Gs - GPR15 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 139 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 139 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL1 S 64 - G.H5 E 392 G.H5.24
Hydrophobic TM6 S 239 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 S 239 6x33 G.H5 L 394 G.H5.26
Polar TM2 R 66 2x37 G.H5 E 392 G.H5.24
Hydrophobic TM2 R 66 2x37 G.H5 E 392 G.H5.24
Van-der-waals TM2 R 66 2x37 G.H5 E 392 G.H5.24
Polar TM4 R 146 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 R 146 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 R 146 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM6 K 235 6x29 G.H5 R 389 G.H5.21
Van-der-waals TM6 K 235 6x29 G.H5 R 389 G.H5.21
Aromatic ICL2 R 142 34x54 G.S3 F 219 G.S3.03
Hydrophobic ICL2 R 142 34x54 G.S3 F 219 G.S3.03
Van-der-waals ICL2 R 142 34x54 G.S3 F 219 G.S3.03
Hydrophobic TM6 H 232 6x26 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 H 232 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 L 236 6x30 G.H5 L 394 G.H5.26
Polar ICL3 Y 226 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 Y 226 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 V 139 34x51 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 V 139 34x51 G.s2s3 D 215 G.s2s3.01
Polar ICL2 R 145 34x57 G.H5 L 393 G.H5.25
Hydrophobic ICL2 R 145 34x57 G.H5 L 393 G.H5.25
Hydrophobic TM2 L 67 2x38 G.H5 L 393 G.H5.25
Van-der-waals TM2 L 67 2x38 G.H5 L 393 G.H5.25
Polar ICL2 R 142 34x54 G.S1 H 41 G.S1.02
Aromatic ICL2 R 142 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 142 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 142 34x54 G.S1 H 41 G.S1.02
Polar TM6 K 235 6x29 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM6 K 235 6x29 G.h4s6 R 356 G.h4s6.12
Polar ICL2 R 142 34x54 G.S3 N 218 G.S3.02
Van-der-waals ICL2 R 142 34x54 G.S3 N 218 G.S3.02
Hydrophobic ICL2 R 145 34x57 G.H5 L 388 G.H5.20
Van-der-waals ICL2 R 145 34x57 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 222 5x65 G.H5 R 385 G.H5.17
Polar H8 Y 308 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 Y 308 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 Y 308 8x49 G.H5 E 392 G.H5.24
Polar ICL2 V 139 34x51 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 V 139 34x51 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 V 139 34x51 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 R 142 34x54 G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 142 34x54 G.S3 V 217 G.S3.01
Polar TM6 H 232 6x26 G.S6 C 359 G.S6.01
Hydrophobic TM6 H 232 6x26 G.S6 C 359 G.S6.01
Van-der-waals TM6 H 232 6x26 G.S6 C 359 G.S6.01
Ionic C-term D 334 - G.H3 R 280 G.H3.16
Polar C-term D 334 - G.H3 R 280 G.H3.16
Van-der-waals C-term D 334 - G.H3 R 280 G.H3.16
Hydrophobic ICL2 V 139 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 V 139 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL1 S 64 - G.H5 Y 391 G.H5.23
Van-der-waals ICL1 S 64 - G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 142 34x54 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 R 142 34x54 G.H5 Q 384 G.H5.16
Polar TM6 N 233 6x27 G.H5 R 385 G.H5.17
Van-der-waals TM6 N 233 6x27 G.H5 R 385 G.H5.17
Polar TM5 H 225 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 225 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 225 5x68 G.H5 R 385 G.H5.17
Polar TM4 D 148 4x40 G.HN Q 31 G.HN.48
Hydrophobic TM3 A 134 3x53 G.H5 L 388 G.H5.20
Hydrophobic TM2 I 68 2x39 G.H5 L 393 G.H5.25
Hydrophobic C-term L 337 - G.H3 R 280 G.H3.16
Polar TM4 D 148 4x40 G.HN Q 35 G.HN.52
Hydrophobic TM4 D 148 4x40 G.HN Q 35 G.HN.52
Van-der-waals TM4 D 148 4x40 G.HN Q 35 G.HN.52
Polar TM2 R 66 2x37 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 66 2x37 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 66 2x37 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 236 6x30 G.H5 R 385 G.H5.17
Polar TM6 K 235 6x29 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM6 K 235 6x29 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 K 235 6x29 G.h4s6 G 355 G.h4s6.11
Ionic TM5 K 221 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 221 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 221 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL2 P 138 34x50 G.H5 D 381 G.H5.13
Van-der-waals ICL2 P 138 34x50 G.H5 D 381 G.H5.13
Hydrophobic ICL2 K 143 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 K 143 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM2 R 66 2x37 G.H5 L 393 G.H5.25
Polar ICL2 R 142 34x54 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 R 142 34x54 G.hns1 A 39 G.hns1.03
Polar TM6 K 235 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 K 235 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 K 235 6x29 G.h4s6 Y 358 G.h4s6.20
Polar ICL2 P 138 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 138 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 138 34x50 G.H5 Q 384 G.H5.16
Polar ICL1 S 64 - G.hns1 R 38 G.hns1.02
Polar TM6 H 232 6x26 G.S6 Y 360 G.S6.02
Aromatic TM6 H 232 6x26 G.S6 Y 360 G.S6.02
Hydrophobic TM6 H 232 6x26 G.S6 Y 360 G.S6.02
Van-der-waals TM6 H 232 6x26 G.S6 Y 360 G.S6.02