Gi3 - GPER complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 H 173 4x41 G.HN R 24 G.HN.48
Hydrophobic TM2 P 94 2x39 G.H5 E 350 G.H5.22
Van-der-waals TM2 P 94 2x39 G.H5 E 350 G.H5.22
Ionic TM6 R 254 6x30 G.H5 D 341 G.H5.13
Polar TM6 R 254 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 254 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 254 6x30 G.H5 D 341 G.H5.13
Hydrophobic ICL2 M 163 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 M 163 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 A 244 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 M 163 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 163 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 M 163 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 M 163 34x51 G.H5 T 340 G.H5.12
Polar TM6 R 251 6x27 G.S6 Y 320 G.S6.02
Aromatic TM6 R 251 6x27 G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 251 6x27 G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 251 6x27 G.S6 Y 320 G.S6.02
Polar TM3 A 158 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 261 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 260 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 260 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 257 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 257 6x33 G.H5 L 348 G.H5.20
Ionic TM6 R 251 6x27 G.H5 D 341 G.H5.13
Polar TM6 R 251 6x27 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 251 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM5 L 241 5x65 G.H5 I 344 G.H5.16
Ionic TM6 R 251 6x27 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 251 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 251 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 251 6x27 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 253 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 253 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 253 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 M 260 6x36 G.H5 Y 354 G.H5.26
Van-der-waals TM6 M 260 6x36 G.H5 Y 354 G.H5.26
Polar TM6 R 248 6x24 G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 248 6x24 G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 248 6x24 G.S6 Y 320 G.S6.02
Van-der-waals TM6 A 257 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 155 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 155 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM2 P 94 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 167 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 167 34x55 G.hns1 K 32 G.hns1.03
Ionic ICL2 R 169 34x57 G.H5 E 350 G.H5.22
Polar ICL2 R 169 34x57 G.H5 E 350 G.H5.22
Polar TM6 R 248 6x24 G.S6 H 322 G.S6.04
Hydrophobic TM6 R 248 6x24 G.S6 H 322 G.S6.04
Van-der-waals TM6 R 248 6x24 G.S6 H 322 G.S6.04
Polar ICL2 S 166 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 S 166 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 166 34x54 G.hns1 A 31 G.hns1.02
Polar TM6 K 256 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 256 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 256 6x32 G.H5 Y 354 G.H5.26
Polar H8 T 330 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 T 330 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 T 330 8x49 G.H5 K 349 G.H5.21
Polar TM6 R 251 6x27 G.S6 I 319 G.S6.01
Hydrophobic ICL2 A 162 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 L 159 3x54 G.H5 I 344 G.H5.16
Polar TM6 R 248 6x24 G.S6 T 321 G.S6.03
Van-der-waals TM6 R 248 6x24 G.S6 T 321 G.S6.03
Van-der-waals ICL2 M 163 34x51 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 L 159 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 167 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 L 167 34x55 G.HN E 28 G.HN.52
Polar ICL2 R 169 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 169 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 169 34x57 G.H5 C 351 G.H5.23
Polar TM6 R 248 6x24 G.S6 I 319 G.S6.01
Van-der-waals TM6 R 248 6x24 G.S6 I 319 G.S6.01
Hydrophobic TM5 V 240 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 253 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 253 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM7 L 327 7x56 G.H5 Y 354 G.H5.26
Ionic ICL2 R 164 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 164 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 164 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 164 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 164 34x52 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 M 163 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 163 34x51 G.S3 L 194 G.S3.01
Polar TM6 R 253 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 253 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 253 6x29 G.h4s6 D 315 G.h4s6.09
Polar H8 G 328 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 328 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 328 8x47 G.H5 G 352 G.H5.24
Polar H8 E 329 8x48 G.H5 Y 354 G.H5.26
Hydrophobic H8 E 329 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 E 329 8x48 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 A 162 34x50 G.H5 I 343 G.H5.15
Polar TM6 R 253 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 R 253 6x29 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 R 253 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM3 L 159 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 159 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 L 241 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 158 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 158 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 159 3x54 G.H5 L 353 G.H5.25
Polar TM3 R 155 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 C 351 G.H5.23