G15 - GPER complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 M 151 3x46 G.H5 L 374 G.H5.26
Van-der-waals TM3 M 151 3x46 G.H5 L 374 G.H5.26
Polar H8 G 328 8x47 G.H5 L 374 G.H5.26
Hydrophobic H8 G 328 8x47 G.H5 L 374 G.H5.26
Van-der-waals H8 G 328 8x47 G.H5 L 374 G.H5.26
Polar TM6 G 249 6x25 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 G 249 6x25 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 G 249 6x25 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 L 250 6x26 G.H5 A 365 G.H5.17
Hydrophobic TM3 L 159 3x54 G.H5 Y 367 G.H5.19
Hydrophobic TM5 A 244 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 A 244 5x68 G.H5 L 364 G.H5.16
Polar TM6 R 253 6x29 G.H5 N 372 G.H5.24
Van-der-waals TM6 R 253 6x29 G.H5 N 372 G.H5.24
Hydrophobic ICL2 M 163 34x51 G.H5 V 359 G.H5.11
Hydrophobic TM3 A 158 3x53 G.H5 I 371 G.H5.23
Ionic H8 E 340 8x59 G.h4s6 K 332 G.h4s6.14
Polar H8 E 340 8x59 G.h4s6 K 332 G.h4s6.14
Hydrophobic ICL2 M 163 34x51 G.S3 T 202 G.S3.01
Ionic ICL2 R 169 34x57 G.H5 E 370 G.H5.22
Polar ICL2 R 169 34x57 G.H5 E 370 G.H5.22
Hydrophobic ICL2 R 169 34x57 G.H5 E 370 G.H5.22
Van-der-waals ICL2 R 169 34x57 G.H5 E 370 G.H5.22
Hydrophobic TM6 M 260 6x36 G.H5 L 374 G.H5.26
Van-der-waals TM6 M 260 6x36 G.H5 L 374 G.H5.26
Polar ICL3 H 247 - G.H5 K 357 G.H5.09
Hydrophobic ICL3 H 247 - G.H5 K 357 G.H5.09
Van-der-waals ICL3 H 247 - G.H5 K 357 G.H5.09
Polar ICL2 S 166 34x54 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 S 166 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 S 166 34x54 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 M 163 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 M 163 34x51 G.H5 F 356 G.H5.08
Hydrophobic TM2 P 94 2x39 G.H5 E 370 G.H5.22
Van-der-waals TM2 P 94 2x39 G.H5 E 370 G.H5.22
Hydrophobic TM2 F 98 2x43 G.H5 L 373 G.H5.25
Van-der-waals TM2 F 98 2x43 G.H5 L 373 G.H5.25
Hydrophobic TM6 R 253 6x29 G.h4s6 S 336 G.h4s6.18
Van-der-waals TM6 R 253 6x29 G.h4s6 S 336 G.h4s6.18
Polar H8 G 328 8x47 G.H5 N 372 G.H5.24
Hydrophobic H8 G 328 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 G 328 8x47 G.H5 N 372 G.H5.24
Hydrophobic TM6 L 250 6x26 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 L 250 6x26 G.h4s6 R 338 G.h4s6.20
Polar ICL2 R 164 34x52 G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 R 164 34x52 G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 R 164 34x52 G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 L 167 34x55 G.HN K 37 G.HN.52
Hydrophobic ICL2 R 169 34x57 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 R 169 34x57 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 M 163 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 M 163 34x51 G.S1 L 43 G.S1.02
Hydrophobic TM3 R 155 3x50 G.H5 L 374 G.H5.26
Van-der-waals TM3 R 155 3x50 G.H5 L 374 G.H5.26
Hydrophobic TM7 L 327 7x56 G.H5 L 374 G.H5.26
Van-der-waals TM7 L 327 7x56 G.H5 L 374 G.H5.26
Ionic H8 E 329 8x48 G.h4s6 R 335 G.h4s6.17
Polar H8 E 329 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 E 329 8x48 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 E 329 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic ICL2 A 162 34x50 G.H5 L 364 G.H5.16
Hydrophobic TM2 T 92 2x37 G.H5 L 373 G.H5.25
Ionic TM6 R 253 6x29 G.H5 D 369 G.H5.21
Polar TM6 R 253 6x29 G.H5 D 369 G.H5.21
Hydrophobic TM6 R 253 6x29 G.H5 D 369 G.H5.21
Van-der-waals TM6 R 253 6x29 G.H5 D 369 G.H5.21
Hydrophobic H8 G 328 8x47 G.H5 L 373 G.H5.25
Van-der-waals H8 G 328 8x47 G.H5 L 373 G.H5.25
Hydrophobic H8 T 330 8x49 G.H5 L 373 G.H5.25
Van-der-waals H8 T 330 8x49 G.H5 L 373 G.H5.25
Hydrophobic TM3 R 155 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 L 159 3x54 G.H5 L 368 G.H5.20
Hydrophobic ICL2 C 165 34x53 G.H5 Y 367 G.H5.19
Polar ICL2 L 167 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 L 167 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic TM5 L 241 5x65 G.H5 L 368 G.H5.20
Van-der-waals TM5 L 241 5x65 G.H5 L 368 G.H5.20
Hydrophobic TM3 L 159 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 L 159 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM6 M 260 6x36 G.H5 N 372 G.H5.24
Van-der-waals TM6 M 260 6x36 G.H5 N 372 G.H5.24
Hydrophobic TM3 A 158 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 Y 367 G.H5.19
Polar ICL2 R 164 34x52 G.s2s3 Q 200 G.s2s3.01
Van-der-waals ICL2 R 164 34x52 G.s2s3 Q 200 G.s2s3.01
Hydrophobic ICL2 A 162 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 A 162 34x50 G.H5 V 363 G.H5.15
Polar ICL2 S 166 34x54 G.H5 Y 367 G.H5.19
Van-der-waals TM7 L 327 7x56 G.H5 N 372 G.H5.24
Polar H8 E 329 8x48 G.H5 N 372 G.H5.24
Van-der-waals H8 E 329 8x48 G.H5 N 372 G.H5.24
Polar ICL2 R 164 34x52 G.S3 T 202 G.S3.01
Polar TM6 R 253 6x29 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM6 R 253 6x29 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 R 253 6x29 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM7 Y 324 7x53 G.H5 L 374 G.H5.26
Van-der-waals TM7 Y 324 7x53 G.H5 L 374 G.H5.26
Polar TM6 A 257 6x33 G.H5 N 372 G.H5.24
Hydrophobic TM6 A 257 6x33 G.H5 N 372 G.H5.24
Van-der-waals TM6 A 257 6x33 G.H5 N 372 G.H5.24
Hydrophobic TM3 L 159 3x54 G.H5 I 371 G.H5.23
Van-der-waals TM3 L 159 3x54 G.H5 I 371 G.H5.23
Hydrophobic ICL2 M 163 34x51 G.H5 R 360 G.H5.12
Van-der-waals ICL2 M 163 34x51 G.H5 R 360 G.H5.12
Ionic ICL3 H 247 - G.H5 D 361 G.H5.13
Polar ICL3 H 247 - G.H5 D 361 G.H5.13
Hydrophobic ICL3 H 247 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 H 247 - G.H5 D 361 G.H5.13
Van-der-waals TM7 I 323 7x52 G.H5 L 374 G.H5.26
Hydrophobic ICL2 M 163 34x51 G.H5 V 363 G.H5.15
Hydrophobic TM6 L 250 6x26 G.H5 L 364 G.H5.16
Hydrophobic TM6 A 257 6x33 G.H5 L 368 G.H5.20
Van-der-waals TM6 A 257 6x33 G.H5 L 368 G.H5.20
Hydrophobic TM6 L 250 6x26 G.H5 L 368 G.H5.20
Polar ICL2 A 162 34x50 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 A 162 34x50 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 A 162 34x50 G.H5 Y 367 G.H5.19
Hydrophobic TM2 F 98 2x43 G.H5 L 374 G.H5.26
Van-der-waals TM2 F 98 2x43 G.H5 L 374 G.H5.26
Hydrophobic ICL2 L 167 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 L 167 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic TM4 T 170 4x38 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 T 170 4x38 G.hns1 R 40 G.hns1.02