 625 | 12x51 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL1 | K | 625 | 12x51 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | D | 872 | - | G.h1ha | S | 65 | G.h1ha.02 |
Hydrophobic | C-term | D | 872 | - | G.h1ha | S | 65 | G.h1ha.02 |
Van-der-waals | C-term | D | 872 | - | G.h1ha | S | 65 | G.h1ha.02 |
Ionic | H8 | K | 846 | 8x51 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | H8 | K | 846 | 8x51 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | H8 | K | 846 | 8x51 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | H8 | K | 846 | 8x51 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM3 | F | 688 | 3x58 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | F | 688 | 3x58 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | I | 864 | - | G.S2 | L | 196 | G.S2.08 |
Hydrophobic | C-term | L | 866 | - | G.H1 | H | 63 | G.H1.12 |
Van-der-waals | C-term | L | 866 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | I | 348 | G.H5.15 |
Polar | C-term | S | 870 | - | G.S2 | D | 195 | G.S2.07 |
Hydrophobic | C-term | S | 870 | - | G.S2 | D | 195 | G.S2.07 |
Van-der-waals | C-term | S | 870 | - | G.S2 | D | 195 | G.S2.07 |