GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | P | 94 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Polar | TM6 | R | 253 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | R | 253 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | R | 253 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM3 | L | 159 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | L | 159 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM2 | P | 94 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Polar | ICL2 | R | 164 | 34x52 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 164 | 34x52 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM6 | M | 260 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | M | 260 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | L | 250 | 6x26 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | H8 | F | 331 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | S | 166 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | L | 167 | 34x55 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | L | 167 | 34x55 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Ionic | TM6 | R | 254 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Polar | TM6 | R | 254 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM6 | R | 254 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM6 | R | 254 | 6x30 | G.H5 | D | 364 | G.H5.13 |
Polar | ICL2 | R | 164 | 34x52 | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 164 | 34x52 | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | R | 169 | 34x57 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ICL2 | R | 169 | 34x57 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | A | 162 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.S3 | F | 218 | G.S3.03 |
Van-der-waals | ICL2 | M | 163 | 34x51 | G.S3 | F | 218 | G.S3.03 |
Polar | ICL2 | S | 166 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | S | 166 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | S | 166 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | M | 163 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM6 | R | 253 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Polar | ICL2 | C | 165 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | C | 165 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | C | 165 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM6 | K | 256 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | K | 256 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Polar | H8 | T | 330 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | T | 330 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | T | 330 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | G | 328 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | G | 328 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | TM3 | R | 155 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 155 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM2 | F | 98 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | F | 98 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Polar | H8 | E | 329 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | E | 329 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | E | 329 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 367 | G.H5.16 |
Polar | TM6 | R | 253 | 6x29 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM6 | R | 253 | 6x29 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 241 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | R | 253 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | R | 253 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL2 | L | 167 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | L | 167 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM5 | A | 244 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | A | 244 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM6 | R | 254 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Polar | H8 | E | 329 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | E | 329 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | E | 329 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | ICL2 | R | 164 | 34x52 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | TM3 | L | 159 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Polar | TM3 | A | 158 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 158 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM5 | V | 240 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Aromatic | ICL3 | H | 247 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | ICL3 | H | 247 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | ICL3 | H | 247 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM6 | R | 254 | 6x30 | G.H5 | L | 367 | G.H5.16 |
Ionic | ICL3 | H | 247 | - | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | TM3 | L | 159 | 3x54 | G.H5 | N | 370 | G.H5.19 |
Polar | H8 | T | 330 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | T | 330 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | T | 330 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | A | 257 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 257 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | M | 163 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | M | 163 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM6 | A | 257 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | A | 257 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | L | 250 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | L | 250 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | A | 162 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM3 | L | 159 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | L | 159 | 3x54 | G.H5 | L | 374 | G.H5.23 |